Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ruth A. Nelson"'
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Eseosa T. Ighodaro, Ryan K. Shahidehpour, Adam D. Bachstetter, Erin L. Abner, Ruth S. Nelson, David W. Fardo, Andy Y. Shih, Roger I. Grant, Janna H. Neltner, Frederick A. Schmitt, Gregory A. Jicha, Richard J. Kryscio, Donna M. Wilcock, Linda J. Van Eldik, Peter T. Nelson
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Littl
Externí odkaz:
https://doaj.org/article/1b7a8921bec849f2afb0d08e63ee89b6
Autor:
Ruth S. Nelson, Erin L. Abner, Gregory A. Jicha, Frederick A. Schmitt, Jing Di, Donna M. Wilcock, Justin M. Barber, Linda J. Van Eldik, Yuriko Katsumata, David W. Fardo, Peter T. Nelson
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) commonly impair quality of life and complicate clinical management. To in
Externí odkaz:
https://doaj.org/article/f20b21f32736429c942d8f87267f61a3
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurodegenerative diseases (NDs) involve complex cellular mechanisms that are incompletely understood. Emerging findings have revealed that disruption of nuclear processes play key roles in ND pathogenesis. The nucleus is a nexus for gene regulation
Externí odkaz:
https://doaj.org/article/f9b87151c54840bcb3170e5190246c97
Autor:
Jing Di, Ruth S. Nelson, Gregory A. Jicha, Daniela C. Moga, Justin M. Barber, Matthew D. Cykowski, David W. Fardo, Erin L. Abner, Peter T. Nelson
Publikováno v:
Journal of Alzheimer's Disease. :1-14
Background: Dementia and urinary incontinence (UI) are etiologically complex clinical syndromes. Dementia and UI often occur in the same individuals, but underlying factors connecting them are incompletely understood. Objective: Query data from a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12048e8b85e23f4a6592d8b9601488d9
https://doi.org/10.3233/jad-230425
https://doi.org/10.3233/jad-230425
Autor:
Prateek Kumar, Annie M Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew JM Rowan, Srikant Rangaraju
Publikováno v:
bioRxiv
SUMMARYOne of the earliest pathophysiological perturbations in Alzheimer’s Disease (AD) may arise from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early protein-level (proteomic) alterations in PV-INs can provide ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4db287bc6dc0263bd47a9668a705669
https://europepmc.org/articles/PMC10245729/
https://europepmc.org/articles/PMC10245729/
Autor:
Ruth Joan Nelson
Publikováno v:
Applied Mobilities. 8:1-25
With the adoption of the Sustainable Development Goals (SDGs) by the United Nations in 2015, aspirations towards creating more inclusive and sustainable cities became global standards of urban deve...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de1dfa08cb35f01ce03aead114efdb4
https://doi.org/10.1080/23800127.2021.1926054
https://doi.org/10.1080/23800127.2021.1926054
Autor:
Peter T. Nelson, Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, Maria M. Corrada, Matthew D. Cykowski, Jing Di, Dennis W. Dickson, Brittany N. Dugger, John F. Ervin, Jane Fleming, Jonathan Graff-Radford, Lea T. Grinberg, Suvi R. K. Hokkanen, Sally Hunter, Alifiya Kapasi, Claudia H. Kawas, Hannah A. D. Keage, C. Dirk Keene, Mia Kero, David S. Knopman, Naomi Kouri, Gabor G. Kovacs, Sydney A. Labuzan, Eric B. Larson, Caitlin S. Latimer, Renata E. P. Leite, Billie J. Matchett, Fiona E. Matthews, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Ruth S. Nelson, Janna H. Neltner, Aivi T. Nguyen, Ronald C. Petersen, Tuomo Polvikoski, R. Ross Reichard, Roberta D. Rodriguez, Claudia K. Suemoto, Shih-Hsiu J. Wang, Stephen B. Wharton, Lon White, Julie A. Schneider
Publikováno v:
Acta Neuropathol
Refereed/Peer-reviewed Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42264cbdfa96a5dbcbf8bf7cc96f45dd
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature communications. 13(1)
Proteomic profiling of brain cell types using isolation-based strategies pose limitations in resolving cellular phenotypes representative of their native state. We describe a mouse line for cell type-specific expression of biotin ligase TurboID, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eebd143366b3db5aac58a2b7c48f655
https://pubmed.ncbi.nlm.nih.gov/35614064
https://pubmed.ncbi.nlm.nih.gov/35614064