Výsledky vyhledávání - "Ruth, Halaban"

Akademický článek

Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction

Autor: Xinxing Li, Tao Liu, Antonella Bacchiocchi, Mengxing Li, Wen Cheng, Tobias Wittkop, Fernando L Mendez, Yingyu Wang, Paul Tang, Qianqian Yao, Marcus W Bosenberg, Mario Sznol, Qin Yan, Malek Faham, Li Weng, Ruth Halaban, Hai Jin, Zhiqian Hu

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2188-2209 (2024)

Abstract While whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for detection of molecular residual disease (MRD), its performance is limited by WGS error rate. Here we introduce AccuScan, an efficient cfDNA WGS technolog

Externí odkaz: https://doaj.org/article/61e8893361234a0aaada760b5863e691

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Akademický článek

Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma

Autor: Ruth Halaban, Kelly Olino, James Clune, David L Rimm, Harriet M Kluger, Dijana Djureinovic, Wael Ibrahim, Raymond Baumann, Anjela Galan, David G Su, David A. Schoenfeld, Raysa Cabrejo, Sajid A Khan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background Desmoplastic melanoma (DM) is a rare melanoma subtype characterized by dense fibrous stroma, a propensity for local recurrence, and a high response rate to programmed cell death protein 1 (PD-1) blockade. Occult sentinel lymph node positiv

Externí odkaz: https://doaj.org/article/b18e1e486f094e92a9872149f4a497c4

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Akademický článek

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5

Autor: Yanran Chen, Haomiao Su, Jianing Zhao, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Zhentian Wang, Xiongwen Cao, Sarah A. Slavoff

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113145- (2023)

Summary: The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and outside the nucleus. However, it is currently unclear whether and how the distribution of WDR5 between complexes is regulated. Here, we show that an unan

Externí odkaz: https://doaj.org/article/677a2dd973a34f00ba7e7ac83d8ed9a4

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Akademický článek

Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Despite acral melanoma being the most common melanoma subtype in non-White individuals, its molecular drivers remain unknown. Here, the authors integrate genomic and clinical data from 104 patients and identify late-arising focal amplifications of ch

Externí odkaz: https://doaj.org/article/b66dfca16a5a4cbdb29e51d65dceaf25

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Akademický článek

Retrospective cell lineage reconstruction in humans by using short tandem repeats

Publikováno v: Cell Reports: Methods, Vol 1, Iss 3, Pp 100054- (2021)

Summary: Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals. In contrast, hu

Externí odkaz: https://doaj.org/article/ba8554237db044ec9dcf871c12171ac6

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