Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ruth, Pilkington"'
Autor:
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re
Externí odkaz:
https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6
Autor:
Javier Rodriguez, Ruth Pilkington, Amaya Garcia Munoz, Lan K. Nguyen, Nora Rauch, Susan Kennedy, Naser Monsefi, Ana Herrero, Cormac T. Taylor, Alex von Kriegsheim
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2745-2760 (2016)
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistr
Externí odkaz:
https://doaj.org/article/00ee3bfef4a149938e0c86349229f870
Autor:
Benedetta Turriziani, Amaya Garcia-Munoz, Ruth Pilkington, Cinzia Raso, Walter Kolch, Alexander von Kriegsheim
Publikováno v:
Biology, Vol 3, Iss 2, Pp 320-332 (2014)
With the advent of the “-omics” era, biological research has shifted from functionally analyzing single proteins to understanding how entire protein networks connect and adapt to environmental cues. Frequently, pathological processes are initiate
Externí odkaz:
https://doaj.org/article/b18e4cc2ae0e4a42b60c12eeb6494fbe
Publikováno v:
Educational Action Research. 29:191-205
This paper explores the processes and outcomes of an action research project, which utilised action learning sets to explore the experiences of a community of academics, who promote pedagogical enh...
Autor:
Max Kotlyar, Priyanka Pillai, Theodosia Charitou, David Matallanas, Victoria Wong, Cinzia Raso, Luis F. Iglesias-Martinez, Colm J. Ryan, Steven Shave, Carlos Herrera-Montavez, Nicola Horn, Ruth Pilkington, Christina Kiel, Layal Dernayka, Miriam A. Lynn, Igor Jurisica, Manuel Bernal-Llinares, Lisa Imrie, Nora Rauch, Franziska Klose, Owen J. Sansom, David J. Lynn, Sriganesh Srihari, Marius Ueffing, Karsten Boldt, Luis Serrano, James Breen, Aleksandar Krstic, Erik Fasterius, Igor Stagljar, Kenneth Bryan, Mohamed Ali Jarboui, Thierry LeBihan, Boris N. Kholodenko, Oleksii S. Rukhlenko, Jasna Curak, Susan Kennedy, Manfred Auer, Cristina Al-Khalili Szigyarto, Walter Kolch, Patrizia Cammareri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Kennedy, S A, Jarboui, M, Srihari, S, Raso, C, Bryan, K, Dernayka, L, Charitou, T, Bernal-llinares, M, Herrera-montavez, C, Krstic, A, Matallanas, D, Kotlyar, M, Jurisica, I, Curak, J, Wong, V, Stagljar, I, Lebihan, T, Imrie, L, Pillai, P, Lynn, M A, Fasterius, E, Al-khalili Szigyarto, C, Breen, J, Kiel, C, Serrano, L, Rauch, N, Rukhlenko, O, Kholodenko, B N, Iglesias-martinez, L F, Ryan, C J, Pilkington, R, Cammareri, P, Sansom, O, Shave, S, Auer, M, Horn, N, Klose, F, Ueffing, M, Boldt, K, Lynn, D J & Kolch, W 2020, ' Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14224-9
nature.com
Nature Communications
Kennedy, S A, Jarboui, M, Srihari, S, Raso, C, Bryan, K, Dernayka, L, Charitou, T, Bernal-llinares, M, Herrera-montavez, C, Krstic, A, Matallanas, D, Kotlyar, M, Jurisica, I, Curak, J, Wong, V, Stagljar, I, Lebihan, T, Imrie, L, Pillai, P, Lynn, M A, Fasterius, E, Al-khalili Szigyarto, C, Breen, J, Kiel, C, Serrano, L, Rauch, N, Rukhlenko, O, Kholodenko, B N, Iglesias-martinez, L F, Ryan, C J, Pilkington, R, Cammareri, P, Sansom, O, Shave, S, Auer, M, Horn, N, Klose, F, Ueffing, M, Boldt, K, Lynn, D J & Kolch, W 2020, ' Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14224-9
nature.com
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K
Publikováno v:
Articles
Electrochemical and micro-imaging analysis of a commercial graphite-composite material is presented following electro-oxidation with β-methylumbelliferone. Charge-transfer surface modification was observed for the graphite electrode, presumed to hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d1705ad18664cfdc7308145781ca5e
https://arrow.tudublin.ie/context/cenresart/article/1090/viewcontent/elan.201900184.pdf
https://arrow.tudublin.ie/context/cenresart/article/1090/viewcontent/elan.201900184.pdf
Autor:
Ruth Pilkington
Publikováno v:
International Journal for Academic Development. 24:47-60
In 2015, over 40% of UK higher education (HE) institutions employed oral assessment when assessing and awarding fellowship on HE Academy-accredited schemes using the UK Professional Standards Frame...
Autor:
Ruth Pilkington, Fiona Jean Dixon
Publikováno v:
Teaching in Higher Education. 22:437-450
Now more than ever the concept of excellence is a crucial concern for both teachers and colleges in post-compulsory education. The current climate of austerity and performativity coupled with the t...
Autor:
Susan A, Kennedy, Mohamed-Ali, Jarboui, Sriganesh, Srihari, Cinzia, Raso, Kenneth, Bryan, Layal, Dernayka, Theodosia, Charitou, Manuel, Bernal-Llinares, Carlos, Herrera-Montavez, Aleksandar, Krstic, David, Matallanas, Max, Kotlyar, Igor, Jurisica, Jasna, Curak, Victoria, Wong, Igor, Stagljar, Thierry, LeBihan, Lisa, Imrie, Priyanka, Pillai, Miriam A, Lynn, Erik, Fasterius, Cristina, Al-Khalili Szigyarto, James, Breen, Christina, Kiel, Luis, Serrano, Nora, Rauch, Oleksii, Rukhlenko, Boris N, Kholodenko, Luis F, Iglesias-Martinez, Colm J, Ryan, Ruth, Pilkington, Patrizia, Cammareri, Owen, Sansom, Steven, Shave, Manfred, Auer, Nicola, Horn, Franziska, Klose, Marius, Ueffing, Karsten, Boldt, David J, Lynn, Walter, Kolch
Publikováno v:
Nature Communications
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K
Autor:
Pablo G. Jambrina, Nora Rauch, Ruth Pilkington, Katja Rybakova, Lan K. Nguyen, Boris N. Kholodenko, Nicolae-Viorel Buchete, Walter Kolch, Edina Rosta
Publikováno v:
Angewandte Chemie (International Ed. in English)
Jambrina, P G, Rauch, N, Pilkington, R, Rybakova, K, Nguyen, L K, Kholodenko, B N, Buchete, N V, Kolch, W & Rosta, E 2016, ' Phosphorylation of RAF kinase dimers drives conformational changes that facilitate transactivation ', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 55, no. 3, pp. 983-986 . https://doi.org/10.1002/anie.201509272
Jambrina, P G, Rauch, N, Pilkington, R, Rybakova, K, Nguyen, L K, Kholodenko, B N, Buchete, N V, Kolch, W & Rosta, E 2016, ' Phosphorylation of RAF kinase dimers drives conformational changes that facilitate transactivation ', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 55, no. 3, pp. 983-986 . https://doi.org/10.1002/anie.201509272
RAF kinases are key players in the MAPK signaling pathway and are important targets for personalized cancer therapy. RAF dimerization is part of the physiological activation mechanism, together with phosphorylation, and is known to convey resistance