Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Rutger Meinsma"'
1
Akademický článek
Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes
Autor: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen, Godelieve A. M. Tytgat
Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is caused by selective upt
Externí odkaz: https://doaj.org/article/e3482717233340d9b6a012d2838da30a
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2
Akademický článek
Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake
Autor: Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg, Godelieve A. M. Tytgat
Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via sele
Externí odkaz: https://doaj.org/article/0e95c18dbaee417495963f09c52009dc
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3
Akademický článek
The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.
Autor: Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters
Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162901 (2016)
Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors. RX-3117 is activated
Externí odkaz: https://doaj.org/article/ecd36541f4fd43e4b410765524e870bd
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4
β-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity
Autor: Doreen Dobritzsch, Judith Meijer, Rutger Meinsma, Dirk Maurer, Ardeshir A. Monavari, Anders Gummesson, Annika Reims, Jorge A. Cayuela, Natalia Kuklina, Jean-François Benoist, Laurence Perrin, Birgit Assmann, Georg F. Hoffmann, Jörgen Bierau, Angela M. Kaindl, André B.P. van Kuilenburg
Publikováno v: Molecular genetics and metabolism, 136(3), 177-185. Academic Press Inc.
Molecular Genetics and Metabolism, 136(3), 177-185. Academic Press
Molecular Genetics and Metabolism, 136(3), 177-185. Academic Press Inc.
beta-Ureidopropionase is the third enzyme of the pyrimidine degradation pathway and catalyses the conversion of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid to beta-alanine and beta-aminoisobutyric acid, ammonia and CO2. To date,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4548d2ad17ee7613703e5f517be70cb1
https://doi.org/10.1016/j.ymgme.2022.01.102
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5
Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma
Autor: Iedan R. N. Verly, Yvette A. H. Matser, René Leen, Rutger Meinsma, Marta Fiocco, Jan Koster, Richard Volckmann, Dilara Savci-Heijink, Giuliana Cangemi, Sebastiano Barco, Linda J. Valentijn, Godelieve A. M. Tytgat, André B. P. van Kuilenburg
Publikováno v: JCO Precision Oncology, 6. LIPPINCOTT WILLIAMS & WILKINS
JCO Precision Oncology, 6:e2000447. American Society of Clinical Oncology
PURPOSE Elevated urinary 3-methoxytyramine (3MT) level at diagnosis was recently put forward as independent risk factor for poor prognosis in neuroblastoma. Here, we investigated the biologic basis underlying the putative association between elevated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e0374dba51e3faacf8e291c8764558
https://doi.org/10.1200/po.20.00447
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6
Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes
Autor: Marten Hansen, André B.P. van Kuilenburg, Thomas Blom, Emile van den Akker, Rutger Meinsma, Franca di Summa, Godelieve A.M. Tytgat
Publikováno v: EJNMMI research, 11(1):81. Springer Berlin
EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021)
EJNMMI Research
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is caused by selective uptake of MI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dbe93a309e5ec8913fa7b2c4936d24
https://doi.org/10.1186/s13550-021-00823-5
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7
Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake
Autor: Rutger Meinsma, Marja Rutgers, Marieke Dekken-Van den Burg, Thomas Blom, Godelieve A.M. Tytgat, Corine K.M. Buitenhuis, André B.P. van Kuilenburg
Publikováno v: EJNMMI research, 10(1):78. Springer Berlin
EJNMMI Research
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via selective upt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcfbc144a08664293c72da9296916c5
https://pure.amc.nl/en/publications/selective-serotonin-reuptake-inhibitors-ssris-prevent-metaiodobenzylguanidine-mibg-uptake-in-platelets-without-affecting-neuroblastoma-tumor-uptake(e99bfeab-6f89-423c-aefe-d0cb19711392).html
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9
Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity
Autor: Rutger Meinsma, Tetsuya Ito, Yoriko Watanabe, Lida Zoetekouw, Jeroen Roelofsen, Yoko Nakajima, Judith Meijer, Doreen Dobritzsch, Chunhua Zhang, André B.P. van Kuilenburg, Kyoko Tashiro, Xu Wang
Publikováno v: Molecular genetics and metabolism, 122(4), 216-222. Academic Press Inc.
Dihydropyrimidinase (DHP) is the second enzyme of the pyrimidine degradation pathway and catalyzes the ring opening of 5,6-dihydrouracil and 5,6-dihydrothymine. To date, only 31 genetically confirmed patients with a DHP deficiency have been reported
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d81a4172f0904f90465595af5a28f07
https://doi.org/10.1016/j.ymgme.2017.10.003
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10
Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines
Autor: A. B. P. Van Kuilenburg, Rutger Meinsma
Publikováno v: Nucleosides, nucleotides & nucleic acids, 35(10-12), 613-618. Marcel Dekker Inc.
Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine, cytidine, and several pyrimidine ribonucleoside analogs. We overexpressed and purified the two known isoforms of human UCK in Escherichia coli, produced a specific antibody again
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca39c6851b511b0aafc562b707ed306
https://doi.org/10.1080/15257770.2015.1124998
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