Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Autor: Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re�

Externí odkaz: https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6

On-Beads Digestion in Conjunction with Data-Dependent Mass Spectrometry: A Shortcut to Quantitative and Dynamic Interaction Proteomics

Autor: Benedetta Turriziani, Amaya Garcia-Munoz, Ruth Pilkington, Cinzia Raso, Walter Kolch, Alexander von Kriegsheim

Publikováno v: Biology, Vol 3, Iss 2, Pp 320-332 (2014)

With the advent of the “-omics” era, biological research has shifted from functionally analyzing single proteins to understanding how entire protein networks connect and adapt to environmental cues. Frequently, pathological processes are initiate

Externí odkaz: https://doaj.org/article/b18e4cc2ae0e4a42b60c12eeb6494fbe

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Autor: Max Kotlyar, Priyanka Pillai, Theodosia Charitou, David Matallanas, Victoria Wong, Cinzia Raso, Luis F. Iglesias-Martinez, Colm J. Ryan, Steven Shave, Carlos Herrera-Montavez, Nicola Horn, Ruth Pilkington, Christina Kiel, Layal Dernayka, Miriam A. Lynn, Igor Jurisica, Manuel Bernal-Llinares, Lisa Imrie, Nora Rauch, Franziska Klose, Owen J. Sansom, David J. Lynn, Sriganesh Srihari, Marius Ueffing, Karsten Boldt, Luis Serrano, James Breen, Aleksandar Krstic, Erik Fasterius, Igor Stagljar, Kenneth Bryan, Mohamed Ali Jarboui, Thierry LeBihan, Boris N. Kholodenko, Oleksii S. Rukhlenko, Jasna Curak, Susan Kennedy, Manfred Auer, Cristina Al-Khalili Szigyarto, Walter Kolch, Patrizia Cammareri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Kennedy, S A, Jarboui, M, Srihari, S, Raso, C, Bryan, K, Dernayka, L, Charitou, T, Bernal-llinares, M, Herrera-montavez, C, Krstic, A, Matallanas, D, Kotlyar, M, Jurisica, I, Curak, J, Wong, V, Stagljar, I, Lebihan, T, Imrie, L, Pillai, P, Lynn, M A, Fasterius, E, Al-khalili Szigyarto, C, Breen, J, Kiel, C, Serrano, L, Rauch, N, Rukhlenko, O, Kholodenko, B N, Iglesias-martinez, L F, Ryan, C J, Pilkington, R, Cammareri, P, Sansom, O, Shave, S, Auer, M, Horn, N, Klose, F, Ueffing, M, Boldt, K, Lynn, D J & Kolch, W 2020, ' Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14224-9
nature.com

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc319b683485723bed6ff60ef6bb1dac
http://link.springer.com/article/10.1038/s41467-019-14224-9

Investigating the use of ‘professional dialogues’ when assessing academic practice: revealing learning, managing process, and enabling judgements

Autor: Ruth Pilkington

Publikováno v: International Journal for Academic Development. 24:47-60

In 2015, over 40% of UK higher education (HE) institutions employed oral assessment when assessing and awarding fellowship on HE Academy-accredited schemes using the UK Professional Standards Frame...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a36a02a30890c83fcbac6b61a18d8096
https://doi.org/10.1080/1360144x.2018.1512496

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS

Autor: Susan A, Kennedy, Mohamed-Ali, Jarboui, Sriganesh, Srihari, Cinzia, Raso, Kenneth, Bryan, Layal, Dernayka, Theodosia, Charitou, Manuel, Bernal-Llinares, Carlos, Herrera-Montavez, Aleksandar, Krstic, David, Matallanas, Max, Kotlyar, Igor, Jurisica, Jasna, Curak, Victoria, Wong, Igor, Stagljar, Thierry, LeBihan, Lisa, Imrie, Priyanka, Pillai, Miriam A, Lynn, Erik, Fasterius, Cristina, Al-Khalili Szigyarto, James, Breen, Christina, Kiel, Luis, Serrano, Nora, Rauch, Oleksii, Rukhlenko, Boris N, Kholodenko, Luis F, Iglesias-Martinez, Colm J, Ryan, Ruth, Pilkington, Patrizia, Cammareri, Owen, Sansom, Steven, Shave, Manfred, Auer, Nicola, Horn, Franziska, Klose, Marius, Ueffing, Karsten, Boldt, David J, Lynn, Walter, Kolch

Publikováno v: Nature Communications

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4c4c124719b557c7e00a1b876ae91ba
https://pubmed.ncbi.nlm.nih.gov/31980649