Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Russell J, Cox"'
Autor:
Sabrina Collin, Russell J. Cox, Cédric Paris, Christophe Jacob, Benjamin Chagot, Kira J. Weissman, Arnaud Gruez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Biosynthesis of complex polyketides by polyketide synthases often relies on trans-acting enzymes to modify the intermediates. Here, the authors elucidate how β-methylation enzymes identify their substrates. The recognition is imperfect, resulting in
Externí odkaz:
https://doaj.org/article/277ce5ce2daf472f98faa92625d7d1ad
Autor:
Ole Christian Hagestad, Lingwei Hou, Jeanette H. Andersen, Espen H. Hansen, Bjørn Altermark, Chun Li, Eric Kuhnert, Russell J. Cox, Pedro W. Crous, Joseph W. Spatafora, Kathleen Lail, Mojgan Amirebrahimi, Anna Lipzen, Jasmyn Pangilinan, William Andreopoulos, Richard D. Hayes, Vivian Ng, Igor V. Grigoriev, Stephen A. Jackson, Thomas D. S. Sutton, Alan D. W. Dobson, Teppo Rämä
Publikováno v:
IMA Fungus, Vol 12, Iss 1, Pp 1-23 (2021)
ABSTRACT Marine fungi remain poorly covered in global genome sequencing campaigns; the 1000 fungal genomes (1KFG) project attempts to shed light on the diversity, ecology and potential industrial use of overlooked and poorly resolved fungal taxa. Thi
Externí odkaz:
https://doaj.org/article/2d4678d8f908489583a2e1a111df6ec7
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
A chemical investigation on the kiwi endophytic fungus Bipolaris sp. Resulted in the isolation of eight new terpenoids (1–8) and five known analogues (9–13). Compounds 1–5 are novel sativene sesquiterpenoids containing three additional skeletal
Externí odkaz:
https://doaj.org/article/d0cbd25397414449add275983c7f7935
Autor:
Lei Li, Russell J. Cox
Publikováno v:
Journal of Fungi, Vol 8, Iss 9, p 929 (2022)
This review summarises the known structures, biological activities, and biosynthetic pathways of the tropolone sesquiterpenoid family of fungal secondary metabolites. Synthesis of this knowledge allows likely structural and stereochemical misassignme
Externí odkaz:
https://doaj.org/article/a50428818a0845cd9c4101c95b7ec0da
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 355 (2022)
Trichoderma reesei (Hypocrea jecorina) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rap
Externí odkaz:
https://doaj.org/article/c15ec1a86dbd47999dd014647db6ffd8
Autor:
Risa Nofiani, Kate de Mattos-Shipley, Karen E. Lebe, Li-Chen Han, Zafar Iqbal, Andrew M. Bailey, Christine L. Willis, Thomas J. Simpson, Russell J. Cox
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Strobilurins are fungal metabolites that inspired the creation of β-methoxyacrylate agricultural fungicides. Here, Nofiani et al. identify the strobilurin biosynthesis gene cluster, encoding a polyketide synthase as well as an FAD-dependent oxygenas
Externí odkaz:
https://doaj.org/article/71b50d3e4230482bbedb9a03d418d152
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Xenovulene A is a fungal compound that has the potential to be used as an antidepressant. Here, the authors unravel the pathway leading to its formation in fungi and discover a new class of enzymes, which accounts for some unusual chemistry in the sy
Externí odkaz:
https://doaj.org/article/16116d69ae93478dab8aee6bc00fca48
Publikováno v:
Journal of Fungi, Vol 7, Iss 12, p 1034 (2021)
The trili biosynthetic gene cluster (BGC) from the well-studied organism Trichoderma reesei was studied by heterologous expression in the fungal host Aspergillus oryzae. Coexpression of triliA and triliB produces two new acyl tetramic acids. Addition
Externí odkaz:
https://doaj.org/article/ff5884aa8fd14ed3b3e7d3d17475e08e
Publikováno v:
Journal of Fungi, Vol 7, Iss 12, p 1085 (2021)
Microbial natural products have had phenomenal success in drug discovery and development yet form distinct classes based on the origin of their native producer. Methods that enable metabolic engineers to combine the most useful features of the differ
Externí odkaz:
https://doaj.org/article/707949a162434bf6adf3aa79931b3919
Publikováno v:
Organic & Biomolecular Chemistry. 20:7278-7283
Antroxazole A is a novel chamigrane dimer featuring with a dihydrooxazole moiety from Antrodiella albocinnamomea. It inhibits LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 μM.