Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ruth E. Pakyz"'
Autor:
Michiaki Kubo, Tobias Geisler, Dimitrios Alexopoulos, Gian Franco Gensini, Kiyuk Chang, Jean-Luc Reny, Joshua P. Lewis, Meinrad Gawaz, Elke Schaeffeler, Kevin P. Bliden, Stefan Winter, Eun Young Kim, Ruth E. Pakyz, Paul A. Gurbel, Rossella Marcucci, Israel Fernandez-Cadenas, Joan Montaner, Nadia Paarup Dridi, Li Gong, Jae-Gook Shin, Matthias Schwab, Ryan Whaley, Jurriën M. ten Berg, John H. Cleator, Pierre Fontana, Marco Valgimigli, Russ B. Altman, Ho-Sook Kim, Joshua D. Backman, Jolanta M. Siller-Matula, Daniel Aradi, Braxton D. Mitchell, Betti Giusti, Thomas O. Bergmeijer, Kathleen A. Ryan, Alan R. Shuldiner, Ming-Shien Wen, Jean-Pierre Déry, Marylyn D. Ritchie, Teri E. Klein, Dan M. Roden, Ming Ta Michael Lee, Dietmar Trenk, Gianluca Campo, Lene Holmvang, Willibald Hochholzer
Publikováno v:
Eur Heart J Cardiovasc Pharmacother
Aims Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual variability in on-treatment platelet inhibition (e.g. CYP2C19*2), evidence that these variants
Autor:
Linda Jeng, Rochelle N. Naylor, Haichen Zhang, Kristin A. Maloney, Miriam S. Udler, Tiinamaija Tuomi, Rinki Murphy, Ruth E. Pakyz, Toni I. Pollin, José P. Miranda, Louis H. Philipson, Jarno Kettunen, Fabrizio Barbetti, Janne Molnes, Siri Atma W. Greeley, Kevin Colclough, Uyenlinh L. Mirshahi, Sabrina Prudente
Publikováno v:
Diabetes. 69
Genetic testing for monogenic diabetes, essential for accurate diagnosis and appropriate treatment is underutilized. Obstacles include clinical overlap with type 1 and type 2 diabetes and difficulty distinguishing clinically significant (pathogenic/l
Autor:
Siri Atma W. Greeley, Courtney Thaxton, Haichen Zhang, Kristin A. Maloney, Toni I. Pollin, Rochelle N. Naylor, Megan A. Mayers, Kashyap A. Patel, Kevin Colclough, Miriam S. Udler, Ruth E. Pakyz
Publikováno v:
Diabetes. 69
Diagnosing and distinguishing monogenic diabetes, including some MODY (maturity-onset diabetes of the young), from type 1 or type 2 diabetes can have profound clinical implications: sulfonylureas vs. insulin or metformin for HNF1A- and HNF4A- diabete
Autor:
Jae-Gook Shin, Dan M. Roden, Stefan Winter, Paul A. Gurbel, Michiaki Kubo, Braxton D. Mitchell, Joshua P. Lewis, Yuki Bradford, Daniel Aradi, Kevin P. Bliden, Jurriën M. ten Berg, Thomas O. Bergmeijer, Kiyuk Chang, Ruth E. Pakyz, Alan R. Shuldiner, Ho-Sook Kim, Jean-Luc Reny, Meinrad Gawaz, Tobias Geisler, Gianluca Campo, Marco Valgimigli, Elke Schaeffeler, Jolanta M. Siller-Matula, Gian Franco Gensini, Lene Holmvang, Willibald Hochholzer, Rossella Marcucci, Betti Giusti, Ming Ta Michael Lee, Jean-Pierre Déry, Dietmar Trenk, Ming-Shien Wen, John M. Wallace, Marylyn D. Ritchie, Teri E. Klein, Israel Fernandez-Cadenas, Dimitrios Alexopoulos, Matthias Schwab, Ryan Whaley, John H. Cleator, Pierre Fontana, Joshua D. Backman, Russ B. Altman, Shefali S. Verma, Eun Young Kim, Nadia Paarup Dridi, Li Gong, Joan Montaner
Publikováno v:
Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics
Verma, S S, Bergmeijer, T O, Gong, L, Reny, J L, Lewis, J P, Mitchell, B D, Alexopoulos, D, Aradi, D, Altman, R B, Bliden, K, Bradford, Y, Campo, G, Chang, K, Cleator, J H, Déry, J P, Dridi, N P, Fernandez-Cadenas, I, Fontana, P, Gawaz, M, Geisler, T, Gensini, G F, Giusti, B, Gurbel, P A, Hochholzer, W, Holmvang, L, Kim, E Y, Kim, H S, Marcucci, R, Montaner, J, Backman, J D, Pakyz, R E, Roden, D M, Schaeffeler, E, Schwab, M, Shin, J G, Siller-Matula, J M, ten Berg, J M, Trenk, D, Valgimigli, M, Wallace, J, Wen, M S, Kubo, M, Lee, M T M, Whaley, R, Winter, S, Klein, T E, Shuldiner, A R, Ritchie, M D & for the ICPC Investigators 2020, ' Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel : A Study by the International Clopidogrel Pharmacogenomics Consortium ', Clinical Pharmacology and Therapeutics, vol. 108, no. 5, pp. 1067-1077 . https://doi.org/10.1002/cpt.1911
Clinical Pharmacology and Therapeutics, Vol. 108, No 5 (2020) pp. 1067-1077
Clinical Pharmacology and Therapeutics
Verma, S S, Bergmeijer, T O, Gong, L, Reny, J L, Lewis, J P, Mitchell, B D, Alexopoulos, D, Aradi, D, Altman, R B, Bliden, K, Bradford, Y, Campo, G, Chang, K, Cleator, J H, Déry, J P, Dridi, N P, Fernandez-Cadenas, I, Fontana, P, Gawaz, M, Geisler, T, Gensini, G F, Giusti, B, Gurbel, P A, Hochholzer, W, Holmvang, L, Kim, E Y, Kim, H S, Marcucci, R, Montaner, J, Backman, J D, Pakyz, R E, Roden, D M, Schaeffeler, E, Schwab, M, Shin, J G, Siller-Matula, J M, ten Berg, J M, Trenk, D, Valgimigli, M, Wallace, J, Wen, M S, Kubo, M, Lee, M T M, Whaley, R, Winter, S, Klein, T E, Shuldiner, A R, Ritchie, M D & for the ICPC Investigators 2020, ' Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel : A Study by the International Clopidogrel Pharmacogenomics Consortium ', Clinical Pharmacology and Therapeutics, vol. 108, no. 5, pp. 1067-1077 . https://doi.org/10.1002/cpt.1911
Clinical Pharmacology and Therapeutics, Vol. 108, No 5 (2020) pp. 1067-1077
Antiplatelet response to clopidogrel shows wide variation, and poor response is correlated with adverse clinical outcomes. CYP2C19 loss-of-function alleles play an important role in this response, but account for only a small proportion of variabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879ba4faf94686e3e39457e594e198cf
http://hdl.handle.net/11392/2437791
http://hdl.handle.net/11392/2437791
Autor:
Liewei Wang, Jill M. Pulley, Mark J. Ratain, Julie A. Johnson, Wolfgang Sadee, Rhonda M. Cooper-DeHoff, Teri E. Klein, Ruth E. Pakyz, Julie R. Field, Alan R. Shuldiner, Russ B. Altman, Mary V. Relling, Peter H. O'Donnell, Josh F. Peterson, Samuel K. Handelman, Peter J. Embi, Jasmine A. Luzum, Larisa H. Cavallari, Naveen L. Pereira, Cyrine E. Haidar, Kathleen Palmer, Michelle Whirl-Carrillo, Dan M. Roden, Kristin Weitzel, Robert R. Freimuth, Jonathan S. Schildcrout, Marc Beller, Amanda R. Elsey, Richard M. Weinshilboum
Publikováno v:
Clinical Pharmacology & Therapeutics. 102:502-510
Numerous pharmacogenetic clinical guidelines and recommendations have been published, but barriers have hindered the clinical implementation of pharmacogenetics. The Translational Pharmacogenetics Program (TPP) of the National Institutes of Health (N
Autor:
Issam Hamadeh, Devon C. Nwaba, Nita A. Limdi, Amer Ardati, Josh F. Peterson, James M. Stevenson, Russell A. Wilke, Craig R. Lee, Kristin Weitzel, Tameka D. Alestock, Yan Gong, Kathleen Palmer, Joshua C. Denny, Stephen E. Kimmel, Almut G. Winterstein, Richard B. Horenstein, Mark R. Vesely, Todd C. Skaar, Caitrin W. McDonough, Supatat Chumnumwat, Dyson T. Wake, James H. Willig, Petr Starostik, Larisa H. Cavallari, Linda J. B. Jeng, Karen E. Weck, Chrisly Dillon, Michael J. Clare-Salzler, D. Max Smith, Jorge A. Alsip, Vindhya B. Sriramoju, Rolf P. Kreutz, Chintan V. Dave, Julie A. Johnson, William B. Hillegass, Victoria M. Pratt, Toni I. Pollin, R. David Anderson, Rhonda M. Cooper-DeHoff, Richard Y. Zhao, Yee Ming Lee, Shawn W. Robinson, Brigitta C. Brott, Deepak Voora, Tomasz Stys, Lindsay J. Hines, Alan R. Shuldiner, Ruth E. Pakyz, Mark D. Kelemen, Alison H. Quinn, Edith A. Nutescu, Shuko Harada, Lawrence Brown, David R. Nelson, Oyunbileg Magvanjav, Philip E. Empey, Lucius A. Howell, Amanda R. Elsey, May E. Montasser, Nicholas Varunok, James C. Coons, Amber L. Beitelshees, George A. Stouffer, Julio D. Duarte, Jamie Schub
Objectives This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype–guided antiplatelet therapy after percutaneous coronary intervention (PCI). Background CYP2C19 loss-of-function alleles impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0020458ef2172864006eb4e8685cb22c
https://europepmc.org/articles/PMC5775044/
https://europepmc.org/articles/PMC5775044/
Autor:
Dan M. Roden, Marylyn D. Ritchie, Jae-Gook Shin, Braxton D. Mitchell, Teri E. Klein, Gian Franco Gensini, Jurriën M. ten Berg, Pierre Fontana, Lene Holmvang, Israel Fernandez-Cadenas, Willibald Hochholzer, Stefan Winter, Tabassome Simon, Ruth E. Pakyz, Paul A. Gurbel, Richard B. Horenstein, Ming-Shien Wen, Tobias Geisler, John H. Cleator, Marco Valgimigli, Ho-Sook Kim, Jean-Sébastien Hulot, Jolanta M. Siller-Matula, Dietmar Trenk, Gianluca Campo, Michiaki Kubo, Elke Schaeffeler, Nadia Paarup Dridi, Ming Ta Michael Lee, Li Gong, Joshua P. Lewis, Jean-Pierre Déry, Rossella Marcucci, Kiyuk Chang, Meinrad Gawaz, Kevin P. Bliden, Alan R. Shuldiner, Daniel Aradi, Thomas O. Bergmeijer, Betti Giusti, Russ B. Altman, Dimitrios Alexopoulos, Matthias Schwab, Ryan Whaley, Jean-Luc Reny, Joan Montaner, Eun Young Kim
Publikováno v:
American Heart Journal
American Heart Journal, Vol. 198 (2018) pp. 152-159
American Heart Journal, Elsevier, 2018, 198, pp.152-159. ⟨10.1016/j.ahj.2017.12.010⟩
American Heart Journal, Vol. 198 (2018) pp. 152-159
American Heart Journal, Elsevier, 2018, 198, pp.152-159. ⟨10.1016/j.ahj.2017.12.010⟩
RATIONALE: The P2Y(12) receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention or ischemic stroke. Platelet inhibition by clopidogrel shows wide inter-patient variability and high on-
Autor:
Nicholas P. Ambulos, Richard Y. Zhao, Mark R. Vesely, Courtney O'Neill, Tameka D. Alestock, Miriam G. Blitzer, Patrick F. McArdle, Toni I. Pollin, Richard B. Horenstein, Ruth E. Pakyz, Lawrence Brown, Shaun Bhatty, Amber L. Beitelshees, Alan R. Shuldiner, Linda J. B. Jeng, Kathleen Palmer, Jamie Schub, Mark D. Kelemen, Shawn W. Robinson, Casey Lynnette Overby, Kristin A. Maloney
Publikováno v:
American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 166:76-84
Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to a number of non-trivial practical barriers. We implemented a Personalized Anti-platelet Pharmacogenetics Program (PAP3) for cardiac
Autor:
Kenneth Rice, Amy J. Swift, Veronique Vitart, Lu Qi, Kaisa Silander, Olivier Le Bacquer, Laura Crisponi, David S. Siscovick, Bo Isomaa, Anne U. Jackson, Anke Tönjes, Richard N. Bergman, Rosa Maria Roccasecca, Luigi Ferrucci, Narisu Narisu, Kari Stefansson, Holly E. Syddall, Giuseppe Paolisso, Kim L. Ward, Paul Elliott, Scott M. Grundy, Paul Johnson, Jerome I. Rotter, Philippe Froguel, James B. Meigs, George Davey Smith, Andrew T. Hattersley, Leena Peltonen, Eric J.G. Sijbrands, Serena Sanna, María TeresaMartínez-Larrad, David Altshuler, Harald Grallert, Caroline S. Fox, Nita G. Forouhi, Dorret I. Boomsma, Harry Campbell, Jean Tichet, Angelo Scuteri, Aroon D. Hingorani, Daniel S. Pearson, Meena Kumari, Silvia Naitza, Shah Ebrahim, Manjinder S. Sandhu, Jose C. Florez, Cyrus Cooper, David M. Nathan, Joseph Hung, Fredrik Karpe, Ozren Polasek, Philip J. Barter, Ruth McPherson, Benjamin F. Voight, Wolfgang Rathmann, Abbas Dehghan, Udo Seedorf, Beverley M. Shields, Antti Jula, Pau Navarro, Josephine M. Egan, Rune R. Frants, Leif Groop, Gunnar Sigursson, Seppo Koskinen, Vincent Mooser, François Pattou, Jing Hua Zhao, Irene Pichler, John F. Peden, Göran Hallmans, Toshiko Tanaka, Ruth J. F. Loos, Peter Kovacs, Andrew D. Morris, Cécile Lecoeur, Jeffrey R. O'Connell, Massimo Mangino, Nicole Vogelzangs, Rhian Gwilliam, Gordon H. Williams, Carina Zabena, Naomi Hammond, Amélie Bonnefond, Björn Zethelius, Joachim Spranger, Nancy L. Pedersen, Christopher J. Groves, Nicholas J. Timpson, George Dedoussis, Veikko Salomaa, Peter Henneman, Andrew Walley, Serge Hercberg, Ian N. M. Day, Simon Heath, Matt Neville, Alex S. F. Doney, Robert Clarke, Olov Rolandsson, Panos Deloukas, Eric Boerwinkle, Y. AnteroKesaniemi, Mike Sampson, Gerard Waeber, Sven Bergmann, Ben A. Oostra, Manuel Serrano-Ríos, Mandy van Hoek, Christine Cavalcanti-Proença, Anna L. Gloyn, Ulla Sovio, Andrew P. Morris, Anneli Pouta, Amanda J. Bennett, Paul Scheet, Peter Schwarz, Jaakko Tuomilehto, Hugh Watkins, Johanna Kuusisto, Denis Rybin, Anna LiisaHartikainen, Maria GraziaFranzosi, Unnur Thorsteinsdottir, Rafn Benediktsson, Alan F. Wright, Colin N. Apalmer, Anuj Goel, Yavuz Ariyurek, Lars Lind, Robert Sladek, Stefan R. Bornstein, Reedik Mägi, Laila Simpson, Tim D. Spector, Paul W. Franks, Nicholas L. Smith, John R. B. Perry, Peter Vollenweider, Suzannah Bumpstead, Ruth E. Pakyz, Christa Meisinger, Alan R. Shuldiner, Josée Dupuis, Man Li, Eric J. Brunner, Francis S. Collins, Torben Hansen, James F. Wilson, Guangju Zhai, Igor Rudan, Nicole L. Glazer, Marco Orrù, Pierre Meneton, Knut Borch-Johnsen, Eleanor Wheeler, Gonçalo R. Abecasis, Mark I. McCarthy, Jouke JanHottenga, Inga Prokopenko, Ping An, Jérôme Delplanque, Albert Hofman, Andrew B. Singleton, Gabe Crawford, Thomas A. Buchanan, Avan Aihie Sayer, Richard M. Watanabe, David Schlessinger, A C Fedson, André G. Uitterlinden, Frank B. Hu, Jaqueline C. MWitteman, Dhiraj Varma, Ingrid B. Borecki, Sutapa Mukherjee, Murielle Bochud, Barbara Thorand, Christian Gieger, Lori L. Bonnycastle, Stephen J. Sharp, Markus Perola, Caroline Hayward, Kristin Ardlie, J. Graessler, Robert W. Mahley, Toby Johnson, Jian'an Luan, Joshua C. Randall, Cornelia M. van Duijn, Samuli Ripatti, Ko Willems van Dijk, Valgerdur Steinthorsdottir, Yurii S. Aulchenko, G. Mark Lathrop, Christian Dina, Eleftheria Zeggini, Cecilia M. Lindgren, Stavroula Kanoni, Timothy M. Frayling, Dawn M. Waterworth, Marika Kaakinen, Timo T. Valle, Diana Zelenika, Yii Der IdaChen, Angela Silveira, Nigel W. Rayner, Aimo Ruokonen, Yun Li, Cristian Pattaro, Annelli Sandbæk, Richa Saxena, Danielle Posthuma, Steven A. McCarroll, Niels Grarup, Samy Hadjadj, Pilar Galan, Xijing Han, Lyle J. Palmer, Ulf Gyllensten, Peter P. Pramstaller, Manuela Uda, Jarred B. McAteer, Brenda W.J.H. Penninx, Debbie A Lawlor, Torben Jørgensen, Beatrice Knight, Yvonne Böttcher, Claudia Langenberg, Nicole Soranzo, Ghislain Rocheleau, Erik Ingelsson, Mario A. Morken, Michael Roden, Felicity Payne, David R. Hillman, Michael Marmot, Karen L. Mohlke, Heather M. Stringham, Bruce M. Psaty, Gudmar Thorleifsson, Yoav Ben-Shlomo, Inês Barroso, W. H. Linda Kao, James S. Pankow, Valeriya Lyssenko, Nicholas J. Wareham, Tiinamaija Tuomi, Ann ChristineSyvänen, Braxton D. Mitchell, Alisa K. Manning, Mika Kivimäki, Peter Wagner, Praveen Sethupathy, G. BragiWalters, Jaakko Kaprio, Kijoung Song, Marjo Riitta-Järvelin, Michael A. Province, Andrew A. Hicks, Marilyn C. Cornelis, Sarah H. Wild, David Meyre, Guillaume Charpentier, Patrik K. E. Magnusson, David Melzer, Jennie Hui, Peter Shrader, Michael Stumvoll, Mark O. Goodarzi, Michael R. Erdos, Oluf Pedersen, Andreas Pfeiffer, Augustine Kong, Christian Herder, Laura J. Scott, John W. GYarnell, Kirsten Ohm Kyvik, Beverley Balkau, Antje Fischer-Rosinsky, Gonneke Willemsen, Thomas Illig, Neelam Hassanali, Markku Laakso, Michael Boehnke, John Beilby, Christopher S. Franklin, Fernando Rivadeneira, M. Carola Zillikens, Michael N. Weedon, Antonio Cao, Mark E. Cooper, Simon C. Potter, Eco J. C. de Geus, H.-Erich Wichmann, Amanda F. Elliott, Lachlan J. McOin, Sophie Visvikis-Siest, Thomas Sparsø, Laura J. McCulloch, Taina K. Lajunen, Peter S. Chines, Nabila Bouatia-Naji
Publikováno v:
Nature Genetics
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Hottenga, J J, de Geus, E J C, Kaprio, J, Kyvik, K O, Pedersen, N L, Perola, M, Posthuma, D, Rivadeneira, F, Uitterlinden, A G, Willems van Dijk, K, van Hoek, M, Vogelzangs, N, Willemsen, G, Witteman, J C M, Zillikens, M C, Penninx, B W J H, Boomsma, D I, van Duijn, C M, Aulchenko, Y S, Waterworth, D, Vollenweider, P, Peltonen, L, Mooser, V, Abecasis, G R, Wareham, N J, Sladek, R, Froguel, P, Watanabe, R M, Meigs, J B, Groop, L C, Boehnke, M, McCarthy, M I, Florez, J C & Barroso, I 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520
Nature genetics
U32
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Qi, L, Timpson, N J, Hayward, C, Vitart, V, Wild, S H, Morris, A, Rudan, I, Wright, A F & Campbell, H & Wilson, J F 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520
Nature Genetics, 42(2), 105-116. Nature Publishing Group
Yarnell, J 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ' Nature Genetics, vol. 42, no. 2, pp. 105-119 . DOI: 10.1038/ng.520
Nature Genetics; Vol 42
Nature Genetics, 42(2), 105-U32. Nature Publishing Group
Nature genetics, vol. 42, no. 2, pp. 105-116
Nature Genetics, 42(5), 464-464
Nature Genetics, 42(2), 105
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T H, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Lu, Q, Timpson, N J, Gieger, C, Zabena, C, Rocheleau, G, Ingelsson, E, An, P, O'Connell, J, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-16 . https://doi.org/10.1038/ng.520
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Hottenga, J J, de Geus, E J C, Kaprio, J, Kyvik, K O, Pedersen, N L, Perola, M, Posthuma, D, Rivadeneira, F, Uitterlinden, A G, Willems van Dijk, K, van Hoek, M, Vogelzangs, N, Willemsen, G, Witteman, J C M, Zillikens, M C, Penninx, B W J H, Boomsma, D I, van Duijn, C M, Aulchenko, Y S, Waterworth, D, Vollenweider, P, Peltonen, L, Mooser, V, Abecasis, G R, Wareham, N J, Sladek, R, Froguel, P, Watanabe, R M, Meigs, J B, Groop, L C, Boehnke, M, McCarthy, M I, Florez, J C & Barroso, I 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520
Nature genetics
U32
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Qi, L, Timpson, N J, Hayward, C, Vitart, V, Wild, S H, Morris, A, Rudan, I, Wright, A F & Campbell, H & Wilson, J F 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-116 . https://doi.org/10.1038/ng.520
Nature Genetics, 42(2), 105-116. Nature Publishing Group
Yarnell, J 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ' Nature Genetics, vol. 42, no. 2, pp. 105-119 . DOI: 10.1038/ng.520
Nature Genetics; Vol 42
Nature Genetics, 42(2), 105-U32. Nature Publishing Group
Nature genetics, vol. 42, no. 2, pp. 105-116
Nature Genetics, 42(5), 464-464
Nature Genetics, 42(2), 105
Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, A U, Wheeler, E, Glazer, N L, Bouatia-Naji, N, Gloyn, A L, Lindgren, C M, Mägi, R, Morris, A P, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, J J, Franklin, C S, Navarro, P, Song, K, Goel, A, Perry, J R B, Egan, J M, Lajunen, T, Grarup, N, Sparsø, T H, Doney, A, Voight, B F, Stringham, H M, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proença, C, Kumari, M, Lu, Q, Timpson, N J, Gieger, C, Zabena, C, Rocheleau, G, Ingelsson, E, An, P, O'Connell, J, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2010, ' New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk ', Nature Genetics, vol. 42, no. 2, pp. 105-16 . https://doi.org/10.1038/ng.520
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function
Autor:
Nahzinine Shakeri, Afshin Parsa, Mohammad M. Sajadi, Robert R. Redfield, Ruth E. Pakyz, Charles D. Howell, Rohit Talwani
Publikováno v:
Clinical and translational science. 4(4)
Background: HIV-1 natural viral suppressors (NVS) are individuals that control HIV replication without antiretrovirals (also know as HIV elite controllers). We have recently shown that these individuals have an elevated rate of hepatitis C virus (HCV