Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

Autor: Alan Percy, Cathy Wood-Siverio, Oksana Suchowersky, Claudia Testa, Yvette Bordelon, Kevin M. Biglan, Francis O. Walker, David P. Richman, Rustom Sethna, Eric Siemers, Shirley Eberly, Marie Saint-Hilaire, Alicia Brocht, Madaline B. Harrison, Richard H. Myers, Carlos Singer, Karen Blindauer, Rajeev Ananda Kumar, Jody Goldstein, Diana Rosas, Anne Young, Charles H. Adler, Kimberly Quaid, James F. Gusella, Carolyn Gray, Penelope Hogarth, James B. Caress, J. B. Penney, Kelvin L. Chou, Teresa Tempkin, Christopher Ross, Jody Corey-Bloom, Brad Racette, Victoria Hunt, William Weiner, Thomas D. Bird, J. Decolongon, Greg Suter, Eric Molho, Megan Romer, Blair Leavitt, Mary Lou Klimek, Hillary Lipe, Peter Como, Dawn Radtke, Constance Nickerson, Roger L. Albin, Karen Marder, Marcy E. MacDonald, Sandra Kostyk, Christine Weaver, David Oakes, William Mallonee, Amy Duffy, Tatiana Foroud, Marguerite Wieler, Clifford W. Shults, Sarah Furtado, Julie C. Stout, William C. Johnson, Timothy Greenamyre, Ira Shoulson, Carol Moskowitz, J.S. Paulsen, Karl Kieburtz, Lauren Seeberger, Douglas Hobson, Scott R. Bundlie, Steven M. Hersch, Leon S. Dure, Arthur Watts, Vicki L. Wheelock, Donald S. Higgins, Lorne A. Clarke, Stanley Fahn, Nestor Galvez-Jimenez, Andrew Feigin, Lynn A. Raymond, Joseph Jankovic, Sylvain Chouinard, Caroline M. Tanner, Melissa Wesson, Barbara Shannon, Marie Cox, Cynthia L. Comella, John N. Caviness, Guerry M. Peavy, Adam Rosenblatt, Robert A. Hauser, Carol Zimmerman, Christine Hunter, Christine O'Neill, Juan Sanchez-Ramos, Corrine Baic, Peter Novak, Sharon Evans, Hongwei Zhao, Stewart A. Factor, W.R. Wayne Martin, Candace Cotto, Richard Dubinsky, David D. Song, M. Aileen Shinaman, Susan B. Perlman, Joel S. Perlmutter, Ali Samii, Elise Kayson, Mark Guttman, Frederick J. Marshall, Kathleen L. Shannon, M. Nance

Publikováno v: JAMA neurology. 73(1)

Identifying measures that are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis of Huntington disease (HD) has implications for designing clinical trials.To identify the earliest features associated with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa05623ec4df08194f06e5de9f4bc97
https://pubmed.ncbi.nlm.nih.gov/26569098

Placebo response in refractory tardive akathisia

Autor: Gary Remington, Rustom Sethna, Luis Fornazzari

Publikováno v: Canadian journal of psychiatry. Revue canadienne de psychiatrie. 38(4)

A double-blind, crossover drug trial with a patient with treatment-resistant tardive akathisia is described. The finding of a placebo response was unexpected, but emphasizes the value of such an approach in refractory cases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88f1d340496bb0832aa767c8f95b74f
https://pubmed.ncbi.nlm.nih.gov/8100184