Gender, Variation in Opioid Receptor Genes and Sensitivity to Experimental Pain

Autor: Joanne Droney, Lars Arendt-Nielsen, Anne Estrup Olesen, Trine Andresen, Camilla Staahl, Hiroe Sato, Asbjørn Mohr Drewes, Ruth Branford, Joy Ross, Julia Riley

Publikováno v: Sato, H, Droney, J, Ross, J, Olesen, A E, Ståhl, C, Andresen, T, Branford, R, Riley, J, Arendt-Nielsen, L & Drewes, A 2013, ' Gender, variation in opioid receptor genes and sensitivity to experimental pain ', Molecular Pain, vol. 9, 20 . https://doi.org/10.1186/1744-8069-9-20
Molecular Pain

Background Pain tolerance is subject to considerable inter-individual variation, which may be influenced by a number of genetic and non-genetic factors. The mu, delta and kappa opioid receptors play a role in pain perception and are thought to mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1958a49ad8523bac9005dd5c2ed93cc3
https://doi.org/10.1186/1744-8069-9-20

Pharmacogenetics of analgesic drugs

Autor: Roman, Cregg, Giovanna, Russo, Anthony, Gubbay, Ruth, Branford, Hiroe, Sato

Publikováno v: British Journal of Pain

Summary points • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. • Analgesics act in various ways on the peripheral and central pain path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cd9762c1cba9d911c553d1788140e94
https://pubmed.ncbi.nlm.nih.gov/26516523

The Genetic Influences on Oxycodone Response Characteristics in Human Experimental Pain

Autor: Ruth Branford, Hiroe Sato, Joanne Droney, Lars Arendt-Nielsen, Asbjørn Mohr Drewes, Joy R Ross, Camilla Staahl, Lecia Møller Nielsen, S Gretton, Anne Estrup Olesen, Julia Riley

Publikováno v: Olesen, A E, Sato, H, Nielsen, L M, Staahl, C, Droney, J, Gretton, S, Branford, R, Drewes, A M, Arendt-Nielsen, L, Riley, J & Ross, J 2015, ' The Genetic Influences on Oxycodone Response Characteristics in Human Experimental Pain ', Fundamental and Clinical Pharmacology, vol. 49, no. 4, pp. 417-425 . https://doi.org/10.1111/fcp.12128

Human experimental pain studies are of value to study basic pain mechanisms under controlled conditions. The aim of this study was to investigate if genetic variation across selected mu-, kappa- and delta-opioid receptor genes (OPRM1, OPRK1and OPRD1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d420cf59887e8f5b9ea312a3429203
https://vbn.aau.dk/da/publications/42b266ef-09d0-4d91-a389-be52d4c301ac

Adverse event reporting in randomised controlled trials of neuropathic pain: Considerations for future practice

Autor: Janet L. Peacock, Paul Farquhar-Smith, Victoria Cornelius, John E Williams, Odile Sauzet, Joy R Ross, Salma Ayis, Ruth Branford

High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc164ba39a5c0ec0fe19fc7be4ea8292
https://pub.uni-bielefeld.de/record/2560121

Analgesia and central side-effects: two separate dimensions of morphine response

Autor: Joanne M, Droney, Sophy K, Gretton, Hiroe, Sato, Joy R, Ross, Ruth, Branford, Kenneth I, Welsh, William, Cookson, Julia, Riley

Publikováno v: British journal of clinical pharmacology. 75(5)

To present a statistical model for defining interindividual variation in response to morphine and to use this model in a preliminary hypothesis-generating multivariate genetic association study.Two hundred and sixty-four cancer patients taking oral m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a64d1cfdc47ed679f3847ed4acc614d8
https://pubmed.ncbi.nlm.nih.gov/23072578