Výsledky vyhledávání - "Russell M. Dooling"

A Balancing Act between Net Uptake of Water during Dihydrofolate Binding and Net Release of Water upon NADPH Binding in R67 Dihydrofolate Reductase

Autor: Shaileja Chopra, Elizabeth E. Howell, Russell M. Dooling, Caroline Glyn Horner

Publikováno v: Journal of Biological Chemistry. 283:4690-4698

R67 dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor. This enzyme is a homotetramer possessing 222 symmetry, and a single active site pore traverses the length of the protein.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba275ce5fd5ffe8cd1ac5b250812d43
https://doi.org/10.1074/jbc.m709443200

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