Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Russell Naven"'
Autor:
Taisuke Katoh, Tomoya Sameshima, Masato Yoshikawa, Tomoya Yukawa, Hideto Hara, Takatoshi Yogo, Russell Naven, Makoto Miyamoto, Ikuo Miyahisa, Yoshihiko Hirozane, Teruaki Okuda
Publikováno v:
Chemical Research in Toxicology. 33:154-161
Despite the recent advances in the life sciences and the remarkable investment in drug discovery research, the success rate of small-molecule drug development remains low. Safety is the second most influential factor of drug attrition in clinical stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de95254694309472dcddfb7d08032ee3
https://doi.org/10.1021/acs.chemrestox.9b00128
https://doi.org/10.1021/acs.chemrestox.9b00128
Autor:
John Nicolette, Donald P. Quigley, Alejandra Trejo-Martin, David Woolley, Lidiya Stavitskaya, Lennart T. Anger, Dave Bower, Jennifer C. Sasaki, Candice Y. Johnson, Michelle O. Kenyon, Glenn J. Myatt, Sandy Weiner, Naomi L. Kruhlak, Susanne Glowienke, Véronique Gervais, Lisa Beilke, Angela White, Penny Leavitt, Roxanne Andaya, James Harvey, Joel P. Bercu, Andrew Teasdale, Jacky Van Gompel, Raymond Kemper, Kevin P. Cross, Scott Miller, Catrin Hasselgren, Barber Christopher Gordon, M. Vijayaraj Reddy, Joerg Wichard, Robert A. Jolly, Alessandro Brigo, Dennie S. Welch, Alexander Amberg, Russell Naven, Masamitsu Honma, Alexis Parenty, Stephen Gomez, Zoryanna Cammerer, Mark Powley, Laura Custer, Krista L. Dobo, Helga Gerets, Wolfgang Muster
Publikováno v:
Regulatory toxicology and pharmacology : RTP
The International Council for Harmonization (ICH) M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product. In the absence of adequate experimental bacterial mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc40f205a6b475a7fdd8889147e338e1
https://doi.org/10.1016/j.yrtph.2018.12.007
https://doi.org/10.1016/j.yrtph.2018.12.007
Autor:
Joel Bercu, Melisa J. Masuda Herrera, Alejandra Trejo-Martin, Catrin Hasselgren, Jean Lord, Jessica Graham, Matthew Schmitz, Lawrence Milchak, Colin Owens, Surya Hari Lal, Richard Marchese Robinson, Sarah Whalley, Phillip Bellion, Anna Vuorinen, Kamila Gromek, William A. Hawkins, Iris Van de Gevel, Kathleen Vriens, Raymond Kemper, Russell Naven, Pierre Ferrer, Glenn J. Myatt
Publikováno v:
Regulatory Toxicology and Pharmacology. 131:105165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7726cc1674d774d71e17faad1b039cea
https://doi.org/10.1016/j.yrtph.2022.105165
https://doi.org/10.1016/j.yrtph.2022.105165
Autor:
Colin Owens, Jessica C. Graham, Russell Naven, Glenn J. Myatt, Joel P. Bercu, Raymond Kemper, Iris van de Gevel, Surya Hari Lal, Kathleen Vriens, Melisa Masuda-Herrera, Phillip Bellion, Alejandra Trejo-Martin, Sarah Whalley, Lawrence Milchak, Richard L. Marchese Robinson, Anna Vuorinen, Catrin Hasselgren, Pierre Ferrer, William A. Hawkins, Matthew Schmitz, Kamila Gromek, Jean Lord
Publikováno v:
Regul Toxicol Pharmacol
This study assesses whether currently available acute oral toxicity (AOT) in silico models, provided by the widely employed Leadscope software, are fit-for-purpose for categorization and labelling of chemicals. As part of this study, a large data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964e311259d8ebd3de6475fb86827f15
https://pubmed.ncbi.nlm.nih.gov/35474000
https://pubmed.ncbi.nlm.nih.gov/35474000
Publikováno v:
Toxicology letters. 331
An important mechanism of chemical toxicity is the induction of oxidative stress through the production of excess reactive oxygen species (ROS). In this study, we show that the level of drug-induced ROS production between NRK52E and HepG2 cells is si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518166d320ce2dead9e196d51ea3c36a
https://pubmed.ncbi.nlm.nih.gov/32522578
https://pubmed.ncbi.nlm.nih.gov/32522578
Autor:
Amanda Giddings, James Harvey, Michael Kranz, Wolfgang Muster, Franck A. Atienzar, Susanne Glowienke, Krista L. Dobo, Helga Gerets, Lewis Whitehead, Magnus Wilhelm Walter, James Reuberson, Mukesh Patel, Mick D. Fellows, Joerg Wichard, Hans-Peter Spirkl, Michelle O. Kenyon, Steve Swallow, Jordi Munoz-Muriedas, Matt Selby, Alexander Amberg, Robert A. Jolly, Anne-Laure Werner, Andreas Sutter, Frank Bringezu, David J. Yeo, Russell Naven, Jacques Van Gompel
Publikováno v:
Computational Toxicology. 7:27-35
Primary aromatic amines (pAAs) are attractive building blocks in medicinal chemistry programmes yet their potential for mutagenic activity causes real concern owing to the risk of genotoxicity-related drug attrition. In addition, despite the existenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e54e6023b842ac8a6d60524200bd931
https://doi.org/10.1016/j.comtox.2018.06.002
https://doi.org/10.1016/j.comtox.2018.06.002
Autor:
Tomoya Yukawa, Russell Naven
Publikováno v:
ACS Med Chem Lett
[Image: see text] The role that physicochemical properties play toward increasing the likelihood of toxicity findings in in vivo studies has been well reported, albeit sometimes with different conclusions. We decided to understand the role that physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3233e61a1d87ba1b193ebfac548aa44
https://pubmed.ncbi.nlm.nih.gov/32071689
https://pubmed.ncbi.nlm.nih.gov/32071689
Autor:
Nigel, Greene, Russell, Naven
Publikováno v:
Current opinion in drug discoverydevelopment. 12(1)
Despite a steady increase in the total amount spent on pharmaceutical RD over the past decade, the number of new drug approvals has declined in recent years. Toxicity continues to account for more than 30% of compound attrition during the drug develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efea500b047168e9a5b7f930c31e4421
https://pubmed.ncbi.nlm.nih.gov/19152217
https://pubmed.ncbi.nlm.nih.gov/19152217