Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Rutger W W Brouwer"'
Autor:
Iris S. C. Verploegh, Andrea Conidi, Hoesna El Hassnaoui, Floor A. M. Verhoeven, Anne L. Korporaal, Ioannis Ntafoulis, Mirjam C. G. N. van den Hout, Rutger W. W. Brouwer, Martine L. M. Lamfers, Wilfred F. J. van IJcken, Danny Huylebroeck, Sieger Leenstra
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10176 (2024)
One of the main causes of poor prognoses in patient with glioblastoma (GBM) is drug resistance to current standard treatment, which includes chemoradiation and adjuvant temozolomide (TMZ). In addition, the concept of cancer stem cells provides new in
Externí odkaz:
https://doaj.org/article/ec5a0fdd41ef4ee99baa731e0556a5e3
Autor:
Ellen Looijesteijn, Rutger W. W. Brouwer, Ruud J. W. Schoemaker, Laurien H. Ulfman, Stephanie L. Ham, Prescilla Jeurink, Eva Karaglani, Wilfred F. J. van IJcken, Yannis Manios
Publikováno v:
BMC Nutrition, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract Background Natural enrichment of sn-2 palmitate content of infant formulae by using bovine milk fat is known to reduce formation of faecal fatty acid soaps and to improve stool consistency, but effects on gut microbiota composition are unkno
Externí odkaz:
https://doaj.org/article/9aac1f119efc42dbaf40691e99aad2bf
Autor:
Karol Nowosad, Rutger W. W. Brouwer, Adrian Odrzywolski, Anne L. Korporaal, Bartłomiej Gielniewski, Bartosz Wojtaś, Wilfred F. J. van IJcken, Frank Grosveld, Danny Huylebroeck, Przemko Tylzanowski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The formation of the synovial joint begins with the visible emergence of a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen called the interzone. Recently the transcriptome of the earl
Externí odkaz:
https://doaj.org/article/1d1993d01b414e72859fe01102787e3e
Autor:
Job van Riet, Chinmoy Saha, Nikolaos Strepis, Rutger W. W. Brouwer, Elena S. Martens-Uzunova, Wesley S. van de Geer, Sigrid M. A. Swagemakers, Andrew Stubbs, Yassir Halimi, Sanne Voogd, Arif Mohammad Tanmoy, Malgorzata A. Komor, Youri Hoogstrate, Bart Janssen, Remond J. A. Fijneman, Yashar S. Niknafs, Arul M. Chinnaiyan, Wilfred F. J. van IJcken, Peter J. van der Spek, Guido Jenster, Rogier Louwen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
CRISPR elements in the human genome are expressed in both healthy tissues and tumors but with distinct patterns, representing a potential biomarker for cancer.
Externí odkaz:
https://doaj.org/article/f067cb604205407abac008b0006c1b2e
Autor:
Amy C. J. van der List, Nicolle H. R. Litjens, Rutger W. W. Brouwer, Mariska Klepper, Alexander T. den Dekker, Wilfred F. J. van Ijcken, Michiel G. H. Betjes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14463 (2023)
After kidney transplantation (KT), donor-specific hyporesponsiveness (DSH) of recipient T cells develops over time. Recently, apoptosis was identified as a possible underlying mechanism. In this study, both transcriptomic profiles and complete V(D)J
Externí odkaz:
https://doaj.org/article/519b06c15f8343308b91d50e14332303
Autor:
Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer, Xander T. den Dekker, Wilfred F. J. van IJcken, Benjamin Nota, Alex E. Felice, Thamar B. van Dijk, Marieke von Lindern, Joseph Borg, Emile van den Akker, Sjaak Philipsen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of β-hemoglobinopathies and downregulation of KLF1 activity
Externí odkaz:
https://doaj.org/article/c05d644c68534f3f9075683f486793e0
Autor:
Erwin Brosens, Nina C. J. Peters, Kim S. van Weelden, Charlotte Bendixen, Rutger W. W. Brouwer, Frank Sleutels, Hennie T. Bruggenwirth, Wilfred F. J. van Ijcken, Danielle C. M. Veenma, Suzan C. M. Cochius-Den Otter, Rene M. H. Wijnen, Alex J. Eggink, Marieke F. van Dooren, Heiko Martin Reutter, Robbert J. Rottier, J. Marco Schnater, Dick Tibboel, Annelies de Klein
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Congenital diaphragmatic hernia (CDH) is a congenital structural anomaly in which the diaphragm has not developed properly. It may occur either as an isolated anomaly or with additional anomalies. It is thought to be a multifactorial disease in which
Externí odkaz:
https://doaj.org/article/af7137285f524b758a0191a77d8686a3
Autor:
Nicolle H. R. Litjens, Anton W. Langerak, Amy C. J. van der List, Mariska Klepper, Maaike de Bie, Zakia Azmani, Alexander T. den Dekker, Rutger W. W. Brouwer, Michiel G. H. Betjes, Wilfred F. J. Van IJcken
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Transcriptomics can be combined with TRA and TRB clonotype analysis at the single cell level. The aim of this study was to validate this approach on the ICELL8 Single-Cell system and to evaluate its usefulness to analyse clinical paucicellular sample
Externí odkaz:
https://doaj.org/article/306135e5e78044de8362b0971dd85cf5
Autor:
Ashley van der Spek, Sophie C. Warner, Linda Broer, Christopher P. Nelson, Dina Vojinovic, Shahzad Ahmad, Pascal P. Arp, Rutger W. W. Brouwer, Matthew Denniff, Mirjam C. G. N. van den Hout, Jeroen G. J. van Rooij, Robert Kraaij, Wilfred F. J. van IJcken, Nilesh J. Samani, M. Arfan Ikram, André G. Uitterlinden, Veryan Codd, Najaf Amin, Cornelia M. van Duijn
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Telomeres are important for maintaining genomic stability. Telomere length has been associated with aging, disease, and mortality and is highly heritable (∼82%). In this study, we aimed to identify rare genetic variants associated with telomere len
Externí odkaz:
https://doaj.org/article/c77eae33646043f3bedc794e8a9da48a
Autor:
João Pereira, Lucas R. F. Bresser, Natal van Riel, Ellen Looijesteijn, Ruud Schoemaker, Laurien H. Ulfman, Prescilla Jeurink, Eva Karaglani, Yannis Manios, Rutger W. W. Brouwer, Wilfred F. J. van Ijcken, Evgeni Levin
Publikováno v:
BioMedInformatics; Volume 2; Issue 2; Pages: 281-296
The integration and analysis of multi-omics modalities is an important challenge in bioinformatics and data science in general. A standard approach is to conduct a series of univariate tests to determine the significance for each parameter, but this