Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Russell J, Wiese"'
Autor:
Stephen J. Nicholls, Santiago Tofé, Carel W. le Roux, David A. D’Alessio, Russell J. Wiese, Imre Pavo, Katelyn Brown, Govinda J. Weerakkody, Meltem Zeytinoglu, Irene C. Romera
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background Metabolic syndrome is characterized as the co-occurrence of interrelated cardiovascular risk factors, including insulin resistance, hyperinsulinemia, abdominal obesity, dyslipidemia and hypertension. Once weekly tirzepatide is app
Externí odkaz:
https://doaj.org/article/fe7b1924c64f4aba90d45911656869ae
Autor:
Naveed Sattar, Darren K. McGuire, Imre Pavo, Govinda J. Weerakkody, Hiroshi Nishiyama, Russell J. Wiese, Sophia Zoungas
Publikováno v:
Nature Medicine. 28:591-598
Tirzepatide is a novel, once weekly, dual GIP/GLP-1 receptor agonist and is under development for the treatment of type 2 diabetes (T2D) and obesity. Its association with cardiovascular outcomes requires evaluation. This pre-specified cardiovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da407cd0e915cf8f1ff1d4ea415073e
https://doi.org/10.1038/s41591-022-01707-4
https://doi.org/10.1038/s41591-022-01707-4
Autor:
Hiddo J L, Heerspink, Naveed, Sattar, Imre, Pavo, Axel, Haupt, Kevin L, Duffin, Zhengyu, Yang, Russell J, Wiese, Katherine R, Tuttle, David Z I, Cherney
Publikováno v:
The Lancet Diabetes and Endocrinology, 10(11), 774-785. ELSEVIER SCIENCE INC
Background: In the SURPASS-4 trial, the dual GIP and GLP-1 receptor agonist tirzepatide reduced HbA1c concentrations, bodyweight, and blood pressure more than titrated daily insulin glargine in people with type 2 diabetes inadequately controlled on o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e32ba5e7ec793343b56a3763241de9
https://research.rug.nl/en/publications/9fd182d5-8590-4916-a1a3-8301509299bf
https://research.rug.nl/en/publications/9fd182d5-8590-4916-a1a3-8301509299bf
Autor:
Stefano Del Prato, Steven E. Kahn, Imre Pavo, Govinda J. Weerakkody, Zhengyu Yang, John Doupis, Diego Aizenberg, Alan G. Wynne, Jeffrey S. Riesmeyer, Robert J. Heine, Russell J. Wiese, Jochen Seufert
Publikováno v:
Hand in Hand zum Ziel – einfach.besser.messbar www.diabeteskongress.de.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582f578caf1151b44007a4bd05d2946a
https://doi.org/10.1055/s-0042-1746267
https://doi.org/10.1055/s-0042-1746267
Autor:
Naveed, Sattar, Darren K, McGuire, Imre, Pavo, Govinda J, Weerakkody, Hiroshi, Nishiyama, Russell J, Wiese, Sophia, Zoungas
Publikováno v:
Nature medicine. 28(3)
Tirzepatide is a novel, once weekly, dual GIP/GLP-1 receptor agonist and is under development for the treatment of type 2 diabetes (T2D) and obesity. Its association with cardiovascular outcomes requires evaluation. This pre-specified cardiovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28177ebb88e5595df01e980fe2ec01c2
https://pubmed.ncbi.nlm.nih.gov/35260841
https://pubmed.ncbi.nlm.nih.gov/35260841
Autor:
Orlando F. Bueno, Bruce E. Markham, Russell J. Wiese, Yan-Shan Dai, Jeffery D. Molkentin, Qiangrong Liang
Publikováno v:
Molecular and Cellular Biology. 21:7460-7469
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1439e783aed20a3dcd10411176fd27b9
https://doi.org/10.1128/mcb.21.21.7460-7469.2001
https://doi.org/10.1128/mcb.21.21.7460-7469.2001
Autor:
Keishi Yamauchi, Cynthia Corley Mastick, Jeffrey E. Pessin, Pedro Cuatrecasas, Matthew J. Brady, Steven B. Waters, Russell J. Wiese, Dan F. Lazar, Alan R. Saltiel
Publikováno v:
Journal of Biological Chemistry. 270:20801-20807
Insulin stimulates the activity of mitogen-activated protein kinase (MAPK) via its upstream activator, MAPK kinase (MEK), a dual specificity kinase that phosphorylates MAPK on threonine and tyrosine. The potential role of MAPK activation in insulin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49fa5adc5ed5c7753953f95b63c5374
https://doi.org/10.1074/jbc.270.35.20801
https://doi.org/10.1074/jbc.270.35.20801
Publikováno v:
Scopus-Elsevier
Activation of the tyrosine kinase activity of the insulin receptor by autophosphorylation leads to phosphorylation of cellular substrates on tyrosine. Thus far, the best characterized is the insulin receptor substrate (IRS) 1, which has been proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfffde69461040dc7b791f090abe0d2
https://doi.org/10.1042/bj3080579
https://doi.org/10.1042/bj3080579
Autor:
Stephen J. Marx, Jean M. Prahl, Hector F. DeLuca, Hitoshi Goto, Aida Al-Aqeel, Monique Thomas, Russell J. Wiese
Publikováno v:
Molecular and Cellular Endocrinology. 90:197-201
Fibroblasts from three patients with vitamin D-dependency rickets type II were used to study mutations in the 1,25-dihydroxyvitamin D 3 receptor responsible for this hereditary disease. Normal human fibroblasts contain 43 ± 13 fmol receptor/mg prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611c36977013c0edba1318752b297788
https://doi.org/10.1016/0303-7207(93)90152-a
https://doi.org/10.1016/0303-7207(93)90152-a
Publikováno v:
Journal of Biological Chemistry. 267:20082-20086
Several studies have shown that the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) receptor protein levels increase in response to 1,25-(OH)2D3. We have studied the mechanism of this regulation in both mouse fibroblasts and rat intestinal epithelial cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba09792660485ad9043645f20f3f1a12
https://doi.org/10.1016/s0021-9258(19)88668-4
https://doi.org/10.1016/s0021-9258(19)88668-4