Výsledky vyhledávání - "Ruth Donohue"

Cyclodextrin gene vectors: cell trafficking and the influence of lipophilic chain length

Autor: Anthony Mcmahon, Caitriona M. O'Driscoll, Damien Forde, Ruth Donohue, E. Gomez, Raphael Darcy

Publikováno v: Scopus-Elsevier

Amphiphilic cyclodextrins (CDs) with various lipophilic chain lengths were used as vectors for transfection of Hep G2 hepatocytes in vitro . Transgene expression increased with increasing chain length. The most efficient cyclodextrin, heptakis[6-hexa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5470f5209762044dedcd801877de230
https://doi.org/10.1016/s1773-2247(08)50060-8

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Pyridylamino-β-cyclodextrin as a Molecular Chaperone for Lipopolysaccharide Embedded in a Multilayered Polyelectrolyte Architecture

Autor: Balázs Szalontai, Fouzia Boulmedais, Pascale Schwinté, Joelle Ogier, Jean-Claude Voegel, Ruth Donohue, Raphael Darcy, Philippe Lavalle, Nadia Jessel

Publikováno v: Advanced Functional Materials. 14:963-969

Layer-by-layer self-assembled polyelectrolyte films containing a charged cyclodextrin and lipopolysaccharide (LPS) are developed for the first time as a potential model for local endotoxin antagonist delivery. We have examined the biological activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc676b3ba4432b35b6d88e673299792
https://doi.org/10.1002/adfm.200305089

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Cationic cyclodextrin amphiphiles as gene delivery vectors

Autor: Bart Jan Ravoo, Ruth Donohue, Raphael Darcy, Caitriona M. O'Driscoll, Sally-Ann Cryan

Publikováno v: Journal of Drug Delivery Science and Technology. 14:57-62

Amphiphilic polycationic cyclodextrins, heptakis[2-(m-amino-oligoethyleneglycol)-6-deoxy-6-hexylthio]-p-cyclodextrin and heptakis[2-(m- amino-oligoethyleneglycol)-6-deoxy-6-hexadecylthio]-p-cyclodextrin, were assessed for condensation of plasmid DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::160c8b1cd774a4665fa6c1645c04a207
https://doi.org/10.1016/s1773-2247(04)50006-0

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Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin

Autor: Antonino Mazzaglia, Salvatore Sortino, Salvatore Petralia, Ruth Donohue, Raphael Darcy

Publikováno v: New journal of chemistry (1987) 27 (2003): 602–608. doi:10.1039/b209157g
info:cnr-pdr/source/autori:Sortino S.; Petralia S.; Darcy R. and Donohue R. and Mazzaglia A/titolo:Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin/doi:10.1039%2Fb209157g/rivista:New journal of chemistry (1987)/anno:2003/pagina_da:602/pagina_a:608/intervallo_pagine:602–608/volume:27

The effects of a novel cationic amphiphilic cyclodextrin (SC6CDNH2) on the photoprocesses of the phototoxic non-steroidal anti-inflammatory drug diflunisal (DF) have been investigated in aqueous medium. Association between DF and SC6CDNH2 was indicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266a175bd1aeac78e056e6434c98d209
https://doi.org/10.1039/b209157g

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[Untitled]

Autor: Antonino Mazzaglia, Bart Jan Ravoo, Luigi Monsù Scolaro, Ruth Donohue, Raphael Darcy

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 44:127-132

The entanglement process between porphyrins and some amphiphiliccyclodextrins and the occurrence of different species have been proved by the combination of UV-Visabsorption, fluorescence anisotropy, resonance light scattering and 1H NMR spectroscopy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9a3821c5e3a01b203710efd218edcdd
https://doi.org/10.1023/a:1023026109245

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Novel Amphiphilic Cyclodextrins: Graft-Synthesis of Heptakis(6-alkylthio-6-deoxy)-β-cyclodextrin 2-Oligo(ethylene glycol) Conjugates and Their ω-Halo Derivatives

Autor: Bart Jan Ravoo, Antonino Mazzaglia, Ruth Donohue, Raphael Darcy

Publikováno v: European Journal of Organic Chemistry. 2001:1715-1721

Novel amphiphilic cyclodextrins were synthesised by grafting oligo(ethylene glycol) units onto the secondary side of heptakis(6-alkylthio-6-deoxy)-β-cyclodextrins (alkyl = ethyl, hexyl, dodecyl and hexadecyl). The oligo(ethylene glycol) substituents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bbf7143f6194af887d5d70ddd9fd4f6
https://doi.org/10.1002/1099-0690(200105)2001:9<1715::aid-ejoc1715>3.0.co

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Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins

Autor: Martin J. O’Neill, Caitriona M. O'Driscoll, Eva Gomez, Damien Forde, Anthony Mcmahon, Raphael Darcy, Ruth Donohue

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[Objectives]: Achieving targeted delivery of gene medicines is desirable to maximise activity. Here, galactosylated amphiphilic cyclodextrins (CDs) are examined in terms of their ability to transfect asialoglycoprotein receptor-bearing HepG2 cells. [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b114a3bc83ec6a9dd57e071e7c0b5c82
https://pubmed.ncbi.nlm.nih.gov/22775209

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ChemInform Abstract: Novel Amphiphilic Cyclodextrins: Graft-Synthesis of Heptakis(6-alkylthio-6-deoxy)-β-cyclodextrin 2-Oligo(ethylene glycol) Conjugates and Their ω-Halo Derivatives

Autor: Bart Jan Ravoo, Ruth Donohue, Raphael Darcy, Antonino Mazzaglia

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec350785924fe6084125ec517dd9cc0a
https://doi.org/10.1002/chin.200206233

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Cell transfection with polycationic cyclodextrin vectors

Autor: Ann Holohan, Ruth Donohue, Sally-Ann Cryan, Raphael Darcy, Caitriona M. O'Driscoll

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 21(5)

Polycationic cyclodextrins (CDs) were complexed with plasmid DNA and their effectiveness as vectors was tested on COS-7 cells. These CDs were modified with pyridylamino, alkylimidazole, methoxyethylamino or primary amine groups at 6-positions of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b842692ec8affd222bc6db33d52c92
https://pubmed.ncbi.nlm.nih.gov/15066663

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