Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Russell T. Naven"'
Autor:
Lisa Beilke, Lidiya Stavitskaya, Penny Leavitt, Alexander Amberg, Donald P. Quigley, Angela White, James Harvey, Naomi L. Kruhlak, Raymond Kemper, Craig Zwickl, Claire L. Neilan, Ernst Ahlberg, Kevin P. Cross, Joerg Wichard, Glenn J. Myatt, Dana Shuey, Hans-Peter Spirkl, Michelle O. Kenyon, Masamitsu Honma, Robert A. Jolly, David Bower, Elisabeth Joossens, Jacky Van Gompel, Lara Kuhnke, Laura Custer, Kevin A. Ford, Russell T. Naven, Andrew Teasdale
Publikováno v:
Regulatory Toxicology and Pharmacology. 77:1-12
Statistical-based and expert rule-based models built using public domain mutagenicity knowledge and data are routinely used for computational (Q)SAR assessments of pharmaceutical impurities in line with the approach recommended in the ICH M7 guidelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e433017dbcf484af3c46d7c78df622
https://doi.org/10.1016/j.yrtph.2016.02.003
https://doi.org/10.1016/j.yrtph.2016.02.003
Publikováno v:
Toxicological Sciences. 131:271-278
Mitochondrial dysfunction has been implicated as an important factor in the development of idiosyncratic organ toxicity. An ability to predict mitochondrial dysfunction early in the drug development process enables the deselection of those drug candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27ac784dd6facf4fef513884555573d
https://doi.org/10.1093/toxsci/kfs279
https://doi.org/10.1093/toxsci/kfs279
Autor:
Jan van Benthem, David Jacobson-Kram, Véronique Thybaud, Masamitsu Honma, Rosalie K. Elespuru, Richard M. Walmsley, Jiri Aubrecht, Russell T. Naven, Stephen D. Dertinger, Paul D. White, George R. Douglas, Jennifer C. Sasaki, Marilyn J. Aardema, R. Daniel Benz, Albert J. Fornace, Marlies De Boeck, Patricia A. Escobar, Anthony M. Lynch, Eiji Yamamura, Robert H. Schiestl, James H. Kim, James F. Rusling
Publikováno v:
Environmental and Molecular Mutagenesis. 52:205-223
The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b881580e5ed072abe6e0faea67f8c4
https://doi.org/10.1002/em.20614
https://doi.org/10.1002/em.20614
Autor:
Michael B. Hursthouse, Mark Mascal, Russell T. Naven, Ross A. Edwards, Ralf Warmuth, David E. Hibbs
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3435-3441
An efficient and versatile synthetic route to calixhydroquinones is described. These macrocycles are activated towards meta substitution, and reaction with bromine gives the first examples of persubstituted, phenol-derived calixarenes. The effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b3e2345a301e24d57f8e626a20782b
https://doi.org/10.1039/a906442g
https://doi.org/10.1039/a906442g
Publikováno v:
Expert opinion on drug metabolismtoxicology. 8(12)
Computational approaches for genotoxicity prediction have existed for over two decades. Numerous methodologies have been utilized and the results of various evaluations have published.In silico methods are considered mature enough to be part of draft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019d425f5e1bb8a575820dbe827fdae9
https://pubmed.ncbi.nlm.nih.gov/22998164
https://pubmed.ncbi.nlm.nih.gov/22998164
Autor:
Nigel Greene, Lilia Fisk, Russell T. Naven, Reine R. Note, Mukesh L. Patel, Dennis J. Pelletier
Publikováno v:
Chemical research in toxicology. 23(7)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd76c6e90ffddf6cf46affcd7099bbf
https://pubmed.ncbi.nlm.nih.gov/20553011
https://pubmed.ncbi.nlm.nih.gov/20553011
Publikováno v:
Expert opinion on drug metabolismtoxicology. 6(7)
The computational prediction of genotoxicity is important to the early identification of those chemical entities that have the potential to cause carcinogenicity in humans.The review discusses key scientific developments in the prediction of Ames mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a253ac65962e494db3ca8d3a1be8e0
https://pubmed.ncbi.nlm.nih.gov/20528613
https://pubmed.ncbi.nlm.nih.gov/20528613
Autor:
David E. Hibbs, Ross A. Edwards, Ralf Warmuth, Mark Mascal, Russell T. Naven, Michael B. Hursthouse
Publikováno v:
ChemInform. 31
An efficient and versatile synthetic route to calixhydroquinones is described. These macrocycles are activated towards meta substitution, and reaction with bromine gives the first examples of persubstituted, phenol-derived calixarenes. The effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::705591915d71e2308234ab37671530eb
https://doi.org/10.1002/chin.200019086
https://doi.org/10.1002/chin.200019086
Autor:
Claire A. Minshull, Julie A. Tucker, Stephen Green, Philip J. Jewsbury, Rebecca Ellston, J. Elizabeth Pease, Catherine J. Midgley, Beattie John Franklin, Richard A. Pauptit, Gloria Anne Breault, Russell T. Naven
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b9e27c5d13f9d520d5e14fc7d1bf31
https://pubmed.ncbi.nlm.nih.gov/12941311
https://pubmed.ncbi.nlm.nih.gov/12941311
Publikováno v:
Toxicology Letters. 196:S205-S206
Adverse reactions leading to the withdrawal of therapeutic drugs from the market are a serious issue for pharmaceutical companies Chemically-induced mitochondrial 1 Lhasa Limited, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, UK 2 Worldwide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b73014f81bc6f196999b3ac80b80cf
https://doi.org/10.1016/j.toxlet.2010.03.694
https://doi.org/10.1016/j.toxlet.2010.03.694