Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ruth B. Katz"'
Autor:
Nicholas David Tyrrell, and Ruth B. Katz, Robin Mark Bannister, Brookes Michael Handforth, Graham Evans
Publikováno v:
Organic Process Research & Development. 4:467-472
A versatile route to single enantiomer verapamil from readily available raw materials is described. The key intermediate, 4-cyano-4-(3,4-dimethoxyphenyl)-5-methyl hexanoic acid (verapamilic acid), was resolved efficiently with α-methyl benzylamine.
Publikováno v:
Pesticide Science. 50:258-274
A previous investigation established that compounds containing a guanidinium or amidinium grouping are effective inhibitors of sterol Δ8–Δ7 isomerase and/or Δ14 reductase activity in plant pathogenic fungi. A binding model for known fungicidal i
Autor:
Graham Anthony Charles Frampton, Indrani Woollam, Ruth B. Katz, Ian Harold Smith, Neil Tremayne, Duncan Hannah, Robert John Watson, Neil Henderson
Publikováno v:
Organic Process Research & Development. 8:415-417
The synthesis of the matrix metalloproteinase (MMP) inhibitor CH8757 is described. The discovery route has been modified to incorporate a three-stage one-pot sequence using α,α,α-trifluorotoluene as solvent. The formation of the hydroxamic acid us
Publikováno v:
Pesticide Science. 44:341-355
A novel class of chemical has been designed with the aim of inhibiting the Δ 14 -reductase and Δ 8 -Δ 7 -isomerase enzymes in the ergosterol biosynthesis pathway in fungi. Use was made of knowledge about the mechanisms of both enzymes and the mode
Publikováno v:
ChemInform. 24
The title compounds were prepared by variations of a route in which the principal stages include conversion of N-substituted pyrrolidine-2-thiones 6 into vinylogous urethanes 10 , which undergo subsequent cycloacylation. A related approach that uses
Publikováno v:
ChemInform. 24
Condensation of 3-arylated Δ 1 -pyrrolinium salts with t -butyl 3-oxopent-4-enoate 3 followed by treatment with trifluoroacetic acid yielded the alkaloid Δ 7 -mesembrenone 1 and its N-benzyl analogue 10 . These compounds are intermediates in formal
Publikováno v:
Tetrahedron Letters. 33:4751-4754
The title compounds were prepared by variations of a route in which the principal stages include conversion of N-substituted pyrrolidine-2-thiones 6 into vinylogous urethanes 10 , which undergo subsequent cycloacylation. A related approach that uses
Publikováno v:
Tetrahedron Letters. 33:6023-6024
Condensation of 3-arylated Δ 1 -pyrrolinium salts with t -butyl 3-oxopent-4-enoate 3 followed by treatment with trifluoroacetic acid yielded the alkaloid Δ 7 -mesembrenone 1 and its N-benzyl analogue 10 . These compounds are intermediates in formal
Publikováno v:
Tetrahedron. 45:1801-1814
Some studies are reported on the preparation of a new class of substituted 5-(2-pyridinyl)pyrimidines, starting with cyano(2-pyridinyl)ketenedithioacetal. This has been reacted with amidines under base-catalysed conditions, giving a variety of differ
Publikováno v:
Tetrahedron. 40:2879-2884
The alkaloids (±)-hygrine, (±)-dehydrodarlinine, (±)-dehydrodarlingianine, and (±)-N-methylruspolinone have been synthesised by selective reduction of vinylogous amides formed by sulphide contraction of the salts prepared by reaction of N-methyl-