Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rustem Krykbaev"'
Publikováno v:
Nucleic Acids Research. 50:W246-W253
Proteins with similar phylogenetic patterns of conservation or loss across evolutionary taxa are strong candidates to work in the same cellular pathways or engage in physical or functional interactions. Our previously published tools implemented our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d42d9a8583d5150a148d12e8441d2ae
https://doi.org/10.1093/nar/gkac349
https://doi.org/10.1093/nar/gkac349
Autor:
Debra G. Goodwin, Tarek S. Mansour, Kenneth C. Appell, Katherine J. Seidl, Amha G. Hewet, Maria L. Webb, Min Gao, James D. Clark, Steve Tam, Martin Hegen, Elizabeth Quadros, Peter T. Symanowicz, Jenny Togias, Jennifer Lussier, Scott H. Schelling, Michael Ohlmeyer, Bojing Wang, Xin Xu, Earl F. Kimble, Mary Collins, Jorge Quintero, Rustem Krykbaev, Dejun Xuan, Cheryl Nickerson-Nutter, Richard Harrison, Yuefei Shao, Christopher Wrocklage, Tsung H. Lin, Andrew G. Cole
Publikováno v:
Arthritis & Rheumatism. 62:2283-2293
Objective All γ-chain cytokines signal through JAK-3 and JAK-1 acting in tandem. We undertook this study to determine whether the JAK-3 selective inhibitor WYE-151650 would be sufficient to disrupt cytokine signaling and to ameliorate autoimmune dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef4a0c33e1ad1789a4ae6c55e946b7c
https://doi.org/10.1002/art.27536
https://doi.org/10.1002/art.27536
Autor:
Rustem Krykbaev, Jill F. Wright, Neil M. Wolfman, Joseph Stock, Lori Fitz, Amira Quazi, Benfang H. Ruan, Margaret Fleming, Karen Page, Paul Wu, Derek C. Cole, Nelson Huang, Karl Nocka, Ann Aulabaugh
Publikováno v:
Analytical Biochemistry. 399:284-292
Vanin-1 is a pantetheinase that catalyzes the hydrolysis of pantetheine to produce pantothenic acid (vitamin B5) and cysteamine. Reported here is a highly sensitive fluorescent assay using a novel fluorescently labeled pantothenate derivative. The as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b834c1114472eda2bd6b617b835745fb
https://doi.org/10.1016/j.ab.2009.12.010
https://doi.org/10.1016/j.ab.2009.12.010
Autor:
Margaret Fleming, Rustem Krykbaev, Stanley F. Wolf, Padmalatha S. Reddy, Lori Fitz, Aaron Winkler, Xiaoke Yang, Dejun Xuan
Publikováno v:
Gene. 452:63-71
Acidic mammalian chitinase (AMCase), an enzyme implicated in the pathology of asthma, is capable of chitin cleavage at a low pH optimum. The corresponding gene (CHIA) can be found in genome databases of a variety of mammals, but the enzyme properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fc9d91f5264afdb10db4b8c5bc810b
https://doi.org/10.1016/j.gene.2009.12.005
https://doi.org/10.1016/j.gene.2009.12.005
Publikováno v:
Protein Science. 11:2899-2908
Certain antibodies (Abs) elicited using the cardiac glycoside digoxin (digoxigenin tridigitoxoside) bind preferentially to analogs that differ from digoxin by substitutions on the cardenolide rings, the lactone, or by the presence or absence of attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8b05594a78517dcdd6e4bfaf3277bb
https://doi.org/10.1110/ps.0223402
https://doi.org/10.1110/ps.0223402
Autor:
Kimberly Ann Marquette, Joseph P. Sypek, Rustem Krykbaev, Michael D Wadanoli, Franklin J. Schlerman, Marion T. Kasaian, Suresh Vunnum, Wood Nancy L, Bruce A. Jacobson, Lioudmila Tchistiakova, Andrea G Bree, Timothy A. Cook, Xin Xu, Xiang-Yang Tan, Samuel J. Goldman, Angela Widom, Debra D. Donaldson
Publikováno v:
Journal of Allergy and Clinical Immunology. 119:1251-1257
Background Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer of airway inflammation in rodent models of respiratory disease, but a role for IL-13 has not been demonstrated in primat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f22fd41ec804b9e3b31d0b9ca5da3e
https://doi.org/10.1016/j.jaci.2007.02.009
https://doi.org/10.1016/j.jaci.2007.02.009
Publikováno v:
Journal of Biological Chemistry. 276:8149-8158
The heavy-chain CDR3 region of the high affinity (K a = 1.3 × 1010 m − 1) anti-digoxin monoclonal antibody 26-10 was modified previously to shift its specificity, by substitution of tryptophan 100 by arginine, toward binding analogs of digoxin con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec36112d5dd996ed26f12b22d0af245
https://doi.org/10.1074/jbc.m008108200
https://doi.org/10.1074/jbc.m008108200
Publikováno v:
Virology. 234:196-202
Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c564b7df43f199eef1d10a5e51d0ca66
https://doi.org/10.1006/viro.1997.8651
https://doi.org/10.1006/viro.1997.8651
Autor:
Amira Quazi, Jill F. Wright, Karl Nocka, Derek C. Cole, Wen Kuang, Rustem Krykbaev, Samuel J. Goldman, Delia Demers, Theresa Paradis, Cara Williams, Jonathan Brooks, Charlene DeClercq, Lori Fitz, Cedric Hubeau, Margaret Fleming, Aaron Winkler, Brian Bates
Publikováno v:
D31. ANIMAL MODELS OF AIRWAY INFLAMMATION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952d23c1b5fc477787287e6d7f09bf40
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5594
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5594
Autor:
Yuchuan Wu, Paul Morgan, Nathan O. Fuller, Wei Li, Samuel J. Goldman, Raveglia Luca Francesco, Cara M. M. Williams, Rustem Krykbaev, Joseph P. Sypek, Kristina Cunningham, Junjun Wu, William W Abraham, Fabio Rancati, Xin Xu, Steve Tam, Jianchang Li, Susan Fish, Tarek S. Mansour, Stefania Vallese, Rajeev Hotchandani
Publikováno v:
Journal of medicinal chemistry. 52(17)
MMP-12 plays a significant role in airway inflammation and remodeling. Increased expression and production of MMP-12 have been observed in the lungs of asthmatic patients. Compound 27 was identified as a potent and selective MMP-12 inhibitor possessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f793a6a9bdbb17167c21f086cb947804
https://pubmed.ncbi.nlm.nih.gov/19725580
https://pubmed.ncbi.nlm.nih.gov/19725580