Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives

Autor: Andrius Sakalauskas, Mantas Ziaunys, Ruta Snieckute, Vytautas Smirnovas

Publikováno v: Antioxidants, Vol 10, Iss 9, p 1428 (2021)

The increasing prevalence of amyloid-related disorders, such as Alzheimer’s or Parkinson’s disease, raises the need for effective anti-amyloid drugs. It has been shown on numerous occasions that flavones, a group of naturally occurring anti-oxida

Externí odkaz: https://doaj.org/article/9486b2032bc34a828370331c915a724f

Temperature-dependent structural variability of prion protein amyloid fibrils

Autor: Andrius Sakalauskas, Ruta Snieckute, Kamile Mikalauskaite, Mantas Ziaunys, Vytautas Smirnovas

Publikováno v: International journal of molecular sciences, Basel : MDPI, 2021, vol. 22, no. 10, art. no. 5075, p. [1-16]
International Journal of Molecular Sciences, Vol 22, Iss 5075, p 5075 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 10

Prion protein aggregation into amyloid fibrils is associated with the onset and progression of prion diseases—a group of neurodegenerative amyloidoses. The process of such aggregate formation is still not fully understood, especially regarding thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971c5db1a6e0ccfaf403dd541c73e69e
https://repository.vu.lt/VU:ELABAPDB103436919&prefLang=en_US

Formation of amyloid fibrils by the regulatory 14-3-3ζ protein

Autor: Darius Šulskis, Mantas Žiaunys, Andrius Sakalauskas, Rūta Sniečkutė, Vytautas Smirnovas

Publikováno v: Open Biology, Vol 14, Iss 1 (2024)

The 14-3-3 proteins are a highly conserved adaptor protein family with multi-layer functions, abundantly expressed in the brain. The 14-3-3 proteins modulate phosphorylation, regulate enzymatic activity and can act as chaperones. Most importantly, th

Externí odkaz: https://doaj.org/article/d217ce2745ca4064aeff7d6151acecab