DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Autor: Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)

Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highl

Externí odkaz: https://doaj.org/article/7174fcff49ec4c968e5c2cd9447b8742

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

Autor: Helena M. Izquierdo, Paola Brandi, Manuel-José Gómez, Ruth Conde-Garrosa, Elena Priego, Michel Enamorado, Sarai Martínez-Cano, Iria Sánchez, Laura Conejero, Daniel Jimenez-Carretero, Silvia Martín-Puig, Martin Guilliams, David Sancho

Publikováno v: Cell Reports, Vol 24, Iss 7, Pp 1738-1746 (2018)

Summary: The rapid transit from hypoxia to normoxia in the lung that follows the first breath in newborn mice coincides with alveolar macrophage (AM) differentiation. However, whether sensing of oxygen affects AM maturation and function has not been

Externí odkaz: https://doaj.org/article/c9d11d4f274940618ebe34423d921468

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Autor: Alexis J. Combes, Santiago Zelenay, Christian P. Bromley, Matthew F. Krummel, Ignacio Melero, Paola Brandi, Alfonso R. Sánchez-Paulete, Carlos del Fresno, Manuel Gómez, Elena Hernández-García, Francisco J. Cueto, Michel Enamorado, Ruth Conde-Garrosa, Salvador Iborra, David Sancho, Santos Mañes

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Bromley, C 2021, ' DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells ', Journal for ImmunoTherapy of Cancer . https://doi.org/10.1136/jitc-2020-002054
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for immunotherapy of cancer, vol 9, iss 5

Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e719150dc3d908f46d05f4443ec98bd
http://hdl.handle.net/20.500.12105/15091

Leishmania Triggering of SHP-1 in Dendritic Cells Inhibits Antigen Cross-Presentation to Cd8 + T Cells

Autor: Sofía C. Khouili, Ruth Conde-Garrosa, Elena Hernández-García, Salvador Iborra, Emma C. L. Cook, María Martínez-López

Publikováno v: SSRN Electronic Journal.

Pathogens that establish intracellular niches may have evolved strategies to prevent their detection by cytotoxic CD8+ T lymphocytes (CTL), which in some cases requires antigen cross-presentation by dendritic cells (DC). Here, we asked whether Leishm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fbd9e3c908c56520dcfb695c17a0ad3
https://doi.org/10.2139/ssrn.3645487

Microbiota sensing by mincle-myk axis in dendritic cells regulates Interleukin-17 and-22 production and promotes intestinal barrier integrity

Autor: Camille Danne, Francisco J. Rupérez, Andrzej Dzionek, María Martínez-López, Benjamin Kemp, Nadine Cerf-Bensussan, Delyth M. Reid, Matthew J. Robinson, Paula Saz-Leal, Annalaura Mastrangelo, David Sancho, Emma Slack, Lara Minnerup, Javier P. Gisbert, Elizabeth R. Mann, Salomé LeibundGut-Landmann, Salvador Iborra, Valérie Gaboriau-Routhiau, María Chaparro, Gordon D. Brown, María M. Lorenzo, David Bernardo, Ruth Conde-Garrosa

Publikováno v: Immunity
Immunity, 2019, 50 (2), pp.1-26. ⟨10.1016/j.immuni.2018.12.020⟩
Immunity, 50 (2)
Immunity, Elsevier, 2019, 50 (2), pp.1-26. ⟨10.1016/j.immuni.2018.12.020⟩
Martínez-López, M, Iborra, S, Conde-Garrosa, R, Mastrangelo, A, Danne, C, Mann, E R, Reid, D M, Gaboriau-Routhiau, V, Chaparro, M, Lorenzo, M P, Minnerup, L, Saz-Leal, P, Slack, E, Kemp, B, Gisbert, J P, Dzionek, A, Robinson, M J, Rupérez, F J, Cerf-Bensussan, N, Brown, G D, Bernardo, D, LeibundGut-Landmann, S & Sancho, D 2019, ' Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and-22 Production and Promotes Intestinal Barrier Integrity ', Immunity, vol. 50, no. 2, pp. 446-461.e9 . https://doi.org/10.1016/j.immuni.2018.12.020
Repisalud
Instituto de Salud Carlos III (ISCIII)

Summary Production of interleukin-17 (IL-17) and IL-22 by T helper 17 (Th17) cells and group 3 innate lymphoid cells (ILC3s) in response to the gut microbiota ensures maintenance of intestinal barrier function. Here, we examined the mechanisms whereb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b83b99d9cc1eb3295ac1bfb69f65ea
https://hal.inrae.fr/hal-02626234