Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

Autor: Lea K Davis, Dongmei Yu, Clare L Keenan, Eric R Gamazon, Anuar I Konkashbaev, Eske M Derks, Benjamin M Neale, Jian Yang, S Hong Lee, Patrick Evans, Cathy L Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrio, Oscar J Bienvenu, Michael H Bloch, Rianne M Blom, Ruth D Bruun, Cathy L Budman, Beatriz Camarena, Desmond Campbell, Carolina Cappi, Julio C Cardona Silgado, Danielle C Cath, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, David V Conti, Edwin H Cook, Vladimir Coric, Bernadette A Cullen, Dieter Deforce, Richard Delorme, Yves Dion, Christopher K Edlund, Karin Egberts, Peter Falkai, Thomas V Fernandez, Patience J Gallagher, Helena Garrido, Daniel Geller, Simon L Girard, Hans J Grabe, Marco A Grados, Benjamin D Greenberg, Varda Gross-Tsur, Stephen Haddad, Gary A Heiman, Sian M J Hemmings, Ana G Hounie, Cornelia Illmann, Joseph Jankovic, Michael A Jenike, James L Kennedy, Robert A King, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L Lowe, Fabio Macciardi, James T McCracken, Lauren M McGrath, Sandra C Mesa Restrepo, Rainald Moessner, Jubel Morgan, Heike Muller, Dennis L Murphy, Allan L Naarden, William Cornejo Ochoa, Roel A Ophoff, Lisa Osiecki, Andrew J Pakstis, Michele T Pato, Carlos N Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias J Renner, Victor I Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, Maria C Rosàrio, David Rosenberg, Guy A Rouleau, Stephan Ruhrmann, Andres Ruiz-Linares, Aline S Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey S Singer, Jan H Smit, Dan J Stein, E Strengman, Jay A Tischfield, Ana V Valencia Duarte, Homero Vallada, Filip Van Nieuwerburgh, Jeremy Veenstra-Vanderweele, Susanne Walitza, Ying Wang, Jens R Wendland, Herman G M Westenberg, Yin Yao Shugart, Euripedes C Miguel, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L Hanna, Peter Heutink, Damiaan Denys, Paul D Arnold, Ben A Oostra, Gerald Nestadt, Nelson B Freimer, David L Pauls, Naomi R Wray, S Evelyn Stewart, Carol A Mathews, James A Knowles, Nancy J Cox, Jeremiah M Scharf

Publikováno v: PLoS Genetics, Vol 9, Iss 10, p e1003864 (2013)

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quanti

Externí odkaz: https://doaj.org/article/dcefb124869a49fdb60299acf97e56f6

De Novo Coding Variants Are Strongly Associated with Tourette Disorder

Autor: A. Jeremy Willsey, Thomas V. Fernandez, Dongmei Yu, Robert A. King, Andrea Dietrich, Jinchuan Xing, Stephan J. Sanders, Jeffrey D. Mandell, Alden Y. Huang, Petra Richer, Louw Smith, Shan Dong, Kaitlin E. Samocha, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jay A. Tischfield, Jeremiah M. Scharf, Matthew W. State, Gary A. Heiman, Mohamed Abdulkadir, Julia Bohnenpoll, Yana Bromberg, Lawrence W. Brown, Keun-Ah Cheon, Barbara J. Coffey, Li Deng, Lonneke Elzerman, Odette Fründt, Blanca Garcia-Delgar, Erika Gedvilaite, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Pieter J. Hoekstra, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G. Ludolph, Claudia Lühr da Silva, Marcos Madruga-Garrido, Athanasios Maras, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L. Murphy, Cara Nasello, Thaïra J.C. Openneer, Kerstin J. Plessen, Veit Roessner, Stephan Sanders, Eun-Young Shin, Deborah A. Sival, Dong-Ho Song, Jungeun Song, Anne Marie Stolte, Nawei Sun, Jennifer Tübing, Frank Visscher, Michael F. Walker, Sina Wanderer, Shuoguo Wang, Martin Woods, Yeting Zhang, Anbo Zhou, Samuel H. Zinner, Cathy L. Barr, James R. Batterson, Cheston Berlin, Ruth D. Bruun, Cathy L. Budman, Danielle C. Cath, Sylvain Chouinard, Nancy J. Cox, Sabrina Darrow, Lea K. Davis, Yves Dion, Nelson B. Freimer, Marco A. Grados, Matthew E. Hirschtritt, Cornelia Illmann, Roger Kurlan, James F. Leckman, Gholson J. Lyon, Irene A. Malaty, William M. MaMahon, Michael S. Okun, Lisa Osiecki, David L. Pauls, Danielle Posthuma, Vasily Ramensky, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Harvey S. Singer, Jan Smit, Jae-Hoon Sul

Publikováno v: Neuron, 94(3), 486-499.e9. Cell Press
Neuron, 94(3), 486-499. CELL PRESS
Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG) & Tourette Syndrome Association International Consortium for Genetics (TSAICG) 2017, ' De Novo Coding Variants Are Strongly Associated with Tourette Disorder ', Neuron, vol. 94, no. 3, pp. 486-499.e9 . https://doi.org/10.1016/j.neuron.2017.04.024

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bf2171326355ecbabd84b960987ed8
https://research.vumc.nl/en/publications/18bfb71f-ac38-4f98-a918-ec109167ddb0

Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD

Autor: Mary M. Robertson, Peter Heutink, Leonhard Lennertz, Victor I. Reus, John Hardy, Mark A. Riddle, Beatriz Camarena, Helena Garrido, Robert A. King, Simon Girard, Christine Lochner, Michael H. Bloch, Patrick Evans, Anuar Konkashbaev, Jack Samuels, Priya Moorjani, Chiara Sabatti, Andrew J. Pakstis, Ying Wang, O. Joseph Bienvenu, Richard Delorme, David L. Pauls, Rainald Moessner, Gary A. Heiman, Daniel A. Geller, Marco A. Grados, Eric R. Gamazon, John Piacentini, Dan J. Stein, William Cornejo Ochoa, Maria Conceição do Rosário, Karin Egberts, Thomas L. Lowe, Christopher K. Edlund, Jan Smit, Christopher Pittenger, Denise A. Chavira, Marion Leboyer, Homero Vallada, Sandra Catalina Mesa Restrepo, Jacquelyn Crane, Donald W. Black, David V. Conti, Paul Sandor, Humberto Nicolini, Lisa Osiecki, Jeremy Veenstra-VanderWeele, Catherine Mayerfeld, Danielle Posthuma, Edna Grünblatt, Carolina Cappi, Robert B. Weiss, Cristina Barlassina, Sara Lupoli, Chunyu Liu, Sian M. J. Hemmings, Ben A. Oostra, D. Denys, Susanne Walitza, Lea K. Davis, Stephen A. Haddad, Luis Diego Herrera, Jubel Morgan, Hans Joergen Grabe, Benjamin M. Neale, Thomas V. Fernandez, Yehuda Pollak, Roel A. Ophoff, Gerald Nestadt, Harvey S. Singer, Stephan Ruhrmann, Bernadette Cullen, Michael Wagner, Nuria Lanzagorta, Jeremiah M. Scharf, Cathy L. Budman, Ruth D. Bruun, R. Kurlan, Valsama Eapen, Jesen Fagerness, Desmond Campbell, James L. Kennedy, Carlos N. Pato, Nancy J. Cox, Pieter J. Hoekstra, Joseph Jankovic, Cathy L. Barr, Peter Falkai, Donald L. Gilbert, Fortu Benarroch, Dianne M. Hezel, Maria Cristina Cavallini, Brooke Sheppard, Fabio Macciardi, William M. McMahon, Laura Bellodi, Maurizio Turiel, Wolfgang Maier, Varda Gross-Tsur, Helena Brentani, Dongmei Yu, Danielle C. Cath, Ana V. Valencia Duarte, Eduardo Fournier, James A. Knowles, Tobias J. Renner, Erika L. Nurmi, Guy A. Rouleau, Benjamin D. Greenberg, Nelson B. Freimer, Shaun Purcell, Patience J. Gallagher, Roxana Romero, Gregory L. Hanna, Paolo Manunta, Edwin H. Cook, Michele T. Pato, Sylvain Chouinard, Scott L. Rauch, James T. McCracken, Gloria Gerber, Carol A. Mathews, Jens R. Wendland, Sampath Arepalli, Dennis L. Murphy, Daniele Cusi, Barbara Kremeyer, Vladimir Coric, Aline S. Sampaio, Erika Salvi, Julio C. Cardona Silgado, Cornelia Illmann, James F. Leckman, Euripedes Constantino Miguel, H. Müller, Yin Yao Shugart, Eric Strengman, Ana Gabriela Hounie, Michael E. Weale, Gabriel Bedoya Berrió, Margaret A. Richter, Maurizio Marconi, Allan L. Naarden, Michael A. Jenike, M.R. Cookson, David R. Rosenberg, Andres Ruiz-Linares, S. Evelyn Stewart, Paul D. Arnold, H.G.M. Westenberg, Yves Dion, Jay A. Tischfield, Eske M. Derks, Lauren M. McGrath

Publikováno v: American Journal of Psychiatry, 172(1), 82-93. American Psychiatric Association
The American Journal of Psychiatry, 172(1), 82-93. American Psychiatric Association
The American journal of psychiatry 172(1), 82-93 (2015). doi:10.1176/appi.ajp.2014.13101306
Yu, D M, Mathews, C A, Scharf, J M, Neale, B M, Davis, L K, Gamazon, E R, Derks, E M, Evans, P, Edlund, C K, Crane, J, Osiecki, L, Gallagher, P, Gerber, G, Haddad, S, Illmann, C, McGrath, L M, Mayerfeld, C, Arepalli, S, Barlassina, C, Barr, C L, Bellodi, L, Benarroch, F, Berrio, G B, Bienvenu, O J, Black, D W, Bloch, M H, Brentani, H, Bruun, R D, Budman, C L, Camarena, B, Campbell, D D, Cappi, C, Silgado, J C C, Cavallini, M C, Chavira, D A, Chouinard, S, Cook, E H, Cookson, M R, Coric, V, Cullen, B, Cusi, D, Delorme, R, Denys, D, Dion, Y, Eapen, V, Egberts, K, Falkai, P, Fernandez, T, Fournier, E, Garrido, H, Geller, D, Gilbert, D L, Girard, S L, Grabe, H J, Grados, M A, Greenberg, B D, Gross-Tsur, V, Grunblatt, E, Hardy, J, Heiman, G A, Hemmings, S M J, Herrera, L D, Hezel, D M, Hoekstra, P J, Jankovic, J, Kennedy, J L, King, R A, Konkashbaev, A I, Kremeyer, B, Kurlan, R, Lanzagorta, N, Leboyer, M, Leckman, J F, Lennertz, L, Liu, C Y, Lochner, C, Lowe, T L, Lupoli, S, Macciardi, F, Maier, W, Manunta, P, Marconi, M, McCracken, J T, Restrepo, S C M, Moessner, R, Moorjani, P, Morgan, J, Muller, H, Murphy, D L, Naarden, A L, Nurmi, E, Ochoa, W C, Ophoff, R A, Pakstis, A J, Pato, M T, Pato, C N, Piacentini, J, Pittenger, C, Pollak, Y, Smit, J H, Posthuma, D, Cox, N J & Pauls, D L 2015, ' Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD ', American Journal of Psychiatry, vol. 172, no. 1, pp. 82-93 . https://doi.org/10.1176/appi.ajp.2014.13101306
American Journal of Psychiatry, 172(1), 82-93. AMER PSYCHIATRIC PUBLISHING, INC
American Journal of Psychiatry, 172(1), 82. American Psychiatric Association
American journal of psychiatry, 172(1), 82-93. American Psychiatric Association

Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e11312ccf27a5c74965ba6942d3999
https://pure.eur.nl/en/publications/c4492f78-db9b-4995-8b7c-16801f9e814c

Paroxetine Treatment of Episodic Rages Associated With Tourette's Disorder

Autor: Ruth D. Bruun, Cathy L. Budman

Publikováno v: The Journal of Clinical Psychiatry. 59:581-584

Background Episodic rages have been estimated to occur in as many as 30% of patients with Tourette's syndrome (Tourette's disorder), but their treatment has never been systematically investigated. We report on the results of an open-label pilot study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb4a95dfbfe2dc0efa8a06f1aba5b7a
https://doi.org/10.4088/jcp.v59n1104

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

Autor: Patrick Evans, Jay A. Tischfield, Anuar Konkashbaev, Richard Delorme, Sandra Catalina Mesa Restrepo, Margaret A. Richter, Gregory L. Hanna, Allan L. Naarden, Michele T. Pato, Jian Yang, Denise A. Chavira, Damiaan Denys, Paul Sandor, Michael A. Jenike, Sian M. J. Hemmings, Paul D. Arnold, Stephan Ruhrmann, H.G.M. Westenberg, Yves Dion, Cathy L. Barr, Andres Ruiz-Linares, Brooke Sheppard, Leonhard Lennertz, Eske M. Derks, Lauren M. McGrath, Barbara Kremeyer, Marion Leboyer, Victor I. Reus, Cornelia Illmann, S. Evelyn Stewart, Dan J. Stein, Ana Gabriela Hounie, James T. McCracken, R. Kurlan, Chunyu Liu, Aline S. Sampaio, Thomas L. Lowe, Benjamin M. Neale, Yehuda Pollak, Desmond Campbell, Fabio Macciardi, Mary M. Robertson, Benjamin D. Greenberg, Ben A. Oostra, Rainald Moessner, Gary A. Heiman, Nuria Lanzagorta, Sylvain Chouinard, Rianne M. Blom, Karin Egberts, Carlos N. Pato, David V. Conti, Carol A. Mathews, Ying Wang, Marco A. Grados, Julio C. Cardona Silgado, S. Hong Lee, H. Müller, Eric R. Gamazon, Humberto Nicolini, Jan Smit, Euripedes Constantino Miguel, Jens R. Wendland, Cathy L. Budman, Laura Bellodi, Danielle Posthuma, Jubel Morgan, David R. Rosenberg, John Piacentini, Hans J. Grabe, Mark A. Riddle, Beatriz Camarena, Naomi R. Wray, Eric Strengman, Dennis L. Murphy, Simon Girard, Christine Lochner, Ruth D. Bruun, Joseph Jankovic, Edwin H. Cook, William M. McMahon, Scott L. Rauch, James F. Leckman, Peter Falkai, Fortu Benarroch, Christopher K. Edlund, Gabriel Bedoya Berrío, Homero Vallada, Susanne Walitza, Nelson B. Freimer, Stephen A. Haddad, Yin Yao Shugart, Danielle C. Cath, Nancy J. Cox, Varda Gross-Tsur, Guy A. Rouleau, Bernadette Cullen, Michael H. Bloch, Dieter Deforce, David L. Pauls, Thomas V. Fernandez, Roel A. Ophoff, Filip Van Nieuwerburgh, Gerald Nestadt, Dongmei Yu, Helena Garrido, Robert A. King, James L. Kennedy, Clare L. Keenan, Lisa Osiecki, Jack Samuels, Jeremy Veenstra-VanderWeele, Ana V. Valencia Duarte, James A. Knowles, Patience J. Gallagher, Carolina Cappi, Maria Conceição do Rosário, Andrew J. Pakstis, Christopher Pittenger, Michael Wagner, Jeremiah M. Scharf, Daniel A. Geller, Vladimir Coric, Tobias J. Renner, Oscar J. Bienvenu, Roxana Romero, William Cornejo Ochoa, Peter Heutink, Lea K. Davis, Harvey S. Singer, Maria Cristina Cavallini

Publikováno v: Davis, L K, Yu, D, Keenan, C L, Gamazon, E R, Konkashbaev, A I, Derks, E M, Neale, B M, Yang, J, Lee, S H, Evans, P, Barr, C L, Bellodi, L, Benarroch, F, Berrio, G B, Bienvenu, O J, Bloch, M H, Blom, R M, Bruun, R D, Budman, C L, Camarena, B, Campbell, D, Cappi, C, Cardona Silgado, J C, Cath, D C, Cavallini, M C, Chavira, D A, Chouinard, S, Conti, D V, Cook, E H, Coric, V, Cullen, B A, Deforce, D, Delorme, R, Dion, Y, Edlund, C K, Egberts, K, Falkai, P, Fernandez, T V, Gallagher, P J, Garrido, H, Geller, D, Girard, S L, Grabe, H J, Grados, M A, Greenberg, B D, Gross-Tsur, V, Haddad, S, Heiman, G A, Hemmings, S M, Hounie, A G, Illmann, C, Jankovic, J, Jenike, M A, Kennedy, J L, King, R A, Kremeyer, B, Kurlan, R, Lanzagorta, N, Leboyer, M, Leckman, J F, Lennertz, L, Liu, C, Lochner, C, Lowe, T L, Macciardi, F, McCracken, J T, McGrath, L M, Mesa Restrepo, S C, Moessner, R, Morgan, J, Muller, H, Murphy, D L, Naarden, A L, Ochoa, W C, Ophoff, R A, Osiecki, L, Pakstis, A J, Pato, M T, Piacentini, J, Pittenger, C, Pollak, Y, Rauch, S L, Renner, T J, Reus, V I, Richter, M A, Riddle, M A, Robertson, M M, Romero, R, Rosàrio, M C, Rosenberg, D, Rouleau, G A, Ruhrmann, S, Ruiz-Linares, A, Sampaio, A S, Samuels, J, Sandor, P, Sheppard, B, Singer, H S, Smit, J H, Stein, D J, Strengman, E, Tischfield, J A, Valencia Duarte, A V, Vallada, H, van Nieuwerburgh, F, Veenstra-Vanderweele, J, Walitza, S, Wang, Y, Wendland, J R, Westenberg, H G, Shugart, Y Y, Miguel, E C, McMahon, W, Wagner, M, Nicolini, H, Posthuma, D, Hanna, G L, Heutink, P, Denys, D, Arnold, P D, Oostra, B A, Nestadt, G, Freimer, N B, Pauls, D L, Wray, N R, Stewart, S E, Mathews, C A, Knowles, J A, Cox, N J & Scharf, J M 2013, ' Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture ', PLoS Genetics, vol. 9, no. 10, e1003864, pp. e1003864 . https://doi.org/10.1371/journal.pgen.1003864
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Genetics
PLoS Genetics, Vol 9, Iss 10, p e1003864 (2013)
PLoS Genetics 9(10), e1003864 (2013). doi:10.1371/journal.pgen.1003864
PLoS Genetics, 9(10):e1003864. Public Library of Science
PLOS Genetics
Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
PLOS GENETICS
PLoS Genetics (print), 9(10). Public Library of Science
PLoS genetics, 9(10). Public Library of Science
Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686a4341f35ee18e526d61a0482fccdd
https://research.vumc.nl/en/publications/c9466bc4-c7d4-4632-bd50-3178b290bbeb