Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Ruta Bruvere"'
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Akademický článek
The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response
Autor: Juris Jansons, Irina Sominskaya, Natalia Petrakova, Elizaveta S. Starodubova, Olga A. Smirnova, Ekaterina Alekseeva, Ruta Bruvere, Olesja Eliseeva, Dace Skrastina, Elena Kashuba, Marija Mihailova, Sergey N. Kochetkov, Alexander V. Ivanov, Maria G. Isaguliants
Publikováno v: Cells, Vol 8, Iss 3, p 208 (2019)
HCV core is an attractive HCV vaccine target, however, clinical or preclinical trials of core-based vaccines showed little success. We aimed to delineate what restricts its immunogenicity and improve immunogenic performance in mice. We designed plasm
Externí odkaz: https://doaj.org/article/17bde8c3e2fd48d69f7ffa6d982df1aa
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2
The immunogenicity in mice of hepatitis C virus core protein delivered as DNA is modulated by its capacity to promote ROS production and activate Nrf2/ARE pathway
Autor: Skrastina Dace, Paul Pumpen, Elena Kashuba, Elizaveta Starodubova, Olga A. Smirnova, Ruta Bruvere, Marija Mihailova, Irina Sominskaya, Olesja Eliseeva, Natalia Petrakova, Alexander V. Ivanov, Juris Jansons, Maria G. Isaguliants
Publikováno v: Free Radical Biology and Medicine. 128:S105-S106
Hepatitis C virus (HCV) core protein is an attractive target for HCV vaccine, however little progress was achieved in trials. We aimed to delineate the factors restricting immunogenicity of HCV core, and to improve its performance as DNA immunogen in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f974687bb4648d403e6cf5e69354cde1
https://doi.org/10.1016/j.freeradbiomed.2018.10.253
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3
Recombinant Semliki Forest virus vectors encoding hepatitis B virus small surface and pre-S1 antigens induce broadly reactive neutralizing antibodies
Autor: Henrik Garoff, Tatjana Kozlovska, Anna Zajakina, Paul Pumpens, Ruta Bruvere, Wolfram H. Gerlich, A. Bogdanova, Dace Skrastina, Velta Ose, Baiba Niedre-Otomere, Dieter Glebe
Publikováno v: Journal of Viral Hepatitis. 19:664-673
Most hepatitis B virus (HBV) vaccines consist of viral small surface (S) protein subtype adw2 expressed in yeast cells. In spite of good efficacy, HBV-genotype and subtype differences, escape mutants and insufficient Th1 activation remain potential p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b9429fff8ee294d8e835942f254d9e0
https://doi.org/10.1111/j.1365-2893.2012.01594.x
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4
Fluorescent Probe ABM and Estimation of Immune State in Patients with Different Pathologies (Review Article)
Autor: Natalija Gabruseva, Tija Zvagule, Imants Meirovics, Gunta Kizane, Elena Kirilova, Ruta Bruvere, Laura Klimkane, Inta Kalnina
Publikováno v: Journal of Fluorescence. 20:9-17
The fluorescent probe ABM (3-aminobenzanthrone derivative) one of the fluorescent probes synthesized in Riga Technical University proved to be an excellent, independent model for studying cell membranes. In our work we have investigated the possibili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3660c69eee56968dc84f43444561b2f3
https://doi.org/10.1007/s10895-009-0515-6
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5
[Untitled]
Autor: G. Feldmane, Ruta Bruvere, Natalija Gabruseva, I. Kalniņa, Imants Meirovics
Publikováno v: Journal of Fluorescence. 13:149-156
Properties of the naphthalic acid derivative 3-isopropyloxy-6-morpholino-2-phenilphenalen-1-ona (PMPH) as a potential fluorescent probe were investigated. Spectral characteristics of the compound in different solvents as well as their binding to mode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::960f92779c5597dfdb4ab89d4f486952
https://doi.org/10.1023/a:1022987025901
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6
Posttranslational modifications and secretion efficiency of immunogenic hepatitis B virus L protein deletion variants
Autor: Velta Ose, Dieter Glebe, Baiba Niedre-Otomere, Wolfram H. Gerlich, Ance Bogdanova, Tatjana Kozlovska, Ruta Bruvere, Paul Pumpens
Publikováno v: Virology Journal
Background Subviral particles of hepatitis B virus (HBV) composed of L protein deletion variants with the 48 N-terminal amino acids of preS joined to the N-terminus of S protein (1-48preS/S) induced broadly neutralizing antibodies after immunization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6916fd4a1f1af5fb5cdc7ddb4b1136bf
https://pubmed.ncbi.nlm.nih.gov/23442390
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7
Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments
Autor: Viesturs Baumanis, Irina Sominskaya, Ivars Petrovskis, Velta Ose, Janis Bogans, Irena Timofejeva, Inara Akopjana, Ruta Bruvere, Pauls Pumpens, Renate Ranka, Kalvis Brangulis
Publikováno v: Nanomedicine : nanotechnology, biology, and medicine. 9(1)
Virus-like particles (VLPs) are created by the self-assembly of multiple copies of envelope and/or capsid proteins from many viruses, mimicking the conformation of a native virus. Such noninfectious nanostructures are mainly used as antigen-presentin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fa8c7093056f79ded16275ae894209
https://pubmed.ncbi.nlm.nih.gov/22633898
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8
Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer
Autor: A. Stengrevics, Aija Line, Ruta Bruvere, Natalija Gabruseva, Shitsu Barnikol-Watanabe, Karina Silina, M. Leja, Z. Kalnina
Publikováno v: Europe PubMed Central
European Journal of Histochemistry, Vol 53, Iss 1, Pp e2-e2 (2009)
European Journal of Histochemistry : EJH
European Journal of Histochemistry, Vol 53, Iss 1, Pp 7-18 (2009)
NUCB2 is an EF-hand Ca2+ binding protein that has been implicated in various physiological processes like calcium homeostasis, hypothalamic regulation of feeding and TNF receptor shedding. In our previous study we identified NUCB2 as a potential tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ab7d8f2c20b4d27f0355509c0ac047
https://pubmed.ncbi.nlm.nih.gov/19351608
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9
Structural changes in lymphocytes membrane of Chernobyl clean-up workers from Latvia
Autor: Andris Kesters, Imants Meirovics, Tija Zvagule, Inta Kalnina, Georgijs Kirilovs, Ruta Bruvere, Natalja Kurjane, Gunta Kizane, Jelena Kirilova, Natalija Gabruseva
Publikováno v: Journal of fluorescence. 17(6)
ABM (3-aminobenzanthrrone derivative) developed at the Riga Technical University, Riga, Latvia) has been previously shown as a potential probe for determination of the immune state of patients with different pathologies . The fist study (using probe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8274a63e1331f7e82a862837be9b75ce
https://pubmed.ncbi.nlm.nih.gov/17924176
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10
Proteasomal degradation of core protein variants from chronic hepatitis B patients
Autor: Ruta Bruvere, Sabine Braun, Velta Ose, Tatyana Kozlovska, Henrik Garoff, Helga Meisel, Anna Zajakina, Paul Pumpens, Anatoly Sharipo, Jekaterina Aleksejeva
Publikováno v: Journal of medical virology. 79(9)
The accumulation of complex hepatitis B virus (HBV) variants with internal in-frame deletions in the C gene in immunosuppressed renal transplant recipients is associated with a severe course of the infection leading to end-stage liver disease (ESLD).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1decf688cb7425f88d4dff4a25c3871d
https://pubmed.ncbi.nlm.nih.gov/17607782
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