Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Russell I. Ludowyke"'
Publikováno v:
Neurotoxicity Research. 35:969-980
We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis (ALS). ALS is the most common form of motor neuron disease (MND) in adults. It is a progressive and fatal disease. Approximately 90%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51f7d8840ff9fc72fa3104058fc5b58
https://doi.org/10.1007/s12640-018-9980-5
https://doi.org/10.1007/s12640-018-9980-5
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 14, Iss 9, Pp 1490-1493 (2019)
Neural Regeneration Research, Vol 14, Iss 9, Pp 1490-1493 (2019)
Fungi are important infectious disease-causing agents, but are often overlooked as environmental factors in disease. We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis (ALS), the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322d7723ef7daf6d26e0c9fde6d72860
https://doi.org/10.4103/1673-5374.255959
https://doi.org/10.4103/1673-5374.255959
Autor:
Helen Carpenter, Jeff Holst, Russell I. Ludowyke, Nicole M. Verrills, Alistair T. R. Sim, Lauren F. Watt, Stefan Strack, Gregory Kranias
Publikováno v:
Cellular Signalling. 22:1882-1890
Asthma is characterised by antigen-mediated mast cell degranulation resulting in secretion of inflammatory mediators. Protein phosphatase 2A (PP2A) is a serine/threonine protein phosphatase composed of a catalytic (PP2A-C) subunit together with a cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf0a923f9984859f516b935a4fb9b06
https://doi.org/10.1016/j.cellsig.2010.07.017
https://doi.org/10.1016/j.cellsig.2010.07.017
Autor:
Russell I. Ludowyke, Tanya Kranenburg, Justine R. Stehn, Carsten Schmitz-Peiffer, William E. Hughes, Zehra Elgundi, Trevor J. Biden
Publikováno v:
The Journal of Immunology. 177:1492-1499
Dynamic remodeling of the actinomyosin cytoskeleton is integral to many biological processes. It is regulated, in part, by myosin phosphorylation. Nonmuscle myosin H chain IIA is phosphorylated by protein kinase C (PKC) on Ser1917. Our aim was to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294913823bb8ee424ab11cf9c1e15b6b
https://doi.org/10.4049/jimmunol.177.3.1492
https://doi.org/10.4049/jimmunol.177.3.1492
Publikováno v:
Molecular Biology of the Cell. 13:1083-1098
Mast cells undergo cytoskeletal restructuring to allow secretory granules passage through the cortical actomyosin barrier to fuse with the plasma membrane and release inflammatory mediators. Protein phosphorylation is believed to regulate these rearr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd6e89bf13ff1a506e193071ae2d18b
https://doi.org/10.1091/mbc.01-12-0587
https://doi.org/10.1091/mbc.01-12-0587
Publikováno v:
FEBS Letters. 492:101-106
The study addressed the functional link between remodelling of the actomyosin cytoskeleton in pancreatic β-cells and the regulation of insulin secretion. Confocal microscopy revealed that myosin heavy chain (MHC) IIA co-localized very well with fila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d06e5289ea3608ca90d9aefafb0552c
https://doi.org/10.1016/s0014-5793(01)02241-4
https://doi.org/10.1016/s0014-5793(01)02241-4
Publikováno v:
Journal of Biological Chemistry. 275:6144-6152
Okadaic acid inhibits secretion from mast cells, suggesting a regulatory role for protein Ser/Thr phosphatases type I (PP1) and/or 2A (PP2A) in the secretory process. In unstimulated RBL-2H3 cells, okadaic acid pretreatment inhibited PP2A activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81d20629711de67cf7f597b63af4e05
https://doi.org/10.1074/jbc.275.9.6144
https://doi.org/10.1074/jbc.275.9.6144
Publikováno v:
Diabetes. 48:2383-2389
Although cytoskeletal proteins such as myosin II are implicated in the control of insulin secretion, their precise role is poorly understood. In other secretory cells, myosin II is predominantly regulated via the phosphorylation of the regulatory lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52e26c5b0004bfca9f193ee784435b7
https://doi.org/10.2337/diabetes.48.12.2383
https://doi.org/10.2337/diabetes.48.12.2383
Publikováno v:
Cell Biology International. 22:855-865
The role of serine/threonine protein phosphatases PP1 and PP2A in mast cell secretion was investigated using the phosphatase inhibitors okadaic acid and calyculin A. Calyculin A (5–25 n m ) inhibited antigen-induced secretion from a rat mucosal mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba7da2daf674eb9f7d2bdeb5cc8970f
https://doi.org/10.1006/cbir.1998.0332
https://doi.org/10.1006/cbir.1998.0332
Publikováno v:
Journal of Biological Chemistry. 273:22729-22737
Activation of protein kinases plays an important role in the Ca2+-dependent stimulation of insulin secretion by nutrients. The aim of the present study was to identify kinase substrates with the potential to regulate secretion because these have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3189b25063cd55a307d76ae717e5d78
https://doi.org/10.1074/jbc.273.35.22729
https://doi.org/10.1074/jbc.273.35.22729