Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruth Appanah"'
Publikováno v:
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3' of the transcription start site (TSS) region. CpGs 3' of the TSS of actively transcr
Externí odkaz:
https://doaj.org/article/b627f06793954db0abec4926ac76183a
Autor:
Dixie L. Mager, Kevin Dong, Danny Leung, Makoto Tachibana, Matthew C. Lorincz, Ruth Appanah, Yoichi Shinkai, Fabio M.V. Rossi, Preeti Goyal, Bernhard Lehnertz, Irina A. Maksakova, Sandra Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 108:5718-5723
Methylation on lysine 9 of histone H3 (H3K9me) and DNA methylation play important roles in the transcriptional silencing of specific genes and repetitive elements. Both marks are detected on class I and II endogenous retroviruses (ERVs) in murine emb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404389e391e3c5be5f2477d6ab40567f
https://doi.org/10.1073/pnas.1014660108
https://doi.org/10.1073/pnas.1014660108
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
Autor:
Makoto Tachibana, Yoichi Shinkai, Dixie L. Mager, Hao W Yang, Irina A. Maksakova, Lucia L. Lam, Dirk Schübeler, Ruth Appanah, Fabio Mohn, Kevin Dong, Danny Leung, Matthew C. Lorincz, Sandra Lee
Publikováno v:
The EMBO Journal. 27:2691-2701
Histone H3K9 methylation is required for DNA methylation and silencing of repetitive elements in plants and filamentous fungi. In mammalian cells however, deletion of the H3K9 histone methyltransferases (HMTases) Suv39h1 and Suv39h2 does not affect D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f111db0d2fb48efec0031c873fedfaa9
https://doi.org/10.1038/emboj.2008.193
https://doi.org/10.1038/emboj.2008.193
Autor:
Miguel Casanova, Haruhiko Koseki, Raymond A. Poot, Ruth Appanah, Tanja S. Preissner, Xiangzhi Li, Karel Bezstarosti, Andrea Cerase, Daisuke Yamada, Neil Brockdorff, Jeroen Demmers
Publikováno v:
Development, 138(8), 1471-1482. Company of Biologists Ltd
Polycomb group (PcG) proteins play an important role in the control of developmental gene expression in higher organisms. In mammalian systems, PcG proteins participate in the control of pluripotency, cell fate, cell cycle regulation, X chromosome in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6ef067d88850c7f30d5f0486e770ac
https://pure.eur.nl/en/publications/43e290b0-c626-4aa3-81ae-601d35536ca9
https://pure.eur.nl/en/publications/43e290b0-c626-4aa3-81ae-601d35536ca9
Publikováno v:
Epigenetics. 4(6)
Polycomb-mediated gene silencing and DNA methylation underlie many epigenetic processes important in normal development as well as in cancer. An interaction between EZH2 of the Polycomb repressive complex 2 (PRC2), which trimethylates lysine 27 on Hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cf8383be75a391f231ab4bf0c23020
https://pubmed.ncbi.nlm.nih.gov/19717977
https://pubmed.ncbi.nlm.nih.gov/19717977
Autor:
Neil Brockdorff, Rika Wakao, Haruhiko Koseki, Miguel Vidal, Jacqueline E. Mermoud, Y. Amy Tang, Arie P. Otte, Ruth Appanah, Mitusuhiro Endoh, Mariana de Napoles, Tatyana B. Nesterova, José C. R. Silva
Publikováno v:
Developmental Cell, 7, 663-676. Cell Press
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
In many higher organisms, 5%-15% of histone H2A is ubiquitylated at lysine 119 (uH2A). The function of this modification and the factors involved in its establishment, however, are unknown. Here we demonstrate that uH2A occurs on the inactive X chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deb9f2a87625590f6cdcc66ac31243d
https://dare.uva.nl/personal/pure/en/publications/polycomb-group-proteins-ring1ab-link-ubiquitylation-of-histone-h2a-to-heritable-gene-silencing-and-x-inactivation(687e2dca-4213-4581-aedf-2fe1a85ac451).html
https://dare.uva.nl/personal/pure/en/publications/polycomb-group-proteins-ring1ab-link-ubiquitylation-of-histone-h2a-to-heritable-gene-silencing-and-x-inactivation(687e2dca-4213-4581-aedf-2fe1a85ac451).html
Autor:
Maria Alexiou, Ruth Appanah, Alistair E. T. Newall, Colette M. Johnston, Neil Brockdorff, Jonathan Godwin, Tatyana B. Nesterova
The X-inactive-specific transcript (Xist) locus is acis-acting switch that regulates X chromosome inactivation in mammals. Over recent years an important goal has been to understand howXistis regulated at the initiation of X inactivation. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e9e40af5b6d77eda2fa8b7b857e768
https://europepmc.org/articles/PMC196458/
https://europepmc.org/articles/PMC196458/
Autor:
Neil Brockdorff, Winifred Mak, Zoe Webster, Ilona Zvetkova, José C. R. Silva, Tatyana B. Nesterova, Thomas Jenuwein, Arie P. Otte, Ruth Appanah, Antoine H.F.M. Peters
Publikováno v:
Developmental Cell, 4, 481-495. Cell Press
Previous studies have implicated the Eed-Enx1 Polycomb group complex in the maintenance of imprinted X inactivation in the trophectoderm lineage in mouse. Here we show that recruitment of Eed-Enx1 to the inactive X chromosome (Xi) also occurs in rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dc7eb44bdf51659a7f607fc7a19e5f
https://dare.uva.nl/personal/pure/en/publications/establishment-of-histone-h3-methylation-on-the-inactive-x-chromosome-requires-transient-recruitment-of-eedenx1-polycombgroup-complexes(6c7bf3fe-39ac-466a-9aa7-331bcf5f22a7).html
https://dare.uva.nl/personal/pure/en/publications/establishment-of-histone-h3-methylation-on-the-inactive-x-chromosome-requires-transient-recruitment-of-eedenx1-polycombgroup-complexes(6c7bf3fe-39ac-466a-9aa7-331bcf5f22a7).html
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3′ of the transcription start site (TSS) region. CpGs 3′ of the TSS of actively tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92591647206807f787e856d402e08045
https://doi.org/10.1371/journal.pgen.0030027.eor
https://doi.org/10.1371/journal.pgen.0030027.eor