Zobrazeno 1 - 10
of 361
pro vyhledávání: '"Ruth A. Palmer"'
Autor:
Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ganesh Umapathy, Patricia Mendoza-Garcia, Tafheem Masudi, Andreas Schlosser, Dick R Nässel, Christian Wegener, Margret Shirinian, Ruth H Palmer
Publikováno v:
eLife, Vol 12 (2024)
Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila, including functions in the central nervous system (CNS), however the molecular details are poorly understood. To gain mechanistic insight, we employed Targeted Dam
Externí odkaz:
https://doaj.org/article/dfd88ed48fda4c0e92b123d709909f88
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
ObjectiveTo assess the influence of F1174S mutation on kinase activity and drug sensitivity of the echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) fusion (EML4-ALK) variants 1 and 3.MethodsWe constructed m
Externí odkaz:
https://doaj.org/article/f27d5081fd65467088ea119cc29cade6
Autor:
Joanna Szydzik, Dan E. Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy, Joachim Tetteh Siaw, Arne Claeys, Jonatan L. Gabre, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibit
Externí odkaz:
https://doaj.org/article/06e9a92a8a164615981fa91b32e6d409
Autor:
Arman Romiani, Johan Spetz, Emman Shubbar, Dan E. Lind, Bengt Hallberg, Ruth H. Palmer, Eva Forssell-Aronsson
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Neuroblastoma (NB) is one of the most frequently diagnosed tumors in infants. NB is a neuroendocrine tumor type with various characteristics and features, and with diverse outcome. The most malignant NBs have a 5-year survival rat
Externí odkaz:
https://doaj.org/article/f32ab4ad67f542fb86538f920f39e8ef
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Autor:
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/C
Externí odkaz:
https://doaj.org/article/07bf718e76ba44b88c1bdc5f2a42c7cc
Autor:
Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N. Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M. Yeung, Wenchao Wang, Bengt Hallberg, Ruth H. Palmer, Meredith S. Irwin, Rani E. George
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109363- (2021)
Summary: Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclea
Externí odkaz:
https://doaj.org/article/4d42e574c9364bf5b62295a7b9c9fc0b
Autor:
Joachim Tetteh Siaw, Niloufar Javanmardi, Jimmy Van den Eynden, Dan Emil Lind, Susanne Fransson, Angela Martinez-Monleon, Anna Djos, Rose-Marie Sjöberg, Malin Östensson, Helena Carén, Gunhild Trøen, Klaus Beiske, Ana P. Berbegall, Rosa Noguera, Wei-Yun Lai, Per Kogner, Ruth H. Palmer, Bengt Hallberg, Tommy Martinsson
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108171- (2020)
Summary: High-risk neuroblastomas typically display an undifferentiated or poorly differentiated morphology. It is therefore vital to understand molecular mechanisms that block the differentiation process. We identify an important role for oncogenic
Externí odkaz:
https://doaj.org/article/01191b05e5974287a9be5d2989de4d0a
Autor:
Muhammad Wasi Alam, Marcus Borenäs, Dan E. Lind, Diana Cervantes-Madrid, Ganesh Umapathy, Ruth H. Palmer, Bengt Hallberg
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Oncogenic receptor tyrosine kinases including anaplastic lymphoma kinase (ALK) are implicated in numerous solid and hematologic cancers. ALK mutations are reported in an estimated 9% of neuroblastoma and recent reports indicate that the percentage of
Externí odkaz:
https://doaj.org/article/7faf8d3a4d8d4609a56517ec10e415e2
Autor:
Bengt Hallberg, Ruth H. Palmer, Kristina Ruuth, Joel Weinmar, Christina Schönherr, Sattu Kamaraj, Per Kogner, Magnus Hansson, Helena Caren, Jonas Abrahamsson, Therese Eriksson, Tommy Martinsson
Supplementary Figure Legend from Appearance of the Novel Activating F1174S ALK Mutation in Neuroblastoma Correlates with Aggressive Tumor Progression and Unresponsiveness to Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d88518673d367946424c79fada0e8e
https://doi.org/10.1158/0008-5472.22388453
https://doi.org/10.1158/0008-5472.22388453
Autor:
Tzu-Po Chuang, Wei-Yun Lai, Jonatan L. Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik A. Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik B. Thorén, Anh Le, Robert Doebele, Jimmy V. Eynden, Ruth H. Palmer, Bengt Hallberg
Publikováno v:
Cancer Research. 83:3936-3936
Anaplastic lymphoma kinase (ALK) fusion variants in non-small-cell-lung cancer (NSCLC) consist of numerous dimerising fusion partners, with the most common being EML4. Clinical data suggests that the degree of treatment benefit in response to ALK tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f61d65609073b4450197b2047f246712
https://doi.org/10.1158/1538-7445.am2023-3936
https://doi.org/10.1158/1538-7445.am2023-3936