Výsledky vyhledávání - "Ruth A Valero"

Akademický článek

Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.

Autor: Sara Sanz-Blasco, Ruth A Valero, Ignacio Rodríguez-Crespo, Carlos Villalobos, Lucía Núñez

Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2718 (2008)

Dysregulation of intracellular Ca(2+) homeostasis may underlie amyloid beta peptide (Abeta) toxicity in Alzheimer's Disease (AD) but the mechanism is unknown. In search for this mechanism we found that Abeta(1-42) oligomers, the assembly state correl

Externí odkaz: https://doaj.org/article/d6a97514b7a94da3b9b1b3bc7b8f6441

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Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs

Autor: Lucía Núñez, Miriam Hernández-Morales, Diego Sobradillo, Daniel Ubierna, Mary Pat Moyer, Eva Muñoz, Carlos Villalobos, Ruth A. Valero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
UVaDOC. Repositorio Documental de la Universidad de Valladolid
Oncotarget

Producción Científica
Tumor cells undergo a critical remodeling of intracellular Ca2+ homeostasis that contribute to important cancer hallmarks. Store-operated Ca2+ entry (SOCE), a Ca2+ entry pathway modulated by mitochondria, is dramatically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a1a24d5420693446790d21987c5a87
https://doi.org/10.18632/oncotarget.19430

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Protein palmitoylation and subcellular trafficking

Autor: Clara Aicart-Ramos, Ignacio Rodríguez-Crespo, Ruth A. Valero

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808(12):2981-2994

Protein S-palmitoylation, the covalent lipid modification of the side chain of Cys residues with the 16-carbon fatty acid palmitate, is the most common acylation of proteins in eukaryotic cells. This post-translational modification provides an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d90e49763fab075f267a0ca711a0be6

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DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor

Autor: María Flor García-Mayoral, Marta Bruix, Ignacio Rodríguez-Crespo, Péter Rapali, Javier Merino-Gracia, Ruth A. Valero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2015 FEBS. It has been suggested that DYNLT, a dynein light chain known to bind to various cellular and viral proteins, can function as a microtubule-cargo adaptor. Recent data showed that DYNLT links the small GTPase Rab3D to microtubules and, fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b97d6a3b0b732eec4d4805c2e464b5a
http://hdl.handle.net/10261/130620

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Cell proliferation depends on mitochondrial Ca2+uptake: inhibition by salicylate

Autor: Javier García-Sancho, Ruth A. Valero, Laura Senovilla, Sara Sanz-Blasco, Lucía Núñez, Carlos Villalobos

Publikováno v: The Journal of Physiology. 571:57-73

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx pathway involved in control of multiple cellular and physiological processes including cell proliferation. Recent evidence has shown that SOCE depends critically on mitochondrial sinking of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba780c0473e62f3304a509e714a0cba9
https://doi.org/10.1113/jphysiol.2005.100586

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Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca2+-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria*

Autor: Eva M. Munoz, Ariel Quintana, Markus Hoth, Ruth A. Valero, Lucía Núñez, Carlos Villalobos

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Digital.CSIC. Repositorio Institucional del CSIC

Producción Científica
Abnormal vascular smooth muscle cell (VSMC) proliferation contributes to occlusive and proliferative disorders of the vessel wall. Salicylate and other nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit VSMC proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acedfad5eedce4ba4e9608ea7cc03575
https://europepmc.org/articles/PMC3091227/

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Structural determinants allowing endolysosomal sorting and degradation of endosomal GTPases

Autor: Mónica Herrera, Dolores Pérez-Sala, Ruth A. Valero, Clara L. Oeste, Irene Ramos, Patricia Boya, Konstantinos Stamatakis

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Rapid control of protein degradation is usually achieved through the ubiquitin-proteasome pathway. We recently found that the short-lived GTPase RhoB is degraded in lysosomes. Moreover, the fusion of the RhoB C-terminal sequence CINCCKVL, containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fab3282e7b9e28b09a55c08d5ada46
https://pubmed.ncbi.nlm.nih.gov/20573066

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RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells

Autor: Maria T. Berciano, Hector G. Palmer, Mireia Duñach, María Jesús Larriba, Ruth A. Valero, Carlos Villalobos, Antonio García de Herreros, Alberto Muñoz, Miguel Lafarga, Paloma Ordóñez-Morán, Antonio Barbáchano

Publikováno v: Journal of Cell Biology. 2008 Nov 17;183(4):697-710
Digital.CSIC. Repositorio Institucional del CSIC
instname
The Journal of Cell Biology
UVaDOC. Repositorio Documental de la Universidad de Valladolid
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Producción Científica
The active vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9902b023805e2b4c72800efb19ce49c5
http://hdl.handle.net/10902/1260

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The role of mitochondrial potential in control of calcium signals involved in cell proliferation

Autor: Lucía Núñez, Ruth A. Valero, Laura Senovilla, Carlos Villalobos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Store-operated Ca2+ entry (SOCE), a Ca2+ influx pathway involved in cell proliferation, depends on mitochondrial Ca2+ uptake, a Ca2+ influx that is driven by the mitochondrial potential (ΔΨ). Whereas much attention has been paid to the Ca2+-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2b25f9e05b8b4c195c46d54533bf05
http://hdl.handle.net/10261/72871

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Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

Autor: Lucía Núñez, Carlos Villalobos, Sara Sanz-Blasco, Ignacio Rodríguez-Crespo, Ruth A. Valero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PLoS ONE, Vol 3, Iss 7, p e2718 (2008)
UVaDOC. Repositorio Documental de la Universidad de Valladolid

Producción Científica
Dysregulation of intracellular Ca2+ homeostasis may underlie amyloid β peptide (Aβ) toxicity in Alzheimer's Disease (AD) but the mechanism is unknown. In search for this mechanism we found that Aβ1–42 oligomers, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54e4a3e6c1af48a560230dff5eefa61
https://doi.org/10.1371/journal.pone.0002718

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