Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ruth A. Schwalbe"'
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 3, Pp 519-538 (2024)
Aberrant N-glycosylation has been associated with progression of the pediatric cancer neuroblastoma (NB) but remains understudied. Here we investigated oligomannose N-glycans in NB by genetic editing of MGAT1 in a human NB cell line, BE(2)-C, called
Externí odkaz:
https://doaj.org/article/b6c5de65dfa54900bd2d7f1d3f027b91
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9165-9180 (2023)
A lack of complex and hybrid types of N-glycans in mice is embryonically lethal due to neural tube maldevelopment. N-acetylglucosaminyltransferase-I (GnT-I; Mgat1) catalyzes a required step for converting oligomannose N-glycans into hybrid and comple
Externí odkaz:
https://doaj.org/article/894f12d966204efe8827804e02a4400e
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 3, p 21 (2024)
The attachment of sugar to proteins and lipids is a basic modification needed for organismal survival, and perturbations in glycosylation cause severe developmental and neurological difficulties. Here, we investigated the neurological consequences of
Externí odkaz:
https://doaj.org/article/feeab5317247405bb36ce246c79d6ca2
Autor:
M. Kristen Hall, Asif Shajahan, Adam P. Burch, Cody J. Hatchett, Parastoo Azadi, Ruth A. Schwalbe
Publikováno v:
Biology, Vol 12, Iss 2, p 293 (2023)
Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans. Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using r
Externí odkaz:
https://doaj.org/article/1782f9e5ec274750aed8f1430b82f725
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Tumor development can be promoted/suppressed by certain N-glycans attached to proteins at the cell surface. Here we examined aberrant neuronal properties in 2D and 3D rat neuroblastoma (NB) cell cultures with different N-glycan populations. Lectin bi
Externí odkaz:
https://doaj.org/article/3b68945195b64f45a61ef8c9083e95be
Autor:
Fadi A. Issa, M. Kristen Hall, Cody J. Hatchett, Douglas A. Weidner, Alexandria C. Fiorenza, Ruth A. Schwalbe
Publikováno v:
Biology, Vol 10, Iss 6, p 486 (2021)
Neurological difficulties commonly accompany individuals suffering from congenital disorders of glycosylation, resulting from defects in the N-glycosylation pathway. Vacant N-glycosylation sites (N220 and N229) of Kv3, voltage-gated K+ channels of hi
Externí odkaz:
https://doaj.org/article/0f86af45fb914f81b2dd9c54d8c059eb
Publikováno v:
Biology, Vol 9, Iss 4, p 71 (2020)
Neuroblastoma (NB) development and progression are accompanied by changes in N-glycans attached to proteins. Here, we investigated the role of N-acetylglucosaminyltransferase-II (GnTII, MGAT2) protein substrates in neuroblastoma (NB) cells. MGAT2 was
Externí odkaz:
https://doaj.org/article/9cfbce92383242c1b6eb6584fae589b7
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 892-897 (2014)
E-cadherin is crucial for adhesion of cells to each other and thereby development and maintenance of tissue. While it is has been established that N-glycans inside the cell impact the level of E-cadherin at the cell surface of epithelial-derived cell
Externí odkaz:
https://doaj.org/article/8d61a2325b504fea85c27d68ae1aaaba
Autor:
M. Kristen Hall, Douglas A. Weidner, Yong Zhu, Sahil Dayal, Austin A. Whitman, Ruth A. Schwalbe
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 6, p 925 (2016)
Glycosylation modulates growth, maintenance, and stress signaling processes. Consequently, altered N-glycosylation is associated with reduced fitness and disease. Therefore, expanding our understanding of N-glycans in altering biological processes is
Externí odkaz:
https://doaj.org/article/c152e146ca8c4a42b308c42bb2e870f3
Autor:
Douglas A. Weidner, Cody J Hatchett, Ruth A. Schwalbe, M. Kristen Hall, Alexandria C Fiorenza, Fadi A. Issa
Publikováno v:
Biology, Vol 10, Iss 486, p 486 (2021)
Biology
Volume 10
Issue 6
Biology
Volume 10
Issue 6
Simple Summary Modifications in the repertoire of N-glycans at the cell surface are associated with neurological complications. However, knowledge of specific N-glycans as to their impact on neuronal excitability is lacking. Our proposed studies will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc11b8dbc705644da7f5b8bebd93950d
https://www.mdpi.com/2079-7737/10/6/486
https://www.mdpi.com/2079-7737/10/6/486