Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ruth, Eichner"'
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Akademický článek
B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation
Autor: Lisa Pfeuffer, Viola Siegert, Julia Frede, Leonie Rieger, Riccardo Trozzo, Niklas de Andrade Krätzig, Sandra Ring, Shamim Sarhadi, Nicole Beck, Stefan Niedermeier, Mar Abril-Gil, Mohamed Elbahloul, Marianne Remke, Katja Steiger, Ruth Eichner, Julia Jellusova, Roland Rad, Florian Bassermann, Christof Winter, Jürgen Ruland, Maike Buchner
Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model with active RANK signaling and the TCL1 oncogene, di
Externí odkaz: https://doaj.org/article/5d14702a54c246dbbd1aa8836923caa2
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2
Data from Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders
Autor: Philipp B. Staber, Berend Snijder, Giulio Superti-Furga, Ingrid Simonitsch-Klupp, Niklas Zojer, Christoph C. Zielinski, Dominik Wolf, Cora Waldstein, Stefan Vogt, Katrina Vanura, Emiel van der Kouwe, Peter Valent, Renate Thalhammer, Ismet Srndic, Wolfgang R. Sperr, Cathrin Skrabs, Christian Sillaber, Edgar Selzer, Ilse Schwarzinger, Ann-Sofie Schmolke, Ana-Iris Schiefer, Julius Salamon, Reinhard Ruckser, Robin Ristl, Markus Raderer, Gerald W. Prager, Edit Porpaczy, Alexander Pichler, Michael Panny, Leopold Öhler, Katharina Ocko, Thomas Noesslinger, Peter Neumeister, Leonhard Müllauer, Katsuhiro Miura, Olaf Merkel, Elisabeth Menschel, Marius E. Mayerhoefer, Simone Lubowitzki, Trang Le, Stefan Kubicek, Gerhard Krajnik, Nikolaus Krall, Barbara Kiesewetter, Lukas Kenner, Lukas Kazianka, Ulrich Jaeger, Georg Hopfinger, Mir Alireza Hoda, Daniel Heintel, Tim Heinemann, Alexander W. Hauswirth, Bernd Lorenz Hartmann, Marcus Hacker, Wolfgang Gstöttner, Hildegard T. Greinix, Klaus Geissler, Alexander Gaiger, Maurizio Forte, Verena Felsleitner-Hauer, Ruth Exner, Harald Esterbauer, Martin Erl, Ruth Eichner, Sandra Eder, Michael Bergmann, Günther Bayer, Gregory I. Vladimer, Tea Pemovska, Christoph Kornauth
Personalized medicine aims to match the right drug with the right patient by using specific features of the individual patient's tumor. However, current strategies of personalized therapy matching provide treatment opportunities for less than 10% of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9887042c05486a909c745cd96689d6c
https://doi.org/10.1158/2159-8290.c.6549464.v1
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3
Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders
Autor: Leopold Öhler, Philipp B. Staber, Julius Salamon, Edit Porpaczy, Gerhard Krajnik, Gregory I. Vladimer, Harald Esterbauer, Ulrich Jaeger, Christian Sillaber, Gerald W. Prager, Katrina Vanura, Stefan Kubicek, Peter Valent, Michael Panny, Alexander W. Hauswirth, Edgar Selzer, Verena Felsleitner-Hauer, Emiel van der Kouwe, Nikolaus Krall, Marius E. Mayerhoefer, Bernd Lorenz Hartmann, Alexander Gaiger, Sandra Eder, Klaus Geissler, Mir Alireza Hoda, Dominik Wolf, Simone Lubowitzki, Peter Neumeister, Barbara Kiesewetter, Ruth Exner, Giulio Superti-Furga, Thomas Noesslinger, Elisabeth Menschel, Katsuhiro Miura, Wolfgang Gstöttner, Reinhard Ruckser, Ingrid Simonitsch-Klupp, Hildegard Greinix, Ana-Iris Schiefer, Ann-Sofie Schmolke, Cora Waldstein, Georg Hopfinger, Christoph C. Zielinski, Wolfgang R. Sperr, Marcus Hacker, Trang Le, Robin Ristl, Christoph Kornauth, Lukas Kazianka, Tea Pemovska, Günther Bayer, Cathrin Skrabs, Markus Raderer, Ruth Eichner, Alexander Pichler, Lukas Kenner, Maurizio Forte, Renate Thalhammer, Stefan Vogt, Leonhard Müllauer, Katharina Ocko, Niklas Zojer, Berend Snijder, Ilse Schwarzinger, Olaf Merkel, Martin Erl, Daniel Heintel, Michael Bergmann, Tim Heinemann, Ismet Srndic
Publikováno v: Cancer Discovery, 12 (2)
Personalized medicine aims to match the right drug with the right patient by using specific features of the individual patient's tumor. However, current strategies of personalized therapy matching provide treatment opportunities for less than 10% of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ef6465faab2cb5917a550f8e3d5a11
https://doi.org/10.1158/2159-8290.cd-21-0538
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4
Treatment Guided By Next Generation Functional Drug Screening Provides Clinical Benefit in Advanced Aggressive Hematological Malignancies: Final Evaluation of the Open Label, Single Arm Exalt Trial
Autor: Tea Pemovska, Alexander Pichler, Leonhard Muellauer, Wolfgang R. Sperr, Trang Le, Ulrich Jaeger, Katrina Vanura, Christoph Kornauth, Nikolaus Krall, Giulio Superti-Furga, Renate Thalhammer, Peter Neumeister, Philipp B. Staber, Gregory I. Vladimer, Edit Porpaczy, Harald Esterbauer, Christoph C. Zielinski, Julius Salamon, Reinhard Ruckser, Katharina Ocko, Ilse Schwarzinger, Ruth Eichner, Markus Raderer, Ruth Exner, Michael Panny, Gerald W. Prager, Wolfgang Gstöttner, Verena Felsleitner-Hauer, Edgar Selzer, Lukas Kenner, Maurizio Forte, Marius E. Mayerhoefer, Ana-Iris Schiefer, Lukas Kazianka, Alexander Gaiger, Günther Bayer, Ann-Sofie Schmolke, Stefan Vogt, Cora Waldstein, Daniel Heintel, Berend Snijder, Marcus Hacker, Robin Ristl, Barbara Kiesewetter, Alexander W. Hauswirth, Mir Alireza Hoda, Katsuhiro Miura, Dominik Wolf, Ingrid Simonitsch-Klupp, Cathrin Skrabs, Emiel van der Kouwe, Simone Lubowitzki, Elisabeth Menschel, Peter Valent, Hildegard Greinix, Sandra Eder, Olaf Merkel, Leopold Öhler, Michael Bergmann, Tim Heinemann, Ismet Srndic, Thomas Noesslinger
Publikováno v: Blood. 136:2-4
Background: Aggressive hematological malignancies in relapsed/refractory setting bear a dire prognosis with low cure rates and short survival. Matching these patients to therapies is challenged by complexity due to spatial and temporal tumor evolutio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32a7e822d529f8a6431b5e5c93b1ebe2
https://doi.org/10.1182/blood-2020-140831
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6
Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma
Autor: Ruth, Eichner, Vanesa, Fernández-Sáiz, Bianca-Sabrina, Targosz, Florian, Bassermann
Publikováno v: International review of cell and molecular biology. 343
Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5-6years, thus necessit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5819767d318a700b4b0cf3e12ba251f
https://pubmed.ncbi.nlm.nih.gov/30712673
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7
Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma
Autor: Bianca-Sabrina Targosz, Florian Bassermann, Ruth Eichner, Vanesa Fernández-Sáiz
Publikováno v: International Review of Cell and Molecular Biology volume 343
International Review of Cell and Molecular Biology ISBN: 9780128167038
International Review of Cell and Molecular Biology
Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5–6 years, thus neces
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a8ac5bf4df0d367a21340b2c241db1
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8
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
Autor: Johannes W. Bigenzahn, Patrick Essletzbichler, Ismet Srndic, Felix Kartnig, Leonhard X. Heinz, Pavel Kovarik, Enrico Girardi, Ulrich Goldmann, Paula Nunes-Hasler, Vitaly Sedlyarov, Ruth Eichner, Manuele Rebsamen, Nicolas Demaurex, Anna Moskovskich, Giulio Superti-Furga
Publikováno v: Cell Host & Microbe, Vol. 23, No 6 (2018) pp. 766-774.e5
Cell Host & Microbe
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we identified the bicarbonate transporter SLC4A7, which is strongly induced upon macrophage differe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81e778b6dbcb9b24ade287bde0a27b3
https://archive-ouverte.unige.ch/unige:109624
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9
The ubiquitin proteasome system — Implications for cell cycle control and the targeted treatment of cancer
Autor: Ruth Eichner, Michele Pagano, Florian Bassermann
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843(1):150-162
Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins: the SCF (Skp1/Cul1/F-box protein) complex and the APC/C (anaphase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05827dff71b5aa6e8160dab43e93f4ae
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10
The IMiD-Target Cereblon Determines Transmembrane Protein Quality Control Promoting Tumor Metabolism
Autor: Vanesa Fernández-Sáiz, Ruth Eichner, Martina Rudelius, Florian Bassermann, Bernhard Kuster, Jannis Lawatscheck, Christian Peschel, Jacob Stroh, Michael Heider, Jana Zecha, Anne-Kathrin Garz, Anna Kuisl, Katharina Götze, Simone Lemeer, Johannes Buchner, Ulrich Keller
Publikováno v: Blood. 134:314-314
Introduction: Cereblon (CRBN) is the target for immunomodulatory drugs (IMiDs) such as thalidomide and its derivatives lenalidomide and pomalidomide, which are key therapeutics for hematologic malignancies such as multiple myeloma (MM) and del(5q) my
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4dee33dcf2959c848c3bdeb3e0325a6
https://doi.org/10.1182/blood-2019-129064
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