Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rustom Falahati"'
Autor:
Bradford A. Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C. Brock, Bhupinder Singh, Alan T. Chang, Jeremy A. O’Sullivan, Robert P. Schleimer, Nenad Tomasevic, Christopher R. Bebbington, Bruce S. Bochner
Publikováno v:
Cells, Vol 10, Iss 1, p 19 (2020)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosi
Externí odkaz:
https://doaj.org/article/3a9df22d546640558f4cd6fc839dc654
Autor:
Emily C. Brock, Rustom Falahati, Bhupinder Singh, Bradford A. Youngblood, Jeremy A. O'Sullivan, Christopher R. Bebbington, Robert P. Schleimer, Julia Schanin, Nenad Tomasevic, Bruce S. Bochner, Jason Williams, Alan T. Chang, John Leung
Publikováno v:
Cells, Vol 10, Iss 19, p 19 (2021)
Cells
Cells
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosi
Autor:
Jason Williams, Leonard D. Shultz, Dale L. Greiner, Bradford A. Youngblood, Nenad Tomasevic, John Leung, Michael A. Brehm, Christopher R. Bebbington, Jessica M. Bright, Emily C. Brock, Paul J. Bryce, Rustom Falahati
Publikováno v:
International Archives of Allergy and Immunology. 180:91-102
Introduction: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast
Autor:
Bradford A. Youngblood, Henrik S. Rasmussen, Rustom Falahati, Nenad Tomasevic, Emily C. Brock, John Leung, Christopher R. Bebbington, Kathryn A. Peterson, Bruce S. Bochner
Publikováno v:
JCI Insight. 4
Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis (EGE)
Publikováno v:
Gene Therapy
Neonatal AAV8-mediated Factor IX (F.IX) gene delivery was applied as a model for exploring mechanisms of tolerance induction during immune ontogeny. Intraperitoneal delivery of AAV8/ Factor IX (hF.IX) during weeks 1-4 of life, over a 20-fold dose ran
Autor:
Yimin Shi, Linda Flebbe-Rehwaldt, Stanton L. Gerson, Jianqing Zhang, Rustom Falahati, Karin M.L. Gaensler
Publikováno v:
Molecular Therapy. 20(11):2180-2189
The feasibility of allogeneic transplantation, without myeloablation or post-transplant immunosuppression, was tested using in vivo chemoselection of allogeneic hematopoietic stem cells (HSCs) after transduction with a novel tricistronic lentiviral v
Autor:
Dallen Herzog, David Leitenberg, Weiping Shen, Stephan Ladisch, Cathy Southammakosane, Elisabeth Mari, Erik J. Stemmy, Rustom Falahati, Alessandra Jales
Publikováno v:
Immunology. 132:134-143
Summary Tumour pathogenesis is characterized by an immunosuppressive microenvironment that limits the development of effective tumour-specific immune responses. This is in part the result of tumour-dependent recruitment and activation of regulatory c
Publikováno v:
Immunology. 121:545-554
Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 wi
Autor:
Rustom Falahati, David Leitenberg
Publikováno v:
The Journal of Immunology. 178:2056-2064
CD45-dependent dephosphorylation of the negative regulatory C-terminal tyrosine of the Src family kinase Lck, promotes efficient TCR signal transduction. However, despite the role of CD45 in positively regulating Lck activity, the distinct phenotypes
Autor:
Leonard D. Shultz, Nenad Tomasevic, Christopher R. Bebbington, Michael A. Brehm, Dale L. Greiner, Paul J. Bryce, Rustom Falahati, Rebecca Krier, Chia-Lin Hsu, Laurie L. Kenney, John Leung
Publikováno v:
The Journal of allergy and clinical immunology. 138(3)
Background Mast cells are a critical component of allergic responses in humans, and animal models that allow the in vivo investigation of their contribution to allergy and evaluation of new human-specific therapeutics are urgently needed. Objective T