Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Ruth Brenk"'
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0294827 (2024)
Neutrophil proteinase 3 (PR3) is an important drug target for inflammatory lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Drug discovery efforts targeting PR3 require active enzyme for in vitro characterization, such
Externí odkaz:
https://doaj.org/article/fc1527840d6345d0bbe0675811fd2772
Autor:
Sebastian Bothe, Petra Hänzelmann, Stephan Böhler, Josef Kehrein, Markus Zehe, Christoph Wiedemann, Ute A. Hellmich, Ruth Brenk, Hermann Schindelin, Christoph Sotriffer
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-15 (2022)
The AAA+ ATPase p97 protein is thought to be a potential anticancer target, but direct targeting on its ATPase function has not proven to be a successful strategy in clinical trials due to lack of selectivity. Here, the authors use biolayer interfero
Externí odkaz:
https://doaj.org/article/52166a37c754406fb4c47ec7d205d22e
Autor:
Sudarshan S. Patil, Vipul Panchal, Trude Røstbø, Sofya Romanyuk, Hanne Hollås, Ruth Brenk, Ann Kari Grindheim, Anni Vedeler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of transport vesicles and mRNA gran
Externí odkaz:
https://doaj.org/article/fe94637ba7a64aaba615f5c71146eff2
Publikováno v:
F1000Research, Vol 10 (2022)
Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of malonyl-ACP (acyl carrier protein
Externí odkaz:
https://doaj.org/article/482b73bf4fea4065b182071c5c2b13f9
Autor:
Lina Irsheid, Thomas Wehler, Christoph Borek, Werner Kiefer, Ruth Brenk, Maria Elena Ortiz-Soto, Jürgen Seibel, Tanja Schirmeister
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216132 (2019)
Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates with the progression of tu
Externí odkaz:
https://doaj.org/article/4c10653b62ac42bd84921c63fc111225
Autor:
Vipul Panchal, Ruth Brenk
Publikováno v:
Antibiotics, Vol 10, Iss 1, p 45 (2021)
Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules. Since their discovery at the beginning of this century, riboswitches have been regarded
Externí odkaz:
https://doaj.org/article/df56824b175547a4b30cb589ee2f60bd
Autor:
Raphael Klein, Laura Cendron, Martina Montanari, Pierangelo Bellio, Giuseppe Celenza, Lorenzo Maso, Donatella Tondi, Ruth Brenk
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 304 (2020)
The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A carbapenemases include membe
Externí odkaz:
https://doaj.org/article/51c2294a4bc94e29ace2da1468acbd72
Autor:
Raphael Klein, Pasquale Linciano, Giuseppe Celenza, Pierangelo Bellio, Sofia Papaioannou, Jesus Blazquez, Laura Cendron, Ruth Brenk, Donatella Tondi
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0203241 (2018)
Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad
Externí odkaz:
https://doaj.org/article/52763062b4fa47ef8e491ae03bbcd7af
Autor:
Aurijit Sarkar, Ruth Brenk
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137279 (2015)
Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore sought after. To this end, we su
Externí odkaz:
https://doaj.org/article/3c5587d23eee4ba382d5316de1811ac7
Autor:
Naomi Tidten-Luksch, Raffaella Grimaldi, Leah S Torrie, Julie A Frearson, William N Hunter, Ruth Brenk
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35792 (2012)
CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species of bacteria and apicomplexan parasites. IspE has been shown to be essential by genetic metho
Externí odkaz:
https://doaj.org/article/14264151614b4874805851abdf583349