Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruth Cohen-Khait"'
Autor:
Ruth Cohen-Khait, Ameya Harmalkar, Phuong Pham, Melissa N. Webby, Nicholas G. Housden, Emma Elliston, Jonathan T. S. Hopper, Shabaz Mohammed, Carol V. Robinson, Jeffrey J. Gray, Colin Kleanthous
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Decades of excessive use of readily available antibiotics has generated a global problem of antibiotic resistance and, hence, an urgent need for novel antibiotic solutions. Bacteriocins are protein-based antibiotics produced by bacteria to eliminate
Externí odkaz:
https://doaj.org/article/ddb60eae05714b6dafbaa4cb0b0c7b94
Autor:
Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Dawei Sun, Pooja Sridhar, Timothy J. Knowles, Colin Kleanthous, Waldemar Vollmer
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial to the maintenance of cellular integrity and enable survival in challenging environments1–5. The functionality of the outer membrane relies on out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fab2eae81711632e6e49c3eca0c0e53
https://doi.org/10.1101/2022.04.11.487844
https://doi.org/10.1101/2022.04.11.487844
Autor:
Jeffrey J. Gray, Ruth Cohen-Khait, Emma Elliston, Carol V. Robinson, Shabaz Mohammed, Jonathan T. S. Hopper, Ameya Harmalkar, Melissa N. Webby, Colin Kleanthous, Phuong Pham, Nicholas G. Housden
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Colicins are protein antibiotics deployed by Escherichia coli to eliminate competing strains. Colicins frequently exploit outer membrane (OM) nutrient transporters to penetrate the selectively permeable bacterial cell envelope. Here, by applying live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f25d245e93b81e454ff2e64a899702
https://doi.org/10.1128/mbio.01787-21
https://doi.org/10.1128/mbio.01787-21
Autor:
Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G. Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J. Knowles, Colin Kleanthous, Waldemar Vollmer
Publikováno v:
Nature. 606(7916)
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and enable survival in challenging environments1–5. The function of the outer membrane is dependent on o
Autor:
Dawei Sun, Renata Kaminska, Gideon Mamou, Jian Payandeh, Patrick George Inns, Kelly M. Storek, Colin Kleanthous, Ruth Cohen-Khait, Steven T. Rutherford, Helen Miller, Nicholas G. Housden
The outer membrane (OM) of Gram-negative bacteria is a robust protective barrier that excludes major classes of antibiotics. The assembly, integrity and functioning of the OM is dependent on β-barrel outer membrane proteins (OMPs), the insertion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54ab0f2c691d8ff7f1aeb6cb452ba90
https://doi.org/10.1101/2021.01.27.428258
https://doi.org/10.1101/2021.01.27.428258
Autor:
Ruth Cohen-Khait, Gideon Schreiber
Publikováno v:
Biochemistry. 57:4644-4650
Protein-protein interactions mediate the vast majority of cellular processes. Though protein interactions obey basic chemical principles also within the cell, the in vivo physiological environment may not allow for equilibrium to be reached. Thus, in
Autor:
Ruth Cohen-Khait, Gideon Schreiber
Publikováno v:
Proceedings of the National Academy of Sciences. 113:14982-14987
Protein-protein interactions occur via well-defined interfaces on the protein surface. Whereas the location of homologous interfaces is conserved, their composition varies, suggesting that multiple solutions may support high-affinity binding. In this
Autor:
Ruth Cohen-Khait
Publikováno v:
Nature Reviews Microbiology. 19:76-76
This month’s Under the Lens discusses the application of high-speed atomic force microscopy to image fragile bacterial membrane vesicles by briefly touching them with a gentle tapping force, revealing species-specific heterogeneity in membrane vesi
Publikováno v:
Structure (London, England : 1993). 25(12)
Summary Proteins have evolved to balance efficient binding of desired partners with rejection of unwanted interactions. To investigate the evolution of protein-protein interactions, we selected a random library of pre-stabilized TEM1 β-lactamase aga