Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Russell N. Johnson"'
Autor:
Fabiola Giusti, Giulia Anderluzzi, Russell N. Johnson, Stuart Woods, Simona Gallorini, Barbara Baudner, Ilaria Ferlenghi, Signe Tandrup Schmidt, Derek T. O'Hagan, Gustavo Lou, Michela Brazzoli, Craig W. Roberts, Yvonne Perrie
Publikováno v:
Journal of Controlled Release
Self-amplifying RNA (SAM) represents a versatile tool that can be used to develop potent vaccines, potentially able to elicit strong antigen-specific humoral and cellular-mediated immune responses to virtually any infectious disease. To protect the S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b567326ac65ee6120b1309137f8b8c
https://pubmed.ncbi.nlm.nih.gov/32619745
https://pubmed.ncbi.nlm.nih.gov/32619745
Autor:
Jamie M. Bergen, Philip J. Horner, Russell N. Johnson, John Ravits, Heidi Back, Drew L. Sellers, Suzie H. Pun
Publikováno v:
Proceedings of the National Academy of Sciences. 113:2514-2519
A significant unmet need in treating neurodegenerative disease is effective methods for delivery of biologic drugs, such as peptides, proteins, or nucleic acids into the central nervous system (CNS). To date, there are no operative technologies for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5206612bf63d26087aa863619755dce
https://doi.org/10.1073/pnas.1515526113
https://doi.org/10.1073/pnas.1515526113
Publikováno v:
Biomaterials. 34:9632-9637
Targeted gene delivery vectors can enhance cellular specificity and transfection efficiency. We demonstrated previously that conjugation of Tet1, a peptide that binds to the GT1b ganglioside, to polyethylenimine results in preferential transfection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567c0f64f38b3de8d40a682c504cd476
https://doi.org/10.1016/j.biomaterials.2013.08.045
https://doi.org/10.1016/j.biomaterials.2013.08.045
Publikováno v:
International Journal of Pharmaceutics. 427:113-122
Biodegradability can be incorporated into cationic polymers via use of disulfide linkages that are degraded in the reducing environment of the cell cytosol. In this work, N -(2-hydroxypropyl)methacrylamide (HPMA) and methacrylamido-functionalized oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8156b00ff1dbb8320e387052c3c7c3
https://doi.org/10.1016/j.ijpharm.2011.08.015
https://doi.org/10.1016/j.ijpharm.2011.08.015
Publikováno v:
Biomacromolecules. 13:727-735
High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab’ fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab’ per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e15636e151f787df38c472a600420da
https://doi.org/10.1021/bm201656k
https://doi.org/10.1021/bm201656k
Autor:
Suzie H. Pun, Chung Huei K Wang, Julie Shi, David S.H. Chu, Joan G. Schellinger, Russell N. Johnson, Leslie W. Chan, André Lieber
Publikováno v:
Biomaterials. 32:9536-9545
Adenoviral (AdV) gene vectors offer efficient nucleic acid transfer into both dividing and non-dividing cells. However issues such as vector immunogenicity, toxicity and restricted transduction to receptor-expressing cells have prevented broad clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea63e6b32d7eaa38cbe0cdfb234f1c9
https://doi.org/10.1016/j.biomaterials.2011.08.069
https://doi.org/10.1016/j.biomaterials.2011.08.069
Publikováno v:
Angewandte Chemie International Edition. 49:1451-1455
A new paradigm was designed for apoptosis induction mediated by the biorecognition of coiled-coil motifs at the Raji B cell surface. The heterodimerization of complementary peptides, one bound to Fab’ antibody fragment, the other as grafts to HPMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bce7b3aa466f49986806c64915263fc
https://doi.org/10.1002/anie.200906232
https://doi.org/10.1002/anie.200906232
Publikováno v:
Bioconjugate Chemistry. 20:129-137
Several drug delivery designs combine synthetic drug carriers with covalently conjugated targeting moieties. Such modifications of monoclonal antibodies (mAb), or their Fab' fragments, inevitably result in diminished affinity for their targeted tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28213994b89edfc3d1d06f82934c1a75
https://doi.org/10.1021/bc800351m
https://doi.org/10.1021/bc800351m
Autor:
Brian Chou, Suzie H. Pun, Jennifer L. Choi, Russell N. Johnson, Julie Shi, Joan G. Schellinger
Publikováno v:
ACS nano. 7(12)
Nanoparticle morphology has been shown to affect cellular uptake, but there are few studies investigating the impact of particle shape on biologic drug delivery. Recently, our group synthesized a series of N-(2-hydroxypropyl) methacrylamide (HPMA)-ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7455b15f4b668cf227d8d9c1631b0c0c
https://pubmed.ncbi.nlm.nih.gov/24195594
https://pubmed.ncbi.nlm.nih.gov/24195594
Autor:
Joshuel A. Pahang, Russell N. Johnson, Suzie H. Pun, Anthony J. Convertine, Joan G. Schellinger, Patrick S. Stayton, Don O. Maris, Philip J. Horner, Drew L. Sellers, David S.H. Chu
Publikováno v:
Biomaterials. 34(9)
Non-viral gene delivery systems capable of transfecting cells in the brain are critical in realizing the potential impact of nucleic acid therapeutics for diseases of the central nervous system. In this study, the membrane-lytic peptide melittin was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56a84fbe830798459cbca0214e38396
https://pubmed.ncbi.nlm.nih.gov/23599916
https://pubmed.ncbi.nlm.nih.gov/23599916