Effects of BNT162b2 mRNA vaccine on COVID-19 infection and hospitalisation amongst older people: matched case control study for England

Autor: Thomas F. D. Mason, Matt Whitston, Jack Hodgson, Ruth E. Watkinson, Yiu-Shing Lau, Omnia Abdulrazeg, Matt Sutton

Publikováno v: BMC Medicine, Vol 19, Iss 1, Pp 1-9 (2021)

Abstract Background The BNT162b2 mRNA vaccine has been shown to be effective at preventing serious COVID-19 events in clinical trials. There is less evidence on effectiveness in real-world settings, especially for older people. Here, we aimed to esti

Externí odkaz: https://doaj.org/article/b243e620935643748a73cd9c8b1a3c3b

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

Autor: Benhur Lee, Robert M. Cox, Jose R. Marengo, Negar Makhsous, Mart Toots, Jeong-Joong Yoon, Richard K. Plemper, Mugunthan Govindarajan, Satoshi Ikegame, Alexander L. Greninger, Michael G. Natchus, Ruth E. Watkinson, Michelle J. Lin, Julien Sourimant, Zachary M. Sticher, Alexander A. Kolykhalov, Patricia A. Thibault

Publikováno v: Nature microbiology

Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52729f7232a684354bf11b7c3674a89
https://doi.org/10.1038/s41564-020-0752-7

Effects of BNT162b2 mRNA vaccine on Covid-19 infection and hospitalisation among older people: matched case control study for England

Autor: Yui-Shing Lau, Thomas Mason, Jack Hodgson, Matt Sutton, Ruth E. Watkinson, Matthew Whitston, Omnia Abdulrazeg

BackgroundThe BNT162b2 mRNA vaccine has been shown to be effective at preventing serious Covid-19 events in clinical trials. There is less evidence on effectiveness in real-world settings, especially for older people. The rapid roll-out of the NHS va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faf8d9f2a459a8eceac6a167527be506
https://doi.org/10.1101/2021.04.19.21255461

Ethnic inequalities in health-related quality of life among older adults in England: secondary analysis of a national cross-sectional survey

Autor: Alexander Turner, Ruth E. Watkinson, Matt Sutton

Publikováno v: Watkinson, R E, Sutton, M & Turner, A J 2021, ' Ethnic inequalities in health-related quality of life among older adults in England : secondary analysis of a national cross-sectional survey ', The Lancet Public Health, vol. 6, no. 3, pp. e145-e154 . https://doi.org/10.1016/S2468-2667(20)30287-5
The Lancet Public Health, Vol 6, Iss 3, Pp e145-e154 (2021)

Summary Background The population of older adults (ie, those aged ≥55 years) in England is becoming increasingly ethnically diverse. Previous reports indicate that ethnic inequalities in health exist among older adults, but information is limited b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b26aea74bee76b132e1bb72393c9642
https://pubmed.ncbi.nlm.nih.gov/33516279

TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity

Autor: Bjørn Dalhus, Algirdas Grevys, Jan Terje Andersen, Leo C. James, Inger Sandlie, Terje E. Michaelsen, Malin C. Bern, Lene Støkken Høydahl, Stian Foss, Martin Berner McAdam, Ruth E. Watkinson

Publikováno v: Journal of Immunology

Ab-coated viruses can be detected in the cytosol by the FcR tripartite motif-containing 21 (TRIM21), which rapidly recruits the proteasomal machinery and triggers induction of immune signaling. As such, TRIM21 plays a key role in intracellular protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9323bcad3d452e380e7b10d0b5e7da1e
https://doi.org/10.4049/jimmunol.1502601