Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Ruth Brack‐Werner"'
Autor:
Amelie Bauer, Matteo Puglisi, Dennis Nagl, Joel A Schick, Thomas Werner, Andreas Klingl, Jihad El Andari, Veit Hornung, Horst Kessler, Magdalena Götz, Dirk Grimm, Ruth Brack‐Werner
Publikováno v:
Advanced Science, Vol 9, Iss 16, Pp n/a-n/a (2022)
Abstract Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte‐centered diseases requires efficient and well‐characterized gene transfer vectors. Vectors derived fr
Externí odkaz:
https://doaj.org/article/5af49d6d446a4dbebfe51b5777d11b6c
Autor:
Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replica
Externí odkaz:
https://doaj.org/article/173953915c6a47688637a8c938baf515
Autor:
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack‐Werner, Sabrina Schreiner
Publikováno v:
Advanced Science, Vol 7, Iss 8, Pp n/a-n/a (2020)
Abstract Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis. In the absence of protective immunity, as in allogeneic bone marrow transplant patients, H
Externí odkaz:
https://doaj.org/article/965de59d17624f1788412f54eaf49a86
Autor:
Stephan Hofmann, Sandra Dehn, Ramona Businger, Sebastian Bolduan, Martha Schneider, Zeger Debyser, Ruth Brack-Werner, Michael Schindler
Publikováno v:
Open Biology, Vol 7, Iss 10 (2017)
Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restrictio
Externí odkaz:
https://doaj.org/article/70ebca8f138848489ed7100eb817bab1
Publikováno v:
BioTechniques, Vol 41, Iss 6, Pp 688-692 (2006)
Externí odkaz:
https://doaj.org/article/58adc342042646cab02438ac546f2c44
Autor:
Stephan Kremb, Markus Helfer, Birgit Kraus, Horst Wolff, Christian Wild, Martha Schneider, Christian R Voolstra, Ruth Brack-Werner
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103895 (2014)
In recent years, marine algae have emerged as a rich and promising source of molecules with potent activities against various human pathogens. The widely distributed brown alga Lobophora variegata that is often associated with tropical coral reefs ex
Externí odkaz:
https://doaj.org/article/2104067e1eff4ce89e999f644e5854da
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105478 (2014)
The TAR DNA binding protein (TDP-43) was originally identified as a host cell factor binding to the HIV-1 LTR and thereby suppressing HIV-1 transcription and gene expression (Ou et al., J.Virol. 1995, 69(6):3584). TDP-43 is a global regulator of tran
Externí odkaz:
https://doaj.org/article/9f354b96b024416192ae5c71ecf7de83
The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor.
Autor:
Markus Helfer, Herwig Koppensteiner, Martha Schneider, Stephanie Rebensburg, Sara Forcisi, Constanze Müller, Philippe Schmitt-Kopplin, Michael Schindler, Ruth Brack-Werner
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87487 (2014)
Global HIV-1 treatment would benefit greatly from safe herbal medicines with scientifically validated novel anti-HIV-1 activities. The root extract from the medicinal plant Pelargonium sidoides (PS) is licensed in Germany as the herbal medicine EPs®
Externí odkaz:
https://doaj.org/article/95a764721ac64e8dbfff51198a77bb5e
Autor:
Aubrie O’Rourke, Stephan Kremb, Theresa Maria Bader, Markus Helfer, Philippe Schmitt-Kopplin, William H. Gerwick, Ruth Brack-Werner, Christian R. Voolstra
Publikováno v:
Marine Drugs, Vol 14, Iss 2, p 28 (2016)
The sponge Stylissa carteri is known to produce a number of secondary metabolites displaying anti-fouling, anti-inflammatory, and anti-cancer activity. However, the anti-viral potential of metabolites produced by S. carteri has not been extensively e
Externí odkaz:
https://doaj.org/article/40189f27030e449ea734b14f8d937119
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4155 (2009)
BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN), catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN rem
Externí odkaz:
https://doaj.org/article/a6a92478f58b46f19a79b1d9aac796fa