Variant load of mitochondrial DNA in single human mesenchymal stem cells.

Autor: Hipps D; The Newcastle Upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK. daniel.hipps@nhs.net.; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. daniel.hipps@nhs.net., Pyle A; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Porter ALR; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Dobson PF; The Newcastle Upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK.; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Tuppen H; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lawless C; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Russell OM; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Turnbull DM; The Newcastle Upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK.; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Deehan DJ; The Newcastle Upon Tyne Hospitals NHS Foundation, Newcastle upon Tyne, UK., Hudson G; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. gavin.hudson@ncl.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 09; Vol. 14 (1), pp. 20989. Date of Electronic Publication: 2024 Sep 09.

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage.

Autor: Lambourne OA; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Bell S; Wellcome Centre for Mitochondrial Research, Newcastle University, Tyne NE2 4HH, U.K., Wilhelm LP; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee DD1 4HN, U.K., Yarbrough EB; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Holly GG; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Russell OM; Wellcome Centre for Mitochondrial Research, Newcastle University, Tyne NE2 4HH, U.K., Alghamdi AM; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Fdel AM; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Varricchio C; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Lane EL; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Ganley IG; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee DD1 4HN, U.K., Jones AT; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K., Goldberg MS; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Mehellou Y; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7645-7656. Date of Electronic Publication: 2023 May 29.

Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms.

Autor: Nolden KA; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Egner JM; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Collier JJ; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada., Russell OM; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK., Alston CL; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.; The National Health Service (NHS) Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Harwig MC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Widlansky ME; Department of Medicine, Division of Cardiovascular Medicine and Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI, USA., Sasorith S; Laboratoire de Génétique Moléculaire, Centre Hospitalier Universitaire and PhyMedExp, INSERM U1046, CNRS UMR 9214, Montpellier, France., Barbosa IA; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK., Douglas AG; Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Baptista J; Peninsula Medical School, Faculty of Health, University of Plymouth, Plymouth, UK., Walker M; Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Donnelly DE; Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, Belfast City Hospital, Belfast, UK., Morris AA; Willink Metabolic Unit, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Tan HJ; Department of Paediatric Neurology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Kurian MA; Developmental Neurosciences Department, Zayed Centre for Research into Rare Diseases in Children, University College London Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, UK., Gorman K; Department of Neurology and Clinical Neurophysiology, Children's Health Ireland at Temple Street, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., Mordekar S; Department of Paediatric Neurology, Sheffield Children's Hospital, Sheffield, UK., Deshpande C; Clinical Genetics Unit, Guys and St. Thomas' NHS Foundation Trust, London, UK., Samanta R; Department of Paediatric Neurology, University Hospitals Leicester NHS Trust, Leicester, UK., McFarland R; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.; The National Health Service (NHS) Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Hill RB; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.; The National Health Service (NHS) Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Oláhová M; Wellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK monika.olahova@ncl.ac.uk.

Publikováno v: Life science alliance [Life Sci Alliance] 2022 Aug 01; Vol. 5 (12). Date of Electronic Publication: 2022 Aug 01.

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

Autor: Smith AL; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Whitehall JC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Bradshaw C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gay D; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Robertson F; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Blain AP; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hudson G; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Pyle A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Houghton D; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hunt M; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sampson JN; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Stamp C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mallett G; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Amarnath S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Wilson L; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Baker A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Russell OM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Johnson R; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Richardson CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gupta B; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McCallum I; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McDonald SA; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kelly S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mathers JC; Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH., Heer R; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Perkins ND; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Turnbull DM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sansom OJ; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Greaves LC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Publikováno v: Nature cancer [Nat Cancer] 2020 Oct; Vol. 1 (10), pp. 976-989. Date of Electronic Publication: 2020 Sep 21.

Mitochondrial Diseases: Hope for the Future.

Autor: Russell OM; Wellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Clinical and Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Gorman GS; Wellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Clinical and Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NIHR Newcastle BRC, NuTH-NHS Foundation Trust, Newcastle upon Tyne NE4 5PL, UK., Lightowlers RN; Wellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: robert.lightowlers@newcastle.ac.uk., Turnbull DM; Wellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Clinical and Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: doug.turnbull@newcastle.ac.uk.

Publikováno v: Cell [Cell] 2020 Apr 02; Vol. 181 (1), pp. 168-188. Date of Electronic Publication: 2020 Mar 26.