Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ruth F. Deighton"'
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161828 (2016)
Although correlation network studies from co-expression analysis are increasingly popular, they are rarely applied to proteomics datasets. Protein co-expression analysis provides a complementary view of underlying trends, which can be overlooked by c
Externí odkaz:
https://doaj.org/article/5500bda8e0be4cc2b40ea75406c3c336
Publikováno v:
Caquineau, C, Ireland, K, Deighton, R, Wroe, A & Hughes, K 2017, ' Integrated Assessment and Feedback Practices and Effective Transition to Junior Honours ', vol. 5, no. 2 Sp. Iss, pp. 12-21 . https://doi.org/10.14297/jpaap.v5i2.286
This study focused on a newly implemented large science course whose main aim was to prepare students effectively for Junior Honours, and whose learning outcomes included the development of core competencies in scientific learning such as scientific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc5498e8f624851056638580659b48a
https://www.pure.ed.ac.uk/ws/files/41254295/Integrated_Assessment_and_Feedback_Practices_and_Effective_Transition_to_Junior_Honours.pdf
https://www.pure.ed.ac.uk/ws/files/41254295/Integrated_Assessment_and_Feedback_Practices_and_Effective_Transition_to_Junior_Honours.pdf
Publikováno v:
Kanonidis, E I, Roy, M M, Deighton, R F & Le Bihan, T 2016, ' Protein Co-Expression Analysis as a Strategy to Complement a Standard Quantitative Proteomics Approach : Case of a Glioblastoma Multiforme Study ', PLoS ONE, vol. 11, no. 8, pp. e0161828 . https://doi.org/10.1371/journal.pone.0161828
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161828 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161828 (2016)
Although correlation network studies from co-expression analysis are increasingly popular, they are rarely applied to proteomics datasets. Protein co-expression analysis provides a complementary view of underlying trends, which can be overlooked by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d50a956f8e1f6d8737b47b99d44f6d
https://www.pure.ed.ac.uk/ws/files/27676557/Deighton_R_Protein_co_expression....pdf
https://www.pure.ed.ac.uk/ws/files/27676557/Deighton_R_Protein_co_expression....pdf
Autor:
Sarah F. Martin, James L. Searcy, Catherine M. Gliddon, Ruth F. Deighton, Thierry Le Bihan, Lorraine E. Kerr, Rachel James, Joanne Povey, James McCulloch, Karen Horsburgh
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
James, R, Searcy, J L, Le Bihan, T, Martin, S F, Gliddon, C M, Povey, J, Deighton, R F, Kerr, L E, McCulloch, J & Horsburgh, K 2012, ' Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge ', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 1, pp. 164-176 . https://doi.org/10.1038/jcbfm.2011.120
James, R, Searcy, J L, Le Bihan, T, Martin, S F, Gliddon, C M, Povey, J, Deighton, R F, Kerr, L E, McCulloch, J & Horsburgh, K 2012, ' Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge ', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 1, pp. 164-176 . https://doi.org/10.1038/jcbfm.2011.120
Apolipoprotein E (APOE)-ɛ4 is associated with a deleterious outcome after ischemic brain injury, which may involve abnormal regulation of mitochondrial function. We have assessed the mitochondrial proteomic response of APOE-ɛ3 and APOE-ɛ4 transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f1f91da90dbecc16eb9bbe8186df6b
http://europepmc.org/articles/PMC3323298
http://europepmc.org/articles/PMC3323298
Publikováno v:
Molecular Neurobiology. 42:64-75
It has long been recognised that malignant tumours favour aerobic glycolysis to generate ATP and contain abnormalities of the intrinsic, mitochondria-dependent, apoptotic pathway, suggesting the involvement of dysfunctional mitochondria in tumour pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68a2151b109a5aab500679eb03e2cc8
https://doi.org/10.1007/s12035-010-8133-5
https://doi.org/10.1007/s12035-010-8133-5
Publikováno v:
Brain Pathology. 20:691-703
Proteomics is increasingly employed in both neurological and oncological research to provide insight into the molecular basis of disease but rarely has a coherent, novel pathophysiological insight emerged. Gliomas account for >50% of adult primary in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cfa542b9f373839f88d8bba9bcf453d
https://doi.org/10.1111/j.1750-3639.2010.00376.x
https://doi.org/10.1111/j.1750-3639.2010.00376.x
Autor:
Julia M. Edgar, Alice M. J. Gerth, Sarah F. Martin, Ian R. Whittle, Lorraine E. Kerr, Ruth F. Deighton, Thierry Le Bihan, James McCulloch, Mailis C. McCulloch
Publikováno v:
Journal of Neuro-Oncology
Deighton, R F, Le Bihan, T, Martin, S, Gerth, A M J, McCulloch, M, Edgar, J M, Kerr, L E, Whittle, I R & McCulloch, J 2014, ' Interactions among mitochondrial proteins altered in glioblastoma ', Journal of Neuro-Oncology, vol. 118, no. 2, pp. 247-256 . https://doi.org/10.1007/s11060-014-1430-5
Deighton, R F, Le Bihan, T, Martin, S, Gerth, A M J, McCulloch, M, Edgar, J M, Kerr, L E, Whittle, I R & McCulloch, J 2014, ' Interactions among mitochondrial proteins altered in glioblastoma ', Journal of Neuro-Oncology, vol. 118, no. 2, pp. 247-256 . https://doi.org/10.1007/s11060-014-1430-5
Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb59c2206368d98f50387a7505e55ca
https://eprints.gla.ac.uk/94834/1/94834.pdf
https://eprints.gla.ac.uk/94834/1/94834.pdf
Autor:
Bashayer Al-Mubarak, Paul J. Meakin, Karen F.S. Bell, Sudhir Chowdhry, Ruth F. Deighton, Nóra M. Márkus, Giles E. Hardingham, John D. Hayes, Sofia Papadia
Publikováno v:
Proceedings of the National Academy of Sciences. 111
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of antioxidant genes, and its activation in astrocytes confers noncell-autonomous neuroprotection. A recent interesting and provocative study published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add5fe56d2b9eee892c258beeb9e0d95
https://doi.org/10.1073/pnas.1402097111
https://doi.org/10.1073/pnas.1402097111
Autor:
Ruth F. Deighton, Thierry Le Bihan, Abigail G. Herrmann, James L. Searcy, Lorraine E. Kerr, James McCulloch, Mailis C. McCulloch
Publikováno v:
Herrmann, A, Deighton, R F, Le Bihan, T, McCulloch, M C, Searcy, J L, Kerr, L E & McCulloch, J 2013, ' Adaptive changes in the neuronal proteome: mitochondrial energy production, endoplasmic reticulum stress, and ribosomal dysfunction in the cellular response to metabolic stress ', Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 5, pp. 673-683 . https://doi.org/10.1038/jcbfm.2012.204
Journal of Cerebral Blood Flow & Metabolism
Journal of Cerebral Blood Flow & Metabolism
Impaired energy metabolism in neurons is integral to a range of neurodegenerative diseases, from Alzheimer's disease to stroke. To investigate the complex molecular changes underpinning cellular adaptation to metabolic stress, we have defined the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f460b6e802acd73d5d9f7e1b75ebc9
https://hdl.handle.net/20.500.11820/8efb6e59-3ea2-4e1d-8a54-aeba7efca7a9
https://hdl.handle.net/20.500.11820/8efb6e59-3ea2-4e1d-8a54-aeba7efca7a9
Publikováno v:
Herrmann, A, Searcy, J L, Bihan, T L, McCulloch, J & Deighton, R F 2013, ' Total variance should drive data handling strategies in third generation proteomic studies ', Proteomics, vol. 13, no. 22, pp. 3251–3255 . https://doi.org/10.1002/pmic.201300056
Quantitative proteomics is entering its "third generation" where intricate experimental designs aim to increase the spatial and temporal resolution of protein changes. This paper re-analyses multiple internally consistent proteomic datasets generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc45b9a900468d8f41157c32042c43d
https://pubmed.ncbi.nlm.nih.gov/24123801
https://pubmed.ncbi.nlm.nih.gov/24123801