Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ruth A. Bodner"'
Autor:
Paolo Paganetti, Etienne Régulier, David E. Housman, Vanita Chopra, Ruth A. Bodner, Dorothee Abramowski, Graeme Bilbe, Scott Zeitlin, Corinna Klein, Jonathan H. Fox, Kimberly B. Kegel, Marian DiFiglia, Andreas Weiss, Steven M. Hersch, Muriel Stefani, Stephan Grueninger, H. Diana Rosas, Miriam Bibel
Publikováno v:
Analytical Biochemistry. 395:8-15
The genetic mutation causing Huntington's disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by formation of toxic intracellular fragments, aggregates, and cell death. Despite a clear pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08369eb70968506288e76576063e5069
https://doi.org/10.1016/j.ab.2009.08.001
https://doi.org/10.1016/j.ab.2009.08.001
Autor:
Ruth A. Bodner, Dorothee Bleckmann, Shanie Coven‐Easter, David E. Housman, Paolo Paganetti, Ina Hammerl, Christian N. Parker, Andreas Weiss, Monique Trapp
Publikováno v:
Chembiochem : a European journal of chemical biology. 10(10)
The quantification of cellular proteins is essential for the study of many different biological processes. This study describes an assay for the detection of the intracellular mutant huntingtin, the causative agent of Huntington's disease, with a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1facf995e3cc4b90b2f22bf553ea34eb
https://pubmed.ncbi.nlm.nih.gov/19492395
https://pubmed.ncbi.nlm.nih.gov/19492395
Publikováno v:
Cell cycle (Georgetown, Tex.). 5(14)
Neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's diseases are marked by neuronal accumulation of toxic misfolded protein. Developing therapies for these misfolding diseases requires finding chemical compounds that can eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcfbee65014c89156abeb4f170519eb
https://pubmed.ncbi.nlm.nih.gov/16861893
https://pubmed.ncbi.nlm.nih.gov/16861893
Autor:
Bradley T. Hyman, Ruth A. Bodner, Aleksey G. Kazantsev, Stephanie H. Cho, Stephen M. Altmann, Pamela J. McLean, Tiago F. Outeiro, David E. Housman, Michele M. Maxwell, Anne B. Young
Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington’s disease and α-synuclein in Parkinson’s disease. The disease-causing proteins can take various conformations and are prone to aggregate and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a282b17bb95579a766095283fb6ded27
https://europepmc.org/articles/PMC1449678/
https://europepmc.org/articles/PMC1449678/
