Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Russell J Bonaguro"'
Autor:
Jack W Hickmott, Chih-yu Chen, David J Arenillas, Andrea J Korecki, Siu Ling Lam, Laurie L Molday, Russell J Bonaguro, Michelle Zhou, Alice Y Chou, Anthony Mathelier, Sanford L Boye, William W Hauswirth, Robert S Molday, Wyeth W Wasserman, Elizabeth M Simpson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Current gene therapies predominantly use small, strong, and readily available ubiquitous promoters. However, as the field matures, the availability of small, cell-specific promoters would be greatly beneficial. Here we design seven small promoters fr
Externí odkaz:
https://doaj.org/article/ec3b5f27a8ba4237bd6536d98ddff289
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002544 (2012)
An increasing body of literature from genome-wide association studies and human whole-genome sequencing highlights the identification of large numbers of candidate regulatory variants of potential therapeutic interest in numerous diseases. Our relati
Externí odkaz:
https://doaj.org/article/233a496debe64c12aad436a8d36af29b
Autor:
Lisa Dreolini, Oliver Baker, Robert A. Holt, Jan M. Deussing, Chin-Vern Tan, Anthony Mathelier, Wyeth W. Wasserman, Jack W. Hickmott, A. Francis Stewart, Claudia Kuehne, Russell J. Bonaguro, Michelle Zhou, Elizabeth M. Simpson, Siu Ling Lam, Jillian Smith, Andrea J. Korecki, Dan Goldowitz
Publikováno v:
Genetics
To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afcd0bd1185075d280624d22144ab5e
https://doi.org/10.1534/genetics.119.301984
https://doi.org/10.1534/genetics.119.301984
Autor:
Lori Tucker, Ian Pike, Jennifer S. Smith, Shazhan Amed, Louise C. Mâsse, Russell J. Bonaguro, Dawn Mount, Janet W. T. Mah, Stephanie M. N. Glegg, Mariana Brussoni, Ainsley M. Boudreau
Publikováno v:
BMJ Open
ObjectivesThe objective of this study was to explore parent perspectives of and interest in an interactive knowledge translation platform called Child-Sized KT that proposes to catalyse the collaboration of patients, families, practitioners and resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049882708ff703de823ce9e7205c5cba
https://pubmed.ncbi.nlm.nih.gov/31154301
https://pubmed.ncbi.nlm.nih.gov/31154301
Autor:
Stéphanie Laprise, Alice Y Chou, Aravind Asokan, Elodie Portales-Casamar, Wyeth W. Wasserman, Lisa J. Borretta, Vikramjit Chopra, Olga Kaspieva, George S. Yang, Dan Goldowitz, Cletus D'Souza, Elizabeth M. Simpson, Robert A. Holt, Magdalena I. Swanson-Newman, Michelle Zhou, Siu Ling Lam, Kaelan Wong, Andrea J. Korecki, Jack W. Hickmott, Simone C McInerny, Russell J. Bonaguro, Tess C Lengyell, Garrett E. Berry, Steven J.M. Jones, Charles N. de Leeuw
Publikováno v:
Molecular Brain
Background: Small promoters that recapitulate endogenous gene expression patterns are important for basic, preclinical, and now clinical research. Recently, there has been a promising revival of gene therapy for diseases with unmet therapeutic needs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cfa6eab0b5067556b82bc274888153
Autor:
Brett S. Abrahams, Douglas Blackwood, Kevin A. McGhee, Rosalia Aguirre-Hernandez, Ravinesh A. Kumar, Emil F. Coccaro, Gustavo Turecki, Angela Brooks-Wilson, Stephen Leach, Alan W Maclean, Russell J. Bonaguro, Anne Condon, Walter J. Muir, Sheilagh Hodgins, Elizabeth M. Simpson
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :880-889
Nuclear receptor 2E1 gene (NR2E1) resides within a 6q21-22 locus for bipolar disorder and schizophrenia. Mice deleted for Nr2e1 show altered neurogenesis, cortical and limbic abnormalities, aggression, hyperexcitability, and cognitive impairment. NR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ab0bbbc036d5d89a95ef5ab371cf93
https://doi.org/10.1002/ajmg.b.30696
https://doi.org/10.1002/ajmg.b.30696
Autor:
Slavita Bohacec, Russell J. Bonaguro, David J. Arenillas, Steven J.M. Jones, Siaw H. Wong, Jean-François Schmouth, Elizabeth M. Simpson, Kathleen G. Banks, Marco A. Marra, Wyeth W. Wasserman, Yuanyun Xie, Ximena Corso-Díaz
Publikováno v:
BMC Genomics
Background Nr2e1 (nuclear receptor subfamily 2, group e, member 1) encodes a transcription factor important in neocortex development. Previous work has shown that nuclear receptors can have hundreds of target genes, and bind more than 300 co-interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b030431bc44c5582b517360b55b9bb9e
https://doi.org/10.1186/s12864-015-1770-3
https://doi.org/10.1186/s12864-015-1770-3
Autor:
Alice Y Chou, William W. Hauswirth, Robert S. Molday, Anthony Mathelier, Jack W. Hickmott, Chih-Yu Chen, David J. Arenillas, Wyeth W. Wasserman, Siu Ling Lam, Sanford L. Boye, Russell J. Bonaguro, Michelle Zhou, Elizabeth M. Simpson, Andrea J. Korecki, Laurie L. Molday
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Current gene therapies predominantly use small, strong, and readily available ubiquitous promoters. However, as the field matures, the availability of small, cell-specific promoters would be greatly beneficial. Here we design seven small promoters fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0dfb75ad665e20e6130fdfed90f88
https://doi.org/10.1038/mtm.2016.51
https://doi.org/10.1038/mtm.2016.51
Autor:
Bibiana K. Y. Wong, Randy Glenn, Cletus D'Souza, Vik Chopra, Magdalena I. Swanson, Meifen Lu, Flora Liu, Douglas J. Swanson, Marko Milisavljevic, Diana L. Palmquist, Taryn G. Hearty, Jenna L. Turner, Jonathan S. Lim, Steven J.M. Jones, Debra L. Fulton, Erin K. Flynn, Wyeth W. Wasserman, Dan Goldowitz, Betty Palma, Sonia F. Black, David J. Arenillas, Steven Jiang, Jing M. Chen, Charles N. de Leeuw, Russell J. Bonaguro, Stéphanie Laprise, Kathleen G. Banks, Athena R. Ypsilanti, Jacek Mis, Mahsa Amirabbasi, Ivana Komljenovic, Katie O’Connor, Robert A. Holt, Nancy Y. Liao, Ying Chen, Russell F. Watkins, Stuart Lithwick, Shannan J. Ho Sui, Elodie Portales-Casamar, Richard Varhol, Bonny Tam, Jun Liu, Li Liu, Lisa Dreolini, Mauro Castellarin, Andrea J. McLeod, Amy Ticoll, Nazar Babyak, Kristi Hatakka, Elizabeth M. Simpson, Jason C. Y. Cheng, Gary M. Wilson, Siaw H. Wong, Erich Brauer, Jean-François Schmouth, Behzad Imanian, Melissa K. McConechy, Johar Ali, Shadi Khorasan-zadeh, Jenny Vermeulen, T. Roderick Docking, George S. Yang, Tony Wong, Tara Candido
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(38)
The Pleiades Promoter Project integrates genomewide bioinformatics with large-scale knockin mouse production and histological examination of expression patterns to develop MiniPromoters and related tools designed to study and treat the brain by direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b311c1674c9c1ac3c1eb5e4433c1a2d
https://pubmed.ncbi.nlm.nih.gov/21049577
https://pubmed.ncbi.nlm.nih.gov/21049577
Autor:
Russell J. Bonaguro, George S. Yang, L. Liu, C.N. de Leeuw, Douglas J. Swanson, Gary M. Wilson, Dan Goldowitz, Robert A. Holt, Lisa Dreolini, Kathleen G. Banks, Elizabeth M. Simpson
Publikováno v:
Genomics. 93(3)
We have engineered a set of useful tools that facilitate targeted single copy knock-in (KI) at the hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) locus. We employed fine scale mapping to delineate the precise breakpoint location at the Hpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b9578410b1f25c78b1a9dcd9107f51
https://pubmed.ncbi.nlm.nih.gov/18950699
https://pubmed.ncbi.nlm.nih.gov/18950699