Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Russell Watts"'
Autor:
Haizhen Wang, Cyrus Nikain, Konstantinos I. Fortounas, Jaume Amengual, Ozlem Tufanli, Maxwell La Forest, Yong Yu, Meng C. Wang, Russell Watts, Richard Lehner, Yunping Qiu, Min Cai, Irwin J. Kurland, Ira J. Goldberg, Sujith Rajan, M. Mahmood Hussain, Jeffrey L. Brodsky, Edward A. Fisher
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102048- (2024)
Objective: Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that facilitate this association is incompletely understood. FITM2, an integral endoplas
Externí odkaz:
https://doaj.org/article/98f69e2137b44289b6b69aa78d3204eb
Autor:
Jihong Lian, Russell Watts, Ariel D. Quiroga, Megan R. Beggs, R. Todd Alexander, Richard Lehner
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 880-891 (2019)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Triacylglycerol accumulation in the liver is a hallmark of NAFLD. Metabolic studies have confirmed that increased hepatic de novo lipogenesis (DNL) in humans contribut
Externí odkaz:
https://doaj.org/article/ea5f907a104f4d9ab0fb45ec57867f62
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100093- (2021)
The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play roles in hepatic triacylglycer
Externí odkaz:
https://doaj.org/article/af94da54767141b7abd24b951a8c83f3
Autor:
Siva S. V. P. Sakamuri, Russell Watts, Abhijit Takawale, Xiuhua Wang, Samuel Hernandez-Anzaldo, Wesam Bahitham, Carlos Fernandez-Patron, Richard Lehner, Zamaneh Kassiri
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated following
Externí odkaz:
https://doaj.org/article/fa68f747eb244e7984495198cb3a085e
Autor:
Caleb C. Lord, Daniel Ferguson, Gwynneth Thomas, Amanda L. Brown, Rebecca C. Schugar, Amy Burrows, Anthony D. Gromovsky, Jenna Betters, Chase Neumann, Jessica Sacks, Stephanie Marshall, Russell Watts, Martina Schweiger, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Justin D. Lathia, Takuya F. Sakaguchi, Richard Lehner, Guenter Haemmerle, Rudolf Zechner, J. Mark Brown
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 939-949 (2016)
Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought to regulate TAG mobilization by stimulating the enzymatic activity of ATGL. However, it is
Externí odkaz:
https://doaj.org/article/d66246b7b7b944b08b3d090febecf391
Autor:
Marcia L.E. MacDonald, Roshni R. Singaraja, Nagat Bissada, Piers Ruddle, Russell Watts, Joanna M. Karasinska, William T. Gibson, Catherine Fievet, Jean E. Vance, Bart Staels, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 217-229 (2008)
A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the “metabolic syndrome,” is known to increase the risk of developing cardiovascular disease and diabetes. St
Externí odkaz:
https://doaj.org/article/17a351d051934869b33eaae8b8be0504
Autor:
Aashiq Hussain, Jihong Lian, Russell Watts, Tomás Gutiérrez, Randal Nelson, Ing Swie Goping, Richard Lehner
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1867(4)
Accumulating evidence suggests that hyperlipidemia is associated with obesity and cancer mortality in humans. We tested the hypotheses that inhibition of microsomal triglyceride transfer protein (MTP) would attenuate obesity-induced hyperlipidemia an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85933b63c499712df1bdda3906efde9b
https://pubmed.ncbi.nlm.nih.gov/35150894
https://pubmed.ncbi.nlm.nih.gov/35150894
Hepatic steatosis is defined by accumulation of neutral lipids in lipid droplets (LDs) including triacylglycerol (TG) and steryl esters. Two distinct diacylglycerol acyltransferases (DGAT1 and DGAT2) catalyze synthesis of TG in hepatocytes. TG formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97946d024ea707a49b1350ad957f2733
https://doi.org/10.1101/2021.06.18.449045
https://doi.org/10.1101/2021.06.18.449045
Publikováno v:
L'Esprit Créateur, 2002 Oct 01. 42(3), 70-80.
Externí odkaz:
https://www.jstor.org/stable/26288388
Autor:
Megan R Beggs, Jihong Lian, Russell Watts, Ariel D. Quiroga, R. Todd Alexander, Richard Lehner
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Lipid Research, Vol 60, Iss 4, Pp 880-891 (2019)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Lipid Research, Vol 60, Iss 4, Pp 880-891 (2019)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Triacylglycerol accumulation in the liver is a hallmark of NAFLD. Metabolic studies have confirmed that increased hepatic de novo lipogenesis (DNL) in humans contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9618adaf9fc4ec2fe29178ee31b1cec7
https://doi.org/10.1194/jlr.m092544
https://doi.org/10.1194/jlr.m092544