Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Russell M. Howard"'
Autor:
Brandon L. Brown, Rachel M. Zalla, Courtney T. Shepard, Russell M. Howard, Jonathan A. Kopechek, David S. K. Magnuson, Scott R. Whittemore
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
The nervous system coordinates pathways and circuits to process sensory information and govern motor behaviors. Mapping these pathways is important to further understand the connectivity throughout the nervous system and is vital for developing treat
Externí odkaz:
https://doaj.org/article/cd7e30e544d84b4bac341798df207e48
Autor:
Sujata Saraswat Ohri, Kariena R. Andres, Russell M. Howard, Brandon L. Brown, Michael D. Forston, Michal Hetman, Scott R. Whittemore
Publikováno v:
Journal of Neurotrauma. 40:1007-1019
Autor:
Sujata, Saraswat Ohri, Kariena, Andres, Russell M, Howard, Brandon L, Brown, Michael D, Forston, Michal, Hetman, Scott R, Whittemore
Publikováno v:
Journal of neurotrauma.
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a major signal transducer of the endoplasmic reticulum stress response (ERSR) pathway. Outcomes of PERK activation range from abrogating ER stress to induction of cell death, dependen
Autor:
Scott R. Whittemore, Russell M. Howard, Michal Hetman, Kariena R. Andres, Courtney T Shepard, Sujata Saraswat Ohri, Yu Liu
Publikováno v:
Glia
The endoplasmic reticulum stress response (ERSR) is activated in various neurodegenerative diseases and/or after CNS traumatic injuries. The ERSR is comprised of three major arms, PERK, IRE-1, and activating transcription factor-6, with the latter tw
Autor:
S. Ashley Mullins, Scott R. Whittemore, Allison E. Smith, Andrew N. Bankston, Yu Liu, Kariena R. Andres, Amberly S. Riegler, Darlene A. Burke, Michal Hetman, Jason E. Beare, Russell M. Howard, Sujata Saraswat Ohri
Publikováno v:
The Journal of Neuroscience. 38:5900-5912
Autophagy mechanisms are well documented in neurons after spinal cord injury (SCI), but the direct functional role of autophagy in oligodendrocyte (OL) survival in SCI pathogenesis remains unknown. Autophagy is an evolutionary conserved lysosomal-med
Autor:
Scott R. Whittemore, Andrew N. Bankston, Nicholas J. Kuypers, Jason E. Beare, Russell M. Howard
Publikováno v:
The Journal of Neuroscience. 36:1698-1710
Oligodendrocyte (OL) loss contributes to the functional deficits underlying diseases with a demyelinating component. Remyelination by oligodendrocyte progenitor cells (OPCs) can restore these deficits. To understand the role that microRNAs (miRNAs) p
Autor:
Andrew N. Bankston, Michael D Forston, Allison E. Smith, Kariena R. Andres, Scott R. Whittemore, Russell M. Howard, Sujata Saraswat Ohri, Margaret L. Bates, Mary Bartlett Bunge
Publikováno v:
Glia. 67(9)
Deficient myelination, the spiral wrapping of highly specialized membrane around axons, causes severe neurological disorders. Maturation of oligodendrocyte progenitor cells (OPC) to myelinating oligodendrocytes (OL), the sole providers of central ner
Autor:
Rachel L. Hill, Scott R. Whittemore, Xiaoling Hu, Christopher B. Shields, Lisa B E Shields, Yiyan Zheng, Zhen Gu, Russell M. Howard, Xiao Ming Xu, Panpan Yu, Darlene A. Burke, Yi Ping Zhang
Publikováno v:
Experimental Neurology. 231:38-44
This study investigated whether neuronal inhibitor of DNA binding 2 (Id2), a regulator of basic helix-loop-helix (bHLH) transcription factors, can activate the intrinsic neuritogenetic mode of dorsal root ganglion (DRG) neurons in adult mice followin
Autor:
Scott R. Whittemore, Russell M. Howard, Richard L. Benton, John P. Woock, Gaby Enzmann, Pantelis Tsoulfas
Publikováno v:
Experimental Neurology. 195:293-304
Bone morphogenetic proteins (BMPs) are a large class of secreted factors, which serve as modulators of development in multiple organ systems, including the CNS. Studies investigating the potential of stem cell transplantation for restoration of funct
Publikováno v:
Experimental Neurology. 177:349-359
Differentiation of pluripotent neural stem cells engrafted into the adult normal and injured spinal cord is restricted to the glial lineage, suggesting that in vitro induction toward a neuronal lineage prior to transplantation and/or modification of