Zobrazeno 1 - 10
of 664
pro vyhledávání: '"Ruth A, Singer"'
Autor:
Divya Mohan, Carmel M McEniery, Marie Fisk, Joseph Cheriyan, Bruce E Miller, Ruth Tal-Singer, Michael I Polkey, Holly Pavey, Ian Wilkinson, Richard Casaburi
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Aim To determine whether serum testosterone levels predict hospitalised acute exacerbations of COPD (H-AECOPD), cardiovascular disease outcome, and mortality in people with COPD.Methods Separate analyses were carried out on two observational, multice
Externí odkaz:
https://doaj.org/article/33d8e01306ac458f957e1e754856cf05
Autor:
Matthew Moll, Brian D. Hobbs, Aravind Menon, Auyon J. Ghosh, Rachel K. Putman, Takuya Hino, Akinori Hata, Edwin K. Silverman, John Quackenbush, Peter J. Castaldi, Craig P. Hersh, Michael J. McGeachie, Don D. Sin, Ruth Tal-Singer, Mizuki Nishino, Hiroto Hatabu, Gary M. Hunninghake, Michael H. Cho
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Interstitial lung abnormalities (ILA) are radiologic findings that may progress to idiopathic pulmonary fibrosis (IPF). Blood gene expression profiles can predict IPF mortality, but whether these same genes associate with ILA and
Externí odkaz:
https://doaj.org/article/51223a4fadff458db042a84805083d53
Autor:
Ruth Tal-Singer PhD, Bruce E Miller PhD, Jean M Rommes PhD, Mark A Luttmann BS, Christophe Demaison PhD, M Bradley Drummond MD, Cara B Pasquale MPH
Publikováno v:
Journal of Patient Experience, Vol 10 (2023)
Patient-centric drug development is crucial to creating treatments that address unmet patient needs but is often ignored. The COPD Foundation's COPD360Net ® includes a multistakeholder approach for operationalizing patient-centric development of tre
Externí odkaz:
https://doaj.org/article/94bac05ec2e941a4bb1026bb469d5d9c
Autor:
Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1803-1817 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested t
Externí odkaz:
https://doaj.org/article/bf76ffb6e2b4400fa7635ccceb291578
Autor:
Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the ass
Externí odkaz:
https://doaj.org/article/4e44582e7f784171ad0cc7e5e1a33440
Autor:
Koirobi Haldar, Leena George, Zhang Wang, Vijay Mistry, Mohammadali Yavari Ramsheh, Robert C. Free, Catherine John, Nicola F. Reeve, Bruce E. Miller, Ruth Tal-Singer, Adam J. Webb, Anthony J. Brookes, Martin D. Tobin, Dave Singh, Gavin C. Donaldson, Jadwiga A. Wedzicha, James R. Brown, Michael R. Barer, Christopher E. Brightling
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Airway bacterial dysbiosis is a feature of chronic obstructive pulmonary disease (COPD). However, there is limited comparative data of the lung microbiome between healthy smokers, non-smokers and COPD. Methods We compared the 16S
Externí odkaz:
https://doaj.org/article/73014c336784438f822b8bbf3948c801
Autor:
Mike Lonergan, Alison J. Dicker, Megan L. Crichton, Holly R. Keir, Melissa K. Van Dyke, Hana Mullerova, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely st
Externí odkaz:
https://doaj.org/article/7f6b874d07b14579bce1f96c5d5f4a5c
Autor:
Sarah R. Rønnow, Lasse L. Langholm, Morten A. Karsdal, Tina Manon-Jensen, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo, Diana J. Leeming, Jannie M. B. Sand
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-6 (2020)
Abstract Background Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI collagen has been iden
Externí odkaz:
https://doaj.org/article/e432bd97f6824e32b4de4a568577bf44
Autor:
Aili L. Lazaar, Bruce E. Miller, Alison C. Donald, Thomas Keeley, Claire Ambery, John Russell, Henrik Watz, Ruth Tal-Singer, for 205724 Investigators
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung in preclinical and human models of neutrophilic airway inflammation. A previous study with danirixin, a r
Externí odkaz:
https://doaj.org/article/b1804735a385439d93d084143b971507
Autor:
Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko, Victor J. Thannickal, Hemant K. Tiwari, Craig P. Hersh, Peter J. Castaldi, Edwin K. Silverman, Merry-Lynn N. McDonald
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Introduction Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene ex
Externí odkaz:
https://doaj.org/article/8fe83349e7e14355b35989dbedb0784d