Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Russell R. Broaddus"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Endometrial carcinoma (EC) is the most diagnosed gynecological malignancy in Western countries. Both incidence and mortality rates of EC have steadily risen in recent years. Despite generally favorable prognoses for patients with the endometrioid typ
Externí odkaz:
https://doaj.org/article/9c2d4b89702a4c768f234ad58e322c02
Autor:
Elizabeth H. Stover, Niya Xiong, Andrea P. Myers, Nabihah Tayob, Victoria Engvold, Madeline Polak, Russell R. Broaddus, Vicky Makker, Ronny Drapkin, Joyce F. Liu, Neil S. Horowitz, Funda Meric-Bernstam, Carol Aghajanian, Robert L. Coleman, Gordon B. Mills, Lewis C. Cantley, Ursula A. Matulonis, Shannon N. Westin, Panagiotis A. Konstantinopoulos
Publikováno v:
Gynecologic Oncology Reports, Vol 40, Iss , Pp 100974- (2022)
Uterine serous carcinoma (USC) is an uncommon subtype of endometrial cancer with a poor prognosis. USCs have genomic alterations in the PI3K pathway. A prior phase II study of AKT inhibitor MK-2206 (an allosteric AKT inhibitor, primarily affecting AK
Externí odkaz:
https://doaj.org/article/9a6dad8bf1b54f1fada0cfe8b5c09232
Autor:
Apostolia-Maria Tsimberidou, David S. Hong, Jennifer J. Wheler, Gerald S. Falchook, Filip Janku, Aung Naing, Siqing Fu, Sarina Piha-Paul, Carrie Cartwright, Russell R. Broaddus, Graciela M. Nogueras Gonzalez, Patrick Hwu, Razelle Kurzrock
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background In 2007, we initiated IMPACT, a precision medicine program for patients referred for participation in early-phase clinical trials. We assessed the correlation of factors, including genomically matched therapy, with overall surviva
Externí odkaz:
https://doaj.org/article/104ff192ed164bfea419fe086138f71a
Autor:
Olivia Jeong, Russell R. Broaddus, Bruce A. Lessey, John I. Risinger, Mark I. Hunter, Tae Hoon Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14596 (2022)
Women with complex atypical hyperplasia (CAH) or early-stage endometrioid endometrial cancer (EEC) are candidates for fertility preservation. The most common approach is progesterone (P4) therapy and deferral of hysterectomy until after completion of
Externí odkaz:
https://doaj.org/article/705f31d412bd4149b3e6827e7a08d845
Autor:
Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R. Broaddus, Ji Yeon Ahn, Jeong Mook Lim, Jae-Wook Jeong
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of GPR64 has not been stu
Externí odkaz:
https://doaj.org/article/30d6d5b13506470bb64ada92e1ae42f1
Autor:
Eleonora Khlebus, Veena K. Vuttaradhi, Thomas Welte, Namrata Khurana, Joseph Celestino, Hannah C. Beird, Curtis Gumbs, Latasha Little, Alejandra Flores Legarreta, Bryan M. Fellman, Tri Nguyen, Barrett Lawson, Sammy Ferri-Borgogno, Samuel C. Mok, Russell R. Broaddus, David M. Gershenson, P. Andrew Futreal, R. Tyler Hillman
Publikováno v:
Molecular Cancer Research. 21:483-494
Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord tumors with few effective treatments for recurrent disease. The objective of this study was to characterize the tumor microenvironment (TME) of primary and recurrent aGCTs and to ident
Autor:
R. Tyler Hillman, Joseph Celestino, Christopher Terranova, Hannah C. Beird, Curtis Gumbs, Latasha Little, Tri Nguyen, Rebecca Thornton, Samantha Tippen, Jianhua Zhang, Karen H. Lu, David M. Gershenson, Kunal Rai, Russell R. Broaddus, P. Andrew Futreal
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss
Externí odkaz:
https://doaj.org/article/aaaf9455dfe54c3aac5bc54116b1802b
Autor:
Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi, Tae Hoon Kim
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits prolife
Externí odkaz:
https://doaj.org/article/95dc71dd3e94470bb7cd1dded4e2f971
Autor:
R. Tyler Hillman, P. Andrew Futreal, David M. Gershenson, Russell R. Broaddus, Samuel C. Mok, Sammy Ferri-Borgogno, Barrett Lawson, Tri Nguyen, Bryan M. Fellman, Alejandra Flores Legarreta, Latasha Little, Curtis Gumbs, Hannah C. Beird, Joseph Celestino, Namrata Khurana, Thomas Welte, Veena K. Vuttaradhi, Eleonora Khlebus
RNA Sequencing QC Metrics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46943888c66a7d69d57cd0cbf4fef713
https://doi.org/10.1158/1541-7786.22725314
https://doi.org/10.1158/1541-7786.22725314
Autor:
R. Tyler Hillman, P. Andrew Futreal, David M. Gershenson, Russell R. Broaddus, Samuel C. Mok, Sammy Ferri-Borgogno, Barrett Lawson, Tri Nguyen, Bryan M. Fellman, Alejandra Flores Legarreta, Latasha Little, Curtis Gumbs, Hannah C. Beird, Joseph Celestino, Namrata Khurana, Thomas Welte, Veena K. Vuttaradhi, Eleonora Khlebus
Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord tumors with few effective treatments for recurrent disease. The objective of this study was to characterize the tumor microenvironment (TME) of primary and recurrent aGCTs and to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72617fb515f528475ebcabb0c455fea0
https://doi.org/10.1158/1541-7786.c.6603389.v2
https://doi.org/10.1158/1541-7786.c.6603389.v2