Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Rutesh H. Dave"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1040 (2023)
Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, an
Externí odkaz:
https://doaj.org/article/ff31cbb4e7bb495f88c9712a9ebf3a21
Autor:
Joseph S. Saddik, Rutesh H. Dave
Publikováno v:
Powder Technology. 386:298-306
Tablet sticking, a phenomenon in which material adheres to the surface of tablet-punch face, is an ongoing and costly problem in pharmaceutical manufacturing, and is a significant issue for drug-product formulators. Here, it was hypothesized that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d388133ced4f94e68c8bf4aebb0a12c
https://doi.org/10.1016/j.powtec.2021.03.062
https://doi.org/10.1016/j.powtec.2021.03.062
Publikováno v:
International Journal of Pharmaceutics. 635:122710
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a07c0fbd2d7d1986942fde34a5a0f46
https://doi.org/10.1016/j.ijpharm.2023.122710
https://doi.org/10.1016/j.ijpharm.2023.122710
New Insights on Warfarin Sodium 2-Propanol Solvate Solid-State Changes Using a Multivariate Approach
Autor:
Simon Bates, Harsh S. Shah, Rutesh H. Dave, Kaushalendra Chaturvedi, Kenneth R. Morris, Rahul V. Haware
Publikováno v:
Crystal Growth & Design. 20:7328-7340
A primary anti-coagulant narrow therapeutic index warfarin sodium poses a high risk of thrombosis or excessive bleeding with a sudden death. The root cause for these risks are not well established....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee730045dd9eaf1c2abe0d01ebd1f185
https://doi.org/10.1021/acs.cgd.0c01003
https://doi.org/10.1021/acs.cgd.0c01003
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 17, Pp 9690-9701 (2020)
ACS Omega, Vol 5, Iss 17, Pp 9690-9701 (2020)
In the literature, it is reported that eutectics lead to the enhanced dissolution of a poorly soluble compound. However, the solubility theory suggests that since crystal structures of two components are unchanged that all else being equal, the disso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615f736c767a231f9f3fbaae7355e416
http://europepmc.org/articles/PMC7203706
http://europepmc.org/articles/PMC7203706
Publikováno v:
Molecular pharmaceutics. 19(1)
The molecular basis of adhesion leading to sticking was investigated by exploring the correlation between thermal analysis and molecular simulations. It is hypothesized that intermolecular interactions between a drug molecule and a punch face are the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef59621fdc7e18848f7eba6fbc60b54
https://pubmed.ncbi.nlm.nih.gov/34905926
https://pubmed.ncbi.nlm.nih.gov/34905926
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
The purpose of the present study was to prepare Orodispersible films (ODFs) loaded with ketoprofen nanoparticles (KT-NP). The Box-Behnken design was constructed in developing and optimizing the KTF-NP-ODFs. The effect of independent variables: Solupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6febc810ec298b0ce5d0b3dfaae75dfe
https://pubmed.ncbi.nlm.nih.gov/34678275
https://pubmed.ncbi.nlm.nih.gov/34678275
Publikováno v:
International Journal of Pharmaceutics. 559:348-359
A Design of Experiment (DoE) methodology was adopted to investigate and optimize process parameters and formulations variables for preparing an amorphous clotrimazole (CLT) nanosuspension by sonoprecipitation technique. The amorphous nanosuspension c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4907c6245df9e897708c2856c76c47f0
https://doi.org/10.1016/j.ijpharm.2019.01.054
https://doi.org/10.1016/j.ijpharm.2019.01.054
Publikováno v:
Molecular pharmaceutics. 18(4)
The current research work focuses on understanding the reported discrepancies and our observations in the dissolution profiles of warfarin sodium tablets and potential patient-based failure modes during oral warfarin therapy. It was hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ac7d14ae350d4e6a8ced2112305608
https://pubmed.ncbi.nlm.nih.gov/33689375
https://pubmed.ncbi.nlm.nih.gov/33689375
Publikováno v:
Drug development and industrial pharmacy. 46(3)
The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a quality-by-design (QbD) approach. The BCS class II drug IBU was sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a1e74ac9b96164fd594012d0ec7546
https://pubmed.ncbi.nlm.nih.gov/32037896
https://pubmed.ncbi.nlm.nih.gov/32037896