Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Russell P. Darst"'
Autor:
Eliza Morton, Hadley Browder, Kevin Kapadia, Carolina E. Pardo, Parker Knight, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Russell P. Darst, Rhonda Bacher
Publikováno v:
Bioinformatics
Summary Differential DNA methylation and chromatin accessibility are associated with disease development, particularly cancer. Methods that allow profiling of these epigenetic mechanisms in the same reaction and at the single-molecule or single-cell
Autor:
Tomoki Sunose, Michael P. Kladde, Kazuhiko Igarashi, Suming Huang, Jared R. Stees, Yasushi Kudo, Carolina E. Pardo, Mir A. Hossain, Nancy H. Nabilsi, Jörg Bungert, Russell P. Darst, Rosha Poudyal
Publikováno v:
Molecular and Cellular Biology. 36:238-250
Enhancers and promoters assemble protein complexes that ultimately regulate the recruitment and activity of RNA polymerases. Previous work has shown that at least some enhancers form stable protein complexes, leading to the formation of enhanceosomes
Autor:
Michael P. Kladde, Brent A. Reynolds, Alberto Riva, Russell P. Darst, Loic P. Deleyrolle, Nancy H. Nabilsi
Publikováno v:
Genome Research. 24:329-339
Human tumors are comprised of heterogeneous cell populations that display diverse molecular and phenotypic features. To examine the extent to which epigenetic differences contribute to intratumoral cellular heterogeneity, we have developed a high-thr
Autor:
Amber L. Delmas, Russell P. Darst, Erin M. Siegel, Eugene Izumchenko, Bridget Riggs, Lisa Dyer, Michael P. Kladde, Carolina E. Pardo, Mänette Monroe, Ardeshir Hakam, Kevin D. Brown
Publikováno v:
Carcinogenesis. 32:1625-1633
Aberrant activation of the Wnt/β-catenin signaling axis is a prominent oncogenic mechanism in numerous cancers including cervical cancer. Wnt inhibitory factor-1 (WIF1) is a secreted protein that binds Wnt and antagonizes Wnt activity. While the WIF
Autor:
Santhi Pondugula, M. Megan Reynolds, Daniel W. Neef, Archana Dhasarathy, Shinya Takahata, Russell P. Darst, Warren P. Voth, David J. Stillman, Michael P. Kladde
Publikováno v:
Molecular and Cellular Biology. 29:4891-4905
Cells devote considerable resources to nutrient homeostasis, involving nutrient surveillance, acquisition, and storage at physiologically relevant concentrations. Many Saccharomyces cerevisiae transcripts coding for proteins with nutrient uptake func
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1288
Chromatin limits the accessibility of DNA to trans-acting factors in transcription, replication, and repair. Although transcriptional variation between cells in a population may contribute to survival and disease, most assays of chromatin structure r
Publikováno v:
Methods in Molecular Biology ISBN: 9781493924738
Chromatin limits the accessibility of DNA to trans-acting factors in transcription, replication, and repair. Although transcriptional variation between cells in a population may contribute to survival and disease, most assays of chromatin structure r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4ff7b695449abab6ec190e965fc1aa
https://doi.org/10.1007/978-1-4939-2474-5_9
https://doi.org/10.1007/978-1-4939-2474-5_9
Publikováno v:
Proceedings of the National Academy of Sciences. 99:2666-2671
Mot1 is an essential yeast Snf2/Swi2-related ATPase that exerts both positive and negative effects on gene expression. In vitro , Mot1 can disrupt TATA-binding protein–DNA complexes in an ATP-dependent reaction. This activity can explain Mot1-media
Publikováno v:
Nucleic Acids Research
Spontaneous lytic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) occurs at a low rate in latently infected cells in disease and culture. This suggests imperfect epigenetic maintenance of viral transcription programs, perhaps due to va
A single-molecule probe of chromatin structure can uncover dynamic chromatin states and rare epigenetic variants of biological importance that bulk measures of chromatin structure miss. In bisulfite genomic sequencing, each sequenced clone records th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1842ab40487f90c21fe2af1222b59
https://europepmc.org/articles/PMC3697432/
https://europepmc.org/articles/PMC3697432/