Výsledky vyhledávání - "Ruth E. Mirams"

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein*

Autor: Ruth E. Mirams, Justine M. Hill, Parimala R. Vajjhala

A key process underlying an innate immune response to pathogens or cellular stress is activation of members of the NOD-like receptor family, such as NLRP3, to assemble caspase-1-activating inflammasome complexes. Activated caspase-1 processes proinfl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3201c88b63967149a27559062e0148
https://europepmc.org/articles/PMC3516722/

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A structural and catalytic model for zinc phosphoesterases

Autor: Shiao Y. Chow, Ruth E. Mirams, Gerhard Schenk, Geoffrey B. Jameson, Lyall R. Hanton, Anneke Dorgelo, Morgan E. Etienne, Rebecca R. Buchholz, Sarah J. Smith, Lawrence R. Gahan

Publikováno v: Dalton transactions (Cambridge, England : 2003). (43)

A structural model for the active site of phosphoesterases, enzymes that degrade organophosphate neurotoxins, has been synthesised. The ligand [2-((2-hydroxy-3-(((2-hydroxyethyl)(pyridin-2-ylmethyl)amino)methyl)-5-methylbenzyl)(pyridin-2-ylmethyl)ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f861ff84baf9f84283bcf0ed60b42e7
https://pubmed.ncbi.nlm.nih.gov/19082062

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Synthesis and characterization of the tetranuclear iron(iii) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases

Autor: Lawrence R. Gahan, Ruth E. Mirams, Athanassios K. Boudalis, Allan G. Blackman, Robyn Aston, Sarah J. Smith, Mark J. Riley, Gerhard Schenk, Lyall R. Hanton

Publikováno v: Dalton Transactions. :5132

The ligand, 2-((2-hydroxy-5-methyl-3-((pyridin-2-ylmethylamino)methyl)benzyl)(2-hydroxybenzyl)amino)acetic acid (H(3)HPBA), which contains a donor atom set that mimics that of the active site of purple acid phosphatase is described. Reaction of H(3)H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5263026b063f898e2c7653e4f28723
https://doi.org/10.1039/b709293h

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Akademický článek

A structural and catalytic model for zinc phosphoesterasesElectronic supplementary information (ESI) available: TOF MS data. CCDC reference number 686253. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b806391e.

Autor: Rebecca R. Buchholz, Morgan E. Etienne, Anneke Dorgelo, Ruth E. Mirams, Sarah J. Smith, Shiao Yun Chow, Lyall R. Hanton, Geoffrey B. Jameson, Gerhard Schenk, Lawrence R. Gahan

Publikováno v: Dalton Transactions: An International Journal of Inorganic Chemistry; Oct2008, Vol. 2008 Issue 43, p6045-6054, 10p

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Akademický článek

Synthesis and characterization of the tetranuclear iron(iii) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases.

Autor: Athanassios K. Boudalis, Robyn E. Aston, Sarah J. Smith, Ruth E. Mirams, Mark J. Riley, Gerhard Schenk, Allan G. Blackman, Lyall R. Hanton, Lawrence R. Gahan

Publikováno v: Dalton Transactions: An International Journal of Inorganic Chemistry; Nov2007, Vol. 2007 Issue 44, p5132-5139, 8p

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