Výsledky vyhledávání - "Russell L. Yeager"

Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone

Autor: Thomas A. Kost, J. Darren Stuart, Deborah Simpson Noel, Laurie K. Overton, Sue H. Kadwell, Timothy K. Tippin, H. Neal Bramson, Kenneth Batchelor, Russell L. Yeager, Christine R. Hoffman, Frank Lee

Publikováno v: Biochemical Pharmacology. 62:933-942

The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with 17beta-N-(2,5-bis(trifluoromethyl)phenyl)carbamoyl-4-aza-5alpha-androst-1-en-3-one (GI198745) was investigated at pH 7 and 37 degrees. This 5al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f86e8b2553057aa1154a62c9e57b7bd
https://doi.org/10.1016/s0006-2952(01)00728-6

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Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

Autor: David S. Wagner, Vishal Shah, J. Sigafoos, Russell L. Yeager, Steve Castellino, Gary D Bowers, Gary Boyle, Mark de Serres, Andrew D. Roberts, Mehul Dave, Claire Beaumont, Katie L Olson, Cosette J. Serabjit-Singh, Dipak K. Patel

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 41(6)

A model that predicts human metabolism and disposition of drug candidates would be of value in early drug development. In this study, a chimeric (uPA+/+)/SCID mouse model was evaluated with three structurally distinct compounds (GW695634, a benzophen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b867347211a6031ba99a038aebc58bb
https://pubmed.ncbi.nlm.nih.gov/21370990

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Sorption/desorption of [14C]efrotomycin with soils

Autor: Russell L. Yeager, Bruce A. Halley

Publikováno v: Journal of Agricultural and Food Chemistry. 38:883-886

The sorption and subsequent desorption of efrotomycin, which is being developed as a growth promoter in swine, was investigated in five soils of various physical and chemical properties. Sorption equilibration occurred within 7 h. Sorption distributi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b96da53747b458664a269b3a26531d7a
https://doi.org/10.1021/jf00093a062

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The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia

Autor: Beth Case, John E. Dillberger, Mark de Serres, Marlene L. Hauck, Anita H. Simkins, Russell L. Yeager, Virginia D. Schmith, Rodney L. Page

Publikováno v: Stem cells (Dayton, Ohio). 18(5)

GW395058, a PEGylated peptide agonist of the thrombopoietin receptor, stimulates megakaryocytopoiesis and has previously been shown to increase platelet counts in vivo. The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c750d8ed0c6e22e437b4eda57733dca8
https://pubmed.ncbi.nlm.nih.gov/11007920

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Systemic bioavailability and pharmacokinetics of methylprednisolone in patients with rheumatoid arthritis following ‘high-dose’ pulse administration

Autor: Dulal C. Chatterji, Prem K. Narang, R. Wilder, Russell L. Yeager, Joseph F. Gallelli

Publikováno v: Biopharmaceutics & Drug Disposition. 4:233-248

The absolute and relative bioavailability of two methylprednisolone formulations (capsules and suspension) was determined along with its pharmacokinetics in four arthritic female patients, following an unconventional high-dose pulse of 1 g. Plasma co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edc43c757e77094e161572e890392b0
https://doi.org/10.1002/bdd.2510040305

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Quantitation of testolactone and 4,5-dihydrotestolactone in plasma and urine using high-performance liquid chromatography

Autor: R.V. Clark, Dulal C. Chatterji, R.J. Sherins, Russell L. Yeager, V.L. Pascucci, Joseph F. Gallelli

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 277:79-85

A rapid, sensitive, and selective assay is described for the quantitation of both testolactone and its recently identified metabolite, 4,5-dihydrotestolactone, in plasma and urine using high-performance liquid chromatography. The procedure includes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f12ca5e0c772517442a41f01f50ddd3
https://doi.org/10.1016/s0378-4347(00)84825-2

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Rapid GC method for quantitation of nifedipine in serum using electron capture detection

Autor: Dulal C. Chatterji, Russell L. Yeager, Ann K. Miller, Lawrence J. Lesko

Publikováno v: Journal of chromatographic science. 21(9)

For studying the pharmacokinetics of nifedipine after single doses, a rapid, specific, reliable gas chromatographic assay procedure for nifedipine in serum is developed. Using a single-step solvent extraction or a bonded-phase column extraction and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b703b280af194709fda33029f86e93
https://pubmed.ncbi.nlm.nih.gov/6630401

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Kinetics of chlorambucil hydrolysis using high-pressure liquid chromatography

Autor: Dulal C. Chatterji, Joseph F. Gallelli, Russell L. Yeager

Publikováno v: Journal of pharmaceutical sciences. 71(1)

A stability-specific high-pressure liquid chromatographic (HPLC) method was developed to assay intact chlorambucil (I) in the presence of its hydrolytic decomposition products. The HPLC method was used to follow the degradation kinetics of I over pH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee26423424fe8afc025c367dfe88af9
https://pubmed.ncbi.nlm.nih.gov/7057380

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