Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Ruth A. Roberts"'
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9–12 years who presented multiple putative antecedents of schizophre
Externí odkaz:
https://doaj.org/article/15ca3f48098e4a1d97ce531fed937d97
Autor:
Jane Barber, Ruth A. Roberts, Jean-Pierre Valentin, Delphine Baud, Claire Sadler, Phumzile Sikakana
Publikováno v:
Toxicol Res (Camb)
The aspartic proteases plasmepsin IX/X are important antimalarial drug targets due to their specificity to the malaria parasite and their vital role as mediators of disease progression. Focusing on parasite-specific targets where no human homologue e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9eb55b2c764d7a95f9f39a4bbecde3
https://doi.org/10.1093/toxres/tfaa106
https://doi.org/10.1093/toxres/tfaa106
Publikováno v:
Toxicology Research
Toxicity studies using mammalian species are generally required to provide safety data to support clinical development and licencing registration for potential new pharmaceuticals. International regulatory guidelines outline recommendations for the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b9b7ff56dd586ef198f802d104099f
https://doi.org/10.1093/toxres/tfaa081
https://doi.org/10.1093/toxres/tfaa081
Autor:
Calvert Louden, Ruth A. Roberts
Publikováno v:
Biomarkers in Drug Discovery and Development. :379-388
There is a compelling need for in vitro toxicity biomarkers for clinical endpoints. Toxicity biomarkers in the in vitro context are defined as quantitative measurable characteristics that serve as indicators of a pathologic process or related biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5c9b88dd45aee191afadffd13f9b30
https://doi.org/10.1002/9781119187547.ch19
https://doi.org/10.1002/9781119187547.ch19
Autor:
Petra C Gronholm, Tamsin Ford, Ruth E Roberts, Graham Thornicroft, Kristin R Laurens, Sara Evans-Lacko
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120004 (2015)
Many children and adolescents experiencing mental health problems do not receive appropriate care. Strategies to encourage appropriate access to services might be improved by a more detailed understanding of service use determinants within this group
Externí odkaz:
https://doaj.org/article/96b7b00fe0914cbc9d7c9f2e0f0b1f00
Publikováno v:
Drug Discovery Today
The discovery and development of new medicines is expensive, time-consuming, and often inefficient, with many failures along the way. Powered by artificial intelligence (AI), language models (LMs) have changed the landscape of natural language proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7078c424344c0299f90c53d8dd585a5
https://pubmed.ncbi.nlm.nih.gov/34216835
https://pubmed.ncbi.nlm.nih.gov/34216835
Autor:
Phumzile Sikakana, Ruth A. Roberts
Publikováno v:
Toxicol Res (Camb)
Here we look at popular trends and concepts in toxicology over the decade 2009–2019. The top 10 concepts included methodological approaches such as zebrafish and genomics as well as broader concepts such as personalized medicine and adverse outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c4a21d5c26be45130915cca7298abf
https://pubmed.ncbi.nlm.nih.gov/33178428
https://pubmed.ncbi.nlm.nih.gov/33178428
Publikováno v:
Chemical research in toxicology. 33(1)
In vitro toxicogenomics (TGx) has the potential to replace or supplement animal studies. However, TGx studies often suffer from a limited sample size and cell types. Meanwhile, transcriptomic data ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364cf2d58223851627bf030da0261783
https://pubmed.ncbi.nlm.nih.gov/31808688
https://pubmed.ncbi.nlm.nih.gov/31808688
Publikováno v:
Toxicol Res (Camb)
Data show that toxicity to the central nervous system (CNS) is the most frequent cause of safety failures during the clinical phase of drug development. CNS endpoints such as seizure pose a safety risk to patients and volunteers and can lead to a los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddd6485e2a9f10a4e86eba5ff0fd473a
https://pubmed.ncbi.nlm.nih.gov/32206299
https://pubmed.ncbi.nlm.nih.gov/32206299
Publikováno v:
Aging and Disabilities: Seeking Common Ground ISBN: 9781315227634
Aging and Disabilities: Seeking Common Ground
Aging and Disabilities: Seeking Common Ground
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4605f10f71fc10515c77af200544f679
https://doi.org/10.4324/9781315227634-14
https://doi.org/10.4324/9781315227634-14
