Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Russell James Sheldon"'
Autor:
Julie A. Farmer, Adrian Gregory Switzer, Martin E. Dowty, Timothy B. Field, Adam W. Mazur, Xinrong Tian, Russell James Sheldon, Beth B. Pinney, Steve Berberich, Lalith R. Jayasinghe, Frank H. Ebetino, Doreen Crossdoersen, John August Wos, Cindy Obringer
Publikováno v:
Journal of Medicinal Chemistry. 49:4745-4761
The design, synthesis, and structure-activity relationships (SAR) of a series of novel proline and pyrrolidine based melanocortin receptor (MCR) agonists are described. To validate a conformationally constrained Arg-Nal dipeptide analogue strategy, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c13dd0d81d8232511803d1ceb5b3a8d
https://doi.org/10.1021/jm060384p
https://doi.org/10.1021/jm060384p
Autor:
Beth B. Pinney, Jeffery C. Hayes, Xinrong Tian, Russell James Sheldon, Mark Gregory Solinsky, Adrian Gregory Switzer, Frank H. Ebetino, Doreen Crossdoersen, John August Wos, Julie A. Farmer, Xuemei Chen, Lixian Gan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1721-1725
The first synthesis of Tic-D-Phe Psi[CH(2)-CH(2)] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f2e272b4df8d3a15260f691f187f61
https://doi.org/10.1016/j.bmcl.2005.12.005
https://doi.org/10.1016/j.bmcl.2005.12.005
Autor:
Russell James Sheldon, Frank H. Ebetino, Doreen Crossdoersen, Beth B. Pinney, Timothy B. Field, John August Wos, Adam W. Mazur, Xinrong Tian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2819-2823
A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d98be2223eb0fbcce5b4ccf24d34b93
https://doi.org/10.1016/j.bmcl.2005.03.120
https://doi.org/10.1016/j.bmcl.2005.03.120
Autor:
Jana S. Lange, Richard T. Hinkle, Elizabeth Donnelly, Eric Tobar, Russell James Sheldon, Sarah C. Coste, Steven Samuelsson, Robert J. Isfort, Mark A. Tarnopolsky, Mary Beth Bauer, David B. Cody, Mary P. Stenzel-Poore
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 285:E889-E898
Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba074f43444c9afb1d59e347adc404d
https://doi.org/10.1152/ajpendo.00081.2003
https://doi.org/10.1152/ajpendo.00081.2003
Autor:
Randy J. Seeley, Patrick Messerschmidt, Stephen C. Woods, Dawn M.M Eckstein, Karen M.B. Hodge, Charles C. McOsker, Kihmberly A. Wilmer, Russell James Sheldon, Melissa B. Jones, Stephen C. Benoit, Ellen L. Air
Publikováno v:
Physiology & Behavior. 79:761-766
The conditioned taste aversion (CTA) is routinely used to assess the aversive consequences of anorexic agents, including potential pharmacological therapies for obesity. In a typical CTA paradigm, rats briefly sampling a novel tastant (e.g., sacchari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b1923a164753c7e70afb3c6b40310
https://doi.org/10.1016/s0031-9384(03)00189-6
https://doi.org/10.1016/s0031-9384(03)00189-6
Autor:
Karen M.B. Hodge, Kihmberly A. Wilmer, Stephen C. Woods, Randy J. Seeley, Charles C. McOsker, P Messerschmidt, Ellen L. Air, Stephen C. Benoit, Melissa B. Jones, Russell James Sheldon, D M M Eckstein
Publikováno v:
International Journal of Obesity. 27:550-556
BACKGROUND: The synthetic melanocortin (MC) agonist, melanotan-II (MTII), reduces food intake and body weight for hours to days after administration. One early report on the effect of MTII suggested that part of its anorexic action may be mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec892f114f3f3ece95e499f9cc75dcc
https://doi.org/10.1038/sj.ijo.0802280
https://doi.org/10.1038/sj.ijo.0802280
Autor:
Melissa B. Jones, Russell James Sheldon, N. Leigh Anderson, Thomas Keough, Richard T. Hinkle, Feng Wang, Robert J. Isfort, Yiping Sun, Kenneth D. Greis
Publikováno v:
Electrophoresis. 21:2228-2234
A proteomic analysis was performed comparing normal rat soleus muscle to denervated soleus muscle at 0.5, 1, 2, 4, 6, 8 and 10 days post denervation. Muscle mass measurements demonstrated that the times of major mass changes occurred between 2 and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39241fa8a591a67ccbb4a80fbaed2060
https://doi.org/10.1002/1522-2683(20000601)21:11<2228::aid-elps2228>3.0.co
https://doi.org/10.1002/1522-2683(20000601)21:11<2228::aid-elps2228>3.0.co
Autor:
Frank H. Ebetino, Doreen Crossdoersen, Lily Dong, Mark E. Webster, Beth B. Pinney, Russell James Sheldon, Adrian Gregory Switzer, Cindy Obringer, Mumin Rashid Naeem, Lalith R. Jayasinghe, Anny-Odile Colson, Rajesh K. Mishra, Charles A. Cruze, John August Wos, Steve A. Derose, Mark Gregory Solinsky, Martin E. Dowty, Paula M. Suchanek, Xinrong Tian, Julie A. Farmer, Melissa L. Burklow, Mary Kay Dirr
Publikováno v:
Journal of medicinal chemistry. 51(19)
A study that was designed to identify plausible replacements for highly basic guanidine moiety contained in potent MC4R agonists, as exemplified by 1, led to the discovery of initial nonguanidine lead 5. Propyl analog 23 was subsequently found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e52a7fe340a9c83c2c7be10d428b58
https://pubmed.ncbi.nlm.nih.gov/18771254
https://pubmed.ncbi.nlm.nih.gov/18771254
Autor:
Adam W. Mazur, Russell James Sheldon, Nick K. Kim, Julie A. Farmer, Xinrong Tian, John August Wos, Frank H. Ebetino, Doreen Crossdoersen, X. Eric Hu, Adrian Gregory Switzer, Rajesh K. Mishra, Beth B. Pinney
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(17)
The design and synthesis of a series of potent 1,3,4-trisubstituted-2-oxopiperazine based MC4 agonists are described. The tripeptidomimetic analogs (12a,b and 23) and the dipeptidomimetic 27 displayed single-nanomolar binding affinity and agonist pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4afe7785f394889d87bf23f1b6b7cc9
https://pubmed.ncbi.nlm.nih.gov/16766182
https://pubmed.ncbi.nlm.nih.gov/16766182
Autor:
Ofer Reizes, Russell James Sheldon, Melissa L. Burklow, Randy J. Seeley, Maria Claudia Gross, Darren Paul Trokhan, Colette C. Matthews, Kihmberly A. Wilmer, Charles C. McOsker
Publikováno v:
Endocrinology. 146(9)
A wide range of experimental evidence implicates a critical role for melanocortin signaling in the control of food intake and body adiposity. Melanocortin receptor agonists such as MT-II potently reduce food intake and body weight, making such agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6504baa913fbc2c81f734796b7f3f9
https://pubmed.ncbi.nlm.nih.gov/15932932
https://pubmed.ncbi.nlm.nih.gov/15932932