Výsledky vyhledávání - "Russell R Lonser"

Akademický článek

Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas.

Autor: Joshua L Wang, Rolf F Barth, Robert Cavaliere, Vinay K Puduvalli, Pierre Giglio, Russell R Lonser, J Bradley Elder

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244383 (2020)

BackgroundCarboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high grade gliomas is poor due to limited penetration across the blood-brain barrier (BB

Externí odkaz: https://doaj.org/article/d53ef453fad44964bffeeb5c6f7a7ab6

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Akademický článek

Mechanisms of hearing loss in neurofibromatosis type 2.

Autor: Ashok R Asthagiri, Raul A Vasquez, John A Butman, Tianxia Wu, Keaton Morgan, Carmen C Brewer, Kelly King, Chris Zalewski, H Jeffrey Kim, Russell R Lonser

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46132 (2012)

Patients with neurofibromatosis type 2 (NF2) develop bilateral cochleovestibular schwannomas (CVSs) that cause binaural deafness in most individuals. Hearing loss occurs in an unpredictable manner and the underlying mechanisms are not known. To gain

Externí odkaz: https://doaj.org/article/ba1fac52652a4b41a108056a2dba078c

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Akademický článek

Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.

Autor: David S Xu, Chunzhang Yang, Martin Proescholdt, Elisabeth Bründl, Alexander Brawanski, Xueping Fang, Cheng S Lee, Robert J Weil, Zhengping Zhuang, Russell R Lonser

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37811 (2012)

Glioblastoma multiforme is the most common and malignant primary brain tumor. Recent evidence indicates that a subset of glioblastoma tumor cells have a stem cell like phenotype that underlies chemotherapy resistance and tumor recurrence. We utilized

Externí odkaz: https://doaj.org/article/f8f0f4d4c28444a38a21b48f01f0ebf3

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Akademický článek

Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers.

Autor: Ryszard M Pluta, Edward H Oldfield, Kamran D Bakhtian, Ali Reza Fathi, René K Smith, Hetty L Devroom, Masoud Nahavandi, Sukyung Woo, William D Figg, Russell R Lonser

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e14504 (2011)

Infusion of sodium nitrite could provide sustained therapeutic concentrations of nitric oxide (NO) for the treatment of a variety of vascular disorders. The study was developed to determine the safety and feasibility of prolonged sodium nitrite infus

Externí odkaz: https://doaj.org/article/2e8dfb1ad4184044abc6d1bf5564dd3d

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Akademický článek

Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains.

Autor: Andreas Androutsellis-Theotokis, Stuart Walbridge, Deric M Park, Russell R Lonser, Ronald D G McKay

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10841 (2010)

New mechanisms that regulate neural stem cell (NSC) expansion will contribute to improved assay systems and the emerging regenerative approach that targets endogenous stem cells. Expanding knowledge on the control of stem cell self renewal will also

Externí odkaz: https://doaj.org/article/3e347f6deaa748b0b3e46f8b6ba727a0

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Akademický článek

Angiogenic factors stimulate growth of adult neural stem cells.

Autor: Andreas Androutsellis-Theotokis, Maria A Rueger, Deric M Park, Justin D Boyd, Raji Padmanabhan, Loraine Campanati, Craig V Stewart, Yann LeFranc, Dietmar Plenz, Stuart Walbridge, Russell R Lonser, Ronald D G McKay

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9414 (2010)

The ability to grow a uniform cell type from the adult central nervous system (CNS) is valuable for developing cell therapies and new strategies for drug discovery. The adult mammalian brain is a source of neural stem cells (NSC) found in both neurog

Externí odkaz: https://doaj.org/article/0d236fde47db43fc807832f757dcfba8

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Akademický článek

von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells.

Autor: Deric M Park, Zhengping Zhuang, Ling Chen, Nicholas Szerlip, Irina Maric, Jie Li, Taesung Sohn, Stephanie H Kim, Irina A Lubensky, Alexander O Vortmeyer, Griffin P Rodgers, Edward H Oldfield, Russell R Lonser

Publikováno v: PLoS Medicine, Vol 4, Iss 2, p e60 (2007)

BACKGROUND: To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells fro

Externí odkaz: https://doaj.org/article/e930360105c74d679d4f7e92f0642a91

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