Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Rute A, Tomaz"'
1
Akademický článek
Generation of functional hepatocytes by forward programming with nuclear receptors
Autor: Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Publikováno v: eLife, Vol 11 (2022)
Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSCs) into hepatocyte-like cells (HLCs) provides an adva
Externí odkaz: https://doaj.org/article/07a94c8ea33a4c4d9ca24e8d7b3c1339
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2
Akademický článek
Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
Autor: Emma Bell, Edward W. Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, Rute A. Tomaz, King Hang T. Mau, Yaser Atlasi, Roshni A. de Souza, Hendrik Marks, Hendrik G. Stunnenberg, Alice Jouneau, Véronique Azuara
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Clusters of enhancers, called super-enhancers (SEs), control the expression of cell identity genes. Here, the authors identify two types of enhancer units within SEs in ESCs, characterised by distinctive CpG methylation dynamics, and find that ESRRB
Externí odkaz: https://doaj.org/article/5299ca445e9743b2869fc3fe2a1a17ce
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3
Akademický článek
Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics
Autor: Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Publikováno v: Stem Cell Reports, Vol 12, Iss 1, Pp 165-179 (2019)
Summary: Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these interplays at the molecular level remains challenging due to the lack of efficient methods allowing cell c
Externí odkaz: https://doaj.org/article/1845b195505f44a78af9a9414bb07768
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7
Modeling Disease with Human Inducible Pluripotent Stem Cells
Autor: Ludovic Vallier, Rodrigo A. Grandy, Rute A. Tomaz
Publikováno v: Annual Review of Pathology: Mechanisms of Disease
Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to advancing this enterprise, their limitation in modeling all the aspects of complex human dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da29db177b1069dae6376ba908a41015
https://doi.org/10.1146/annurev-pathol-020117-043634
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8
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation
Autor: Daniel Ortmann, Daniele Muraro, Laura G. Reinholdt, Brandon T Wesley, Ludovic Vallier, Daniel A. Skelly, Christopher L. Baker, Ted Choi, Yuanhua Huang, Peter J. Rugg-Gunn, Rute A. Tomaz, Steven C. Munger, Stephanie Brown, Anna Osnato, Gary A. Churchill, Anne Czechanski, Selcan Aydin, Oliver Stegle, Giovanni Canu
Publikováno v: Cell Stem Cell
Summary Variability among pluripotent stem cell (PSC) lines is a prevailing issue that hampers not only experimental reproducibility but also large-scale applications and personalized cell-based therapy. This variability could result from epigenetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88e736e49dc0b59182dc8b3ba295dec
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9
Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
Autor: Edward Curry, Véronique Azuara, King Hang T. Mau, Roshni A. de Souza, Vincent Brochard, Alice Jouneau, Rute A. Tomaz, Luc Jouneau, Wout Megchelenbrink, Emma Bell, Hendrik Marks, Yaser Atlasi, Hendrik G. Stunnenberg
Publikováno v: 3rd Annual Meeting
3rd Annual Meeting, Nov 2019, Lyon, France
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩
www.nature.com
3rd Annual Meeting, French Society for Stem Cell Research. Corbeil-Essonne, FRA., Nov 2019, Lyon, France
Nature Communications, 11, 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, 11
Nature Communications 1 (11), . (2020)
Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c04223cda3855ff63c5fe907d1490
https://www.repository.cam.ac.uk/handle/1810/304967
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