Výsledky vyhledávání - "Ruth, Isserlin"

Akademický článek

Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer

Autor: Madonna R. Peter, Misha Bilenky, Alastair Davies, Ruth Isserlin, Gary D. Bader, Neil E. Fleshner, Martin Hirst, Amina Zoubeidi, Bharati Bapat

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Androgens are a major driver of prostate cancer (PCa) and continue to be a critical treatment target for advanced disease, which includes castration therapy and antiandrogens. However, resistance to these therapies leading to metastatic cast

Externí odkaz: https://doaj.org/article/8a0d4c3f1dab4fb8aab66b888d10d9ef

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Akademický článek

Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

Autor: Maria Abou Chakra, Ruth Isserlin, Thinh N Tran, Gary D Bader

Publikováno v: eLife, Vol 10 (2021)

Cell cycle duration changes dramatically during development, starting out fast to generate cells quickly and slowing down over time as the organism matures. The cell cycle can also act as a transcriptional filter to control the expression of long gen

Externí odkaz: https://doaj.org/article/94c58a5523a7488fb18bc1d4bc928c83

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Akademický článek

netDx: interpretable patient classification using integrated patient similarity networks

Autor: Shraddha Pai, Shirley Hui, Ruth Isserlin, Muhammad A Shah, Hussam Kaka, Gary D Bader

Publikováno v: Molecular Systems Biology, Vol 15, Iss 3, Pp 1-11 (2019)

Abstract Patient classification has widespread biomedical and clinical applications, including diagnosis, prognosis, and treatment response prediction. A clinically useful prediction algorithm should be accurate, generalizable, be able to integrate d

Externí odkaz: https://doaj.org/article/0309d2c4a4e24c699be79e46aa0bf371

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Akademický článek

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Autor: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat

Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-19 (2019)

Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androg

Externí odkaz: https://doaj.org/article/e6d4dc82c3a047528c0b7b4c702f08f0

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Akademický článek

netDx: Software for building interpretable patient classifiers by multi-'omic data integration using patient similarity networks [version 2; peer review: 2 approved]

Autor: Shraddha Pai, Philipp Weber, Ruth Isserlin, Hussam Kaka, Shirley Hui, Muhammad Ahmad Shah, Luca Giudice, Rosalba Giugno, Anne Krogh Nøhr, Jan Baumbach, Gary D. Bader

Publikováno v: F1000Research, Vol 9 (2021)

Patient classification based on clinical and genomic data will further the goal of precision medicine. Interpretability is of particular relevance for models based on genomic data, where sample sizes are relatively small (in the hundreds), increasing

Externí odkaz: https://doaj.org/article/bb8150438e25444db549391763589b1f

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Akademický článek

RCy3: Network biology using Cytoscape from within R [version 3; peer review: 3 approved]

Autor: Julia A. Gustavsen, Shraddha Pai, Ruth Isserlin, Barry Demchak, Alexander R. Pico

Publikováno v: F1000Research, Vol 8 (2019)

RCy3 is an R package in Bioconductor that communicates with Cytoscape via its REST API, providing access to the full feature set of Cytoscape from within the R programming environment. RCy3 has been redesigned to streamline its usage and future devel

Externí odkaz: https://doaj.org/article/ef7f48e306e744b082207f552f024fe9

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