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Akademický článek

TGF-β Signaling Regulates the Differentiation of Motile Cilia

Autor: Janos Tözser, Ryan Earwood, Akiko Kato, Jacob Brown, Koichi Tanaka, Ruth Didier, Timothy L. Megraw, Martin Blum, Yoichi Kato

Publikováno v: Cell Reports, Vol 11, Iss 7, Pp 1000-1007 (2015)

The cilium is a small cellular organelle with motility- and/or sensory-related functions that plays a crucial role during developmental and homeostatic processes. Although many molecules or signal transduction pathways that control cilia assembly hav

Externí odkaz: https://doaj.org/article/41d74edfbd4045d8bb9ac34c0f0af899

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Akademický článek

Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery

Autor: Zhijian Cheng, Dale B. Bosco, Li Sun, Xiaoming Chen, Yunsheng Xu, Wenjiao Tai, Ruth Didier, Jinhua Li, Jianqing Fan, Xijing He, Yi Ren

Publikováno v: Cell Transplantation, Vol 26 (2017)

Spinal cord injury (SCI) causes functional impairment as a result of the initial injury followed by secondary injury mechanism. SCI provokes an inflammatory response that causes secondary tissue damage and neurodegeneration. While the use of neural s

Externí odkaz: https://doaj.org/article/111d20000db84239b30f318245a744ff

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Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication

Autor: Allaura S. Cone, David M. Gilbert, Angelica Medina, Hongjun Song, Yuna Son, Hengli Tang, Zhexing Wen, Margo A. Brinton, Guo Li Ming, Joseph C. Madden, Ernest Owen Nicandro Phillips, Sarah C. Ogden, Akash Gunjan, Christy Hammack, Chongchong Xu, Ruth Didier, Serena Giovinazzi

Publikováno v: Journal of Virology

Zika virus (ZIKV) infection attenuates the growth of human neural progenitor cells (hNPCs). As these hNPCs generate the cortical neurons during early brain development, the ZIKV-mediated growth retardation potentially contributes to the neurodevelopm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c5aff151da6c4a8db8ce565d2289a5

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Streamlined procedure for gene knockouts using all-in-one adenoviral CRISPR-Cas9

Autor: Ruth Didier, Hyunjeong Joo, Young Yang, Hyeongseok Kim, Yuanhu Jin, Kwangjun Lee, Heungsop Shin, Choogon Lee

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

CRISPR-Cas9 is a powerful gene editing technique that can induce mutations in a target gene of interest in almost any mammalian cell line. However, its practicality can be limited if target cell lines are difficult to transfect and do not proliferate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be2cd72bac6d7cf82e05a9586971e95
https://doi.org/10.1038/s41598-018-36736-y

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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Autor: Hengli Tang, Emily M. Lee, Jaehoon Shin, Ruth Didier, Guo Li Ming, Bing Yao, Yujing Li, Xuyu Qian, Hongjun Song, Zhexing Wen, Peng Jin, Christy Hammack, Sarah C. Ogden, Feiran Zhang, Kimberly M. Christian

Publikováno v: Cell Stem Cell. 18:587-590

SUMMARY The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f9e83de6be588759ffdde51269bbf
https://doi.org/10.1016/j.stem.2016.02.016

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Autor: Zarko Manojlovic, Oscar A. Cabrera, Ryan Earwood, Akiko Kato, Timothy L. Megraw, Branko Stefanovic, Diana Perez, Ruth Didier, Yoichi Kato

Publikováno v: Cilia

Background La-related protein 6 (LARP6) is an evolutionally conserved RNA-binding protein. Vertebrate LARP6 binds the 5′ stem-loop found in mRNAs encoding type I collagen to regulate their translation, but other target mRNAs and additional function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9106e3e33ef1175737a0c16523d097db
https://doi.org/10.1186/s13630-017-0047-7

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Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery

Autor: Zhijian Cheng, Jianqing Fan, Yunsheng Xu, Wenjiao Tai, Yi Ren, Dale B. Bosco, Jinhua Li, Ruth Didier, Xiaoming Chen, Xijing He, Li Sun

Publikováno v: Cell Transplantation, Vol 26 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a1d3fe144ccb1f20b352affd2104a7
https://pubmed.ncbi.nlm.nih.gov/27737726

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Genome-wide analysis of replication timing in mammalian cells: Troubleshooting problems encountered when comparing different cell types

Autor: David M. Gilbert, Ruth Didier, Vishnu Dileep

Publikováno v: Methods. 57:165-169

DNA is replicated in a defined temporal order that is developmentally regulated and constitutes a unique and stable fingerprint of a given cell type. Recently, we developed a robust assay to profile replication timing genome wide that can be applied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb0fa3ea6c5208ddeadb1ff4716b2e3
https://doi.org/10.1016/j.ymeth.2012.05.009

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